Qhov sib txawv tseem ceeb ntawm Hexokinase thiab Glucokinase yog tias Hexokinase muaj nyob rau hauv tag nrho cov ntaub so ntswg uas tsis yog daim siab thiab beta hlwb ntawm pancreas thaum Glucokinase tsuas muaj nyob rau hauv daim siab thiab beta hlwb ntawm pancreas.
Hexokinase thiab Glucokinase yog ob isozymes uas ua rau cov tshuaj tiv thaiv tib yam ntawm ob qhov chaw sib txawv. Lawv hloov cov piam thaj mus rau hauv qabzib 6-phosphate, uas yog thawj cov tshuaj tiv thaiv ntawm glycolysis. Yog li ntawd, los ntawm kev siv ATP, lawv ntxiv ib pab pawg phosphate rau cov piam thaj thiab hloov cov qauv. Txawm li cas los xij, ob lub enzymes no muaj qhov sib xws nrog rau qhov sib txawv, uas peb yuav tham txog ntawm no.
Hexokinase yog dab tsi?
Hexokinase yog cov enzyme uas catalyzes hloov cov piam thaj rau hauv qabzib 6-phosphate hauv feem ntau ntawm cov ntaub so ntswg. Yog li ntawd, cov enzyme no muaj ntau nyob rau hauv txhua hom ntaub so ntswg uas tsis yog daim siab thiab beta hlwb ntawm cov txiav. Nws siv hexoses xws li qabzib, fructose, galactose, thiab lwm yam raws li nws cov substrate thiab ntxiv ib pab pawg phosphate thiab hloov cov qauv. Rau qhov kev hloov pauv no, nws siv ATP (lub zog). Nws muaj kev sib raug zoo dua rau cov substrate thiab muaj qhov qis Km thiab qis Vmax tus nqi.
Daim duab 01: Hexokinase
Cov khoom lag luam concentration inhibits hexokinase. Tsis tas li ntawd, nws tsis cuam tshuam los ntawm cov tshuaj hormones. Txawm tias nyob rau hauv qis concentration ntawm qabzib, hexokinase tuaj yeem ua rau lawv.
Glucokinase yog dab tsi?
Glucokinase yog ib qho isozyme ntawm hexokinase, uas yog ib qho enzyme tshwj xeeb uas muaj nyob hauv daim siab thiab beta hlwb ntawm cov txiav. Yog li ntawd, nws ua haujlwm nyob rau hauv siab concentration ntawm qabzib. Ntxiv mus, nws cov Km thiab Vmax yog siab, thiab yog li ntawd, nws muaj kev sib raug zoo ntawm cov piam thaj.
Daim duab 02: Glucokinase
Glucokinase kuj yog catalyzed los ntawm thawj kauj ruam ntawm glycolysis, uas hloov cov piam thaj rau hauv qabzib 6-phosphate. Zoo ib yam li hexokinase, glucokinase kuj siv ATP rau qhov kev hloov pauv no. Cov tshuaj hormone insulin tswj kev ua haujlwm ntawm glucokinase. Txawm li cas los xij, tsis zoo li hexokinase, glucokinase tsis tuaj yeem tswj tau los ntawm kev tawm tswv yim inhibition.
Dab tsi zoo sib xws ntawm Hexokinase thiab Glucokinase?
- Ob leeg Hexokinase thiab Glucokinase siv ATP thaum lub sij hawm catalysis.
- Lawv ntxias cov kev hloov pauv.
- Ob leeg hnov qab nrog qabzib.
- ob leeg yog isozymes
- Lawv hloov cov piam thaj rau hauv qabzib 6-phosphate.
Qhov txawv ntawm Hexokinase thiab Glucokinase yog dab tsi?
Hexokinase thiab glucokinase yog isozymes uas ua rau tib cov tshuaj tiv thaiv. Txawm li cas los xij, hexokinase muaj ntau hauv txhua hom ntaub so ntswg uas tsis yog daim siab thiab beta hlwb ntawm pancreas thaum glucokinase muaj nyob hauv daim siab thiab beta hlwb ntawm pancreas. Qhov no yog qhov sib txawv tseem ceeb ntawm hexokinase thiab glucokinase. Ntxiv mus, hexokinase muaj tsawg Km thiab Vmax qhov tseem ceeb piv rau glucokinase. Txawm li cas los xij, nws txoj kev sib raug zoo ntawm cov piam thaj yog qhov sib piv rau glucokinase. Tsis tas li ntawd, hexokinase ua haujlwm ntawm qhov qis qis ntawm cov piam thaj. Tab sis glucokinase tsuas yog ua haujlwm ntawm qhov siab ntawm cov piam thaj. Cov ntaub ntawv hauv qab no nthuav tawm cov ntsiab lus ntxiv ntawm qhov sib txawv ntawm hexokinase thiab glucokinase.
Summary – Hexokinase vs Glucokinase
Ob leeg hexokinase thiab glucokinase catalyze tib cov tshuaj tiv thaiv ntawm glycolysis. Hexokinase muaj nyob rau hauv yuav luag tag nrho cov ntaub so ntswg thaum glucokinase muaj nyob rau hauv daim siab thiab beta hlwb ntawm lub txiav. Lawv siv ATP los hloov cov piam thaj rau hauv qabzib 6-phosphate. Cov Km thiab Vmax qhov tseem ceeb yog qis hauv hexokinase thaum lawv siab hauv glucokinase. Glucokinase ua haujlwm ntawm cov piam thaj ntau dua. Ntawm qhov tod tes, hexokinase tuaj yeem ua haujlwm txawm tias muaj cov piam thaj tsawg. Qhov no yog qhov txawv ntawm hexokinase thiab glucokinase.
