Qhov Tseem Ceeb - Lipolysis vs Lipogenesis
Kev sib xyaw ntawm triglycerides thiab fatty acids los ntawm acetyl coenzyme A yog hu ua lipogenesis. Lipolysis yog cov txheej txheem tawg ntawm triglycerides los tsim fatty acids. Qhov sib txawv tseem ceeb ntawm Lipolysis thiab Lipogenesis yog txheej txheem. Lipolysis yog hydrolysis ntawm cov rog thiab lwm yam lipid molecules rau hauv fatty acids whereas Lipogenesis yog cov synthesis ntawm fatty acids thiab triglyceride los ntawm acetyl coenzyme A thiab lwm yam substrates.
Cov rog yog lub zog ntau dua khaws cov molecules thiab muaj ob zaug li lub zog khaws cia hauv carbohydrates. Dhau li ntawm lub zog cia, cov rog muab ntau yam kev ua haujlwm hauv lub cev nrog rau cov qauv tsim, ua cov tshuaj ua ntej, muab kev tiv thaiv thiab kev ua haujlwm, thiab lwm yam. Cov rog yog tsim los ntawm peb cov fatty acid molecules txuas rau glycerol molecule. Yog li ntawd, rog kuj tseem hu ua triglyceride. Triglycerides khaws cia hauv cov ntaub so ntswg adipose.
YLipolysis yog dab tsi?
Cov concentration ntawm fatty acid nyob rau hauv cov hlwb yog tswj tau zoo txij li thaum unbalanced fatty acid concentration tuaj yeem ua rau ntau yam kab mob xws li ntshav qab zib hom 2, thiab lwm yam. Lipolysis yog ib qho ntawm cov txheej txheem cellular uas zom cov rog (triglycerides) rau hauv cov roj fatty acids dawb. thiab glycerol molecules. Lipolysis yog tsav los ntawm lipase enzymes. Nws yog txheej txheem hydrolysis. Peb ester kev sib txuas ntawm peb fatty acid molecules nrog glycerol molecule yuav tawg thaum lub sij hawm lipolysis los ntawm kev tso tawm dawb fatty acid molecules thiab glycerol molecule.
Ua tiav hydrolysis ntawm triglyceride molecule yog ua los ntawm peb lipases uas yog, adipose triglyceride lipase, hormone-sensitive lipase, thiab monoacylglycerol lipase. Triglyceride molecule yog hydrolyzed rau hauv diacylglycerol los ntawm adipose triglyceride lipase tso ib qho tsis-esterified fatty acid molecule. Diacylglycerol yog hydrolyzed rau hauv monoacylglycerol los ntawm cov tshuaj hormone-rhiab heev lipase tso tawm lwm yam tsis-esterified fatty acid molecule. Monoacylglycerol yog hydrolyzed rau hauv glycerol thiab non-esterified fatty acid los ntawm monoacylglycerol lipase los ntawm tag nrho hydrolyzing triglyceride molecule.
Daim duab 01: Lipolysis
Cov roj ntsha uas tsim tawm dawb thiab glycerol molecules raug tso tawm rau hauv cov ntshav. Lipolysis yog txhawb los ntawm kev hloov pauv hormonal uas tshwm sim hauv lub cev. Kev txo qis ntawm plasma insulin thiab piam thaj ua rau lipolysis. Thiab tseem muaj qib siab ntawm catecholamines, kev loj hlob hormone thiab glucocorticoids nyiam lipolysis.
Lipogenesis yog dab tsi?
Lipogenesis yog cov txheej txheem ntawm kev sib txuas cov roj fatty acids thiab triglycerides los ntawm precursor molecules xws li amino acids, qab zib, PGAL, thiab lwm yam. Lipogenesis tshwm sim hauv cov ntaub so ntswg adipose thiab hauv siab. Lipogenesis yog tswj los ntawm ntau yam xws li cov tshuaj hormones. Polyunsaturated fatty acids, kev loj hlob hormone, leptin, thiab yoo mov inhibit cov rog synthesis. Nws txhawb nqa los ntawm kev noj zaub mov nplua nuj carbohydrate thiab insulin.
Daim duab 02: Cov qauv ntawm Lipid Molecule
Lipogenesis pib nrog tsim cov diacylglycerol los ntawm fatty acid acyl-coenzyme A. Tom qab ntawd cov txheej txheem txuas ntxiv los ntawm kev ntxiv ob lub fatty acid molecules los tsim triglyceride molecule. Glycerol phosphate pathway, monoacylglycerol txoj kev, thiab glyceroneogenesis yog peb txoj hauv kev uas tsim cov diacylglycerol rau lipogenesis. Lub synthesis ntawm triglyceride molecule los ntawm diacylglycerol yog catalyzed los ntawm ob enzymes uas yog acyl-CoA diacylglycerol acyltransferase 1 thiab 2.
Dab tsi yog qhov zoo sib xws ntawm Lipolysis thiab lipogenesis?
- Ob leeg lipolysis thiab lipogenesis yog ob txheej txheem uas piav txog lipomobilization hauv lub cev.
- Ob leeg tshwm sim hauv adipocytes.
- Ob leeg cuam tshuam nrog lipotoxicity.
- Ob leeg lipolysis thiab lipogenesis yog hais txog fatty acids.
- Ob txoj kev koom nrog glycerol thiab triglycerides.
- Lipolysis thiab lipogenesis yog nruj tswj cov txheej txheem ntawm tes.
Qhov txawv ntawm lipolysis thiab lipogenesis yog dab tsi?
YLipolysis vs Lipogenesis |
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| Lipolysis yog cov txheej txheem enzymatic los ntawm triacylglycerol, khaws cia hauv cellular lipid droplets, yog hydrolytically cleaved los tsim glycerol thiab dawb fatty acids. | Lipogenesis yog txheej txheem los ntawm glycerol yog esterified nrog dawb fatty acids los tsim triglyceride. |
| Xeem Kawg | |
| Lipolysis tsim cov roj fatty acid dawb thiab glycerol molecules. | Lipogenesis tsim cov roj fatty acids thiab triglycerides. |
| Catabolic lossis Anabolic | |
| Lipolysis yog cov tshuaj tiv thaiv catabolic. | Lipogenesis yog ib qho tshuaj tiv thaiv anabolic. |
| Fat Build-up | |
| Lipolysis txo cov rog tsim. | Lipogenesis tsub kom rog rog. |
| Enzyme koom nrog | |
| Adipose triglyceride lipase, hormone rhiab lipase, thiab monoacylglycerol lipase koom nrog lipolysis. | Acyl-CoA diacylglycerol acyltransferase 1 thiab 2 koom nrog hauv lipogenesis. |
Summary – Lipolysis vs Lipogenesis
Fat build-up nyob ntawm qhov sib npaug ntawm ob txheej txheem xws li lipogenesis (fat synthesis) thiab lipolysis (fat so). Lipolysis tso tawm fatty acid molecules los ntawm triglycerides los ntawm enzymatic hydrolysis. Lipogenesis synthesizes triglycerides thiab fatty acids molecules los ntawm acetyl coenzyme A thiab lwm yam precursors. Ob qho txheej txheem tshwm sim hauv cov ntaub so ntswg adipose thiab hauv siab. Qhov no yog qhov txawv ntawm lipolysis thiab lipogenesis.
