Qhov Tseem Ceeb Qhov txawv - Cyclic AMP vs AMP
Adenosine monophosphate (AMP) yog ib qho nucleotide uas muaj phosphate pawg, ribose qab zib, thiab nucleobase adenine. Cyclic AMP raug suav hais tias yog tus xa xov thib ob uas feem ntau cuam tshuam thaum lub sijhawm ua haujlwm hauv cov xov tooj ntawm tes. Qhov sib txawv tseem ceeb ntawm cyclic AMP thiab AMP yog hais txog cov qauv ntawm ob lub tebchaw; cyclic AMP yog tam sim no nyob rau hauv ib tug cyclic qauv thaum AMP muaj nyob rau hauv ib tug non-cyclic qauv.
Cov txheej txheem ntawm cov cellular metabolic yog tsav los ntawm cov khoom sib txawv uas muaj nyob hauv cov hlwb lawv tus kheej. Lawv tuaj yeem yog qhov chaw ntawm lub zog lossis kev tswj hwm molecules. Tag nrho cov cellular metabolic txoj kev yog tswj ntawm ntau theem. AMP thiab cyclic AMP yog cov tebchaw uas feem ntau koom nrog cov cell metabolism.
Cyclic AMP yog dab tsi?
Cyclic adenosine monophosphate (cAMP) yog tus xa xov thib ob, ib qho derivative ntawm ATP uas yog ib qho tseem ceeb hauv ntau cov txheej txheem lom neeg xws li intracellular signal transduction, thiab lwm yam. Lub luag haujlwm tseem ceeb ntawm cAMP yog kev tswj hwm cov metabolism. Qhov no tuaj yeem piav qhia ntxiv qhov twg cAMP ua lub luag haujlwm tseem ceeb hauv cov ntsiab lus ntawm kev txhawb nqa thiab kev txhawb nqa ntawm cov piam thaj thiab fatty acid reserves.
Nyob rau hauv daim siab, intracellular cAMP qib tau nce vim qhov stimulation ntawm adenyl cyclase los ntawm glucagon thiab. Qhov xwm txheej no, qhov twg cov qib cAMP yog qhov ua tau zoo hauv kev nce qib ntawm cov piam thaj hauv siab. Qhov kev nce ntxiv no tshwm sim raws li peb txoj kev sib txawv; stimulation ntawm phosphorylase activation, inhibition ntawm glycogen synthetase kev ua si thiab stimulation ntawm gluconeogenesis.
Daim duab 01: Cyclic AMP
Qhov cuam tshuam loj ntawm cAMP hauv cov ntaub so ntswg yog lipolysis thiab glycogenolysis hauv cov ntaub so ntswg adipose thiab cov leeg nqaij feem. cAMP kuj tseem muaj peev xwm txhim kho qhov tso tawm ntawm insulin los ntawm beta hlwb ntawm pancreas. Cov tshuaj insulin tso tawm tau txav mus rau hauv daim siab thiab cov ntaub so ntswg adipose qhov chaw uas nws inhibits qhov tsub zuj zuj ntawm qib siab ntawm cAMP. cAMP muaj peev xwm hauv kev kho kom haum xeeb ntawm ntau cov tshuaj hormones uas yog catabolic. Txij li thaum cAMP muaj peev xwm tso tawm cov tshuaj insulin, nws txoj kev koom tes hauv ntshav qab zib yog tam sim no tau tham.
AMP yog dab tsi?
Adenosine monophosphate (AMP) txhais tau tias yog nucleotide uas muaj phosphate pawg, ribose qab zib thiab nucleobase; adenine. AMP yog ib qho ester ntawm phosphoric acid thiab tseem hu ua 5-adenylic acid. Lub luag haujlwm tseem ceeb tshaj plaws uas tau ua los ntawm AMP thaum lub sijhawm feem ntau ntawm cov txheej txheem cellular metabolic yog nws lub peev xwm los hloov pauv mus rau ADP (adenosine diphosphate) thiab / lossis ATP (Adenosine triphosphate). AMP kuj tseem ceeb heev thaum lub sij hawm synthesis ntawm RNA.
Hais txog cov qauv ntawm AMP, nws tsis muaj lub zog siab phophoanhydride daim ntawv cog lus hauv ADP lossis ATP. AMP tuaj yeem raug tsim los siv ntau txoj hauv kev. Nws tuaj yeem tsim los ntawm ADP qhov twg ob lub ADP molecules hloov mus rau ib qho ATP molecule thiab ib qho AMP molecule (2ADP → ATP + AMP). Hauv lwm txoj hauv kev, AMP tuaj yeem raug tsim los siv cov hydrolysis ntawm lub zog siab phosphate daim ntawv cog lus ntawm ADP (ADP + H 2O → AMP + Pi) lossis ATP (ATP + H 2O → AMP + PPi).
Daim duab 02: AMP
AMP kuj muaj peev xwm hloov mus rau ADP lossis ATP. Thaum pib, AMP hloov mus rau ADP thiab ADP hloov pauv ATP nyob rau hauv muaj cov phosphate inorganic. Cov tshuaj tiv thaiv tuaj yeem raug sau tseg raws li hauv qab no.
AMP + ATP → 2 ADP
ADP + Pi → ATP
AMP kuj tuaj yeem hloov mus rau hauv IMP (Inosine monophosphate) nyob rau hauv muaj cov enzyme myoadenylate deaminase. Hauv cov tshuaj tiv thaiv no, ib pawg ammonia raug tso tawm. Nyob rau hauv cov ntsiab lus ntawm txoj kev catabolic, AMP tuaj yeem hloov mus rau hauv uric acid uas tawm ntawm lub cev tsiaj.
Dab tsi yog qhov zoo sib xws ntawm Cyclic AMP thiab AMP?
- Ob leeg muaj adenine puag, pawg phosphate thiab ribose qab zib.
- Ob lub cAMP thiab AMP yog cov txiaj ntsig ntawm ATP.
- CAMP thiab AMP yog nucleotides.
Qhov txawv ntawm Cyclic AMP thiab AMP yog dab tsi?
Cyclic AMP vs AMP |
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| Cyclic adenosine monophosphate (cAMP) txhais tau tias yog tus xa xov thib ob, uas yog tus lej ntawm ATP thiab tseem ceeb hauv ntau cov txheej txheem lom neeg xws li hauv cov teeb liab intracellular transduction. | Adenosine monophosphate (AMP) txhais tau tias yog nucleotide uas muaj phosphate pawg, ribose qab zib thiab nucleobase adenine. |
| qauv | |
| cAMP muaj cov qauv cyclic. | AMP tsis yog-cyclic. |
| Role | |
| cAMP ua haujlwm ua tus xa xov thib ob ntawm cov txheej txheem kev hloov pauv hauv lub cev. | AMP ua haujlwm raws li nucleotide uas muaj peev xwm hloov mus rau hauv lub zog khaws cia molecules; ADP thiab ATP. |
Summary – Cyclic AMP vs AMP
AMP thiab cyclic AMP yog cov tebchaw uas feem ntau cuam tshuam nrog cell metabolism. Cyclic AMP raug suav hais tias yog tus xa xov thib ob uas feem ntau cuam tshuam nrog cov txheej txheem kev hloov pauv ntawm cov xov tooj ntawm tes. cAMP ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa thiab txhawb nqa cov piam thaj thiab fatty acid reserves.cAMP hauv cov ntaub so ntswg ua rau lipolysis thiab glycogenolysis hauv cov ntaub so ntswg adipose thiab cov leeg nqaij feem. Txij li thaum nws cuam tshuam rau kev tso tawm ntawm insulin, tam sim no nws tseem nyob hauv kev tshawb fawb los tshawb xyuas nws qhov txuas rau ntshav qab zib. Adenosine monophosphate (AMP) txhais tau tias yog nucleotide uas muaj phosphate pawg, ribose qab zib thiab nucleobase adenine. Lub luag haujlwm tseem ceeb uas tau ua los ntawm AMP thaum lub sijhawm cellular metabolic txheej txheem yog nws lub peev xwm los hloov pauv mus rau ADP lossis ATP uas nqa cov khoom siv hluav taws xob siab. Qhov no yog qhov txawv ntawm cAMP thiab AMP.
