Qhov Tseem Ceeb Qhov txawv - Myeloproliferative vs Myelodysplastic
Kev tsim cov qe ntshav sib txawv tshwm sim hauv cov pob txha. Stem cells dag nyob rau hauv cov pob txha sib txawv rau hauv ntau hom cell raws li spectrum ntawm cov kab mob ntawm tes. Cov txheej txheem ntawm kev sib txawv no yog tswj hwm feem ntau ntawm cov noob. Yog li, kev hloov pauv ntawm cov noob no tuaj yeem cuam tshuam tag nrho cov txheej txheem, ua rau muaj ntau yam ntawm cov kab mob hematological uas tau muab faib ua ob pawg xws li myeloproliferative thiab myelodysplastic. Hauv cov kab mob myeloproliferative, muaj qhov nce ntawm cov hlwb hauv cov kab mob sib txawv ntawm cov ntshav. Myelodysplastic hais txog qhov tsis muaj peev xwm ntawm cov qia hlwb kom loj hlob mus rau hauv cov qe ntshav liab, cov qe ntshav dawb, thiab platelets. Yog li, qhov sib txawv tseem ceeb ntawm myeloproliferative thiab myelodysplastic yog tias nyob rau hauv cov kab mob myeloproliferative, muaj qhov nce ntawm cov hlwb ib txwm muaj thaum, hauv cov kab mob myelodysplastic, muaj qhov nce ntawm cov hlwb tsis paub tab.
Myeloproliferative yog dab tsi?
Nyob rau hauv cov kab mob myeloproliferative, muaj ntau cov cell hauv cov kab mob sib txawv ntawm cov ntshav. Lub pathognomic feature ntawm myeloproliferative tej yam kev mob yog lub xub ntiag ntawm ib tug mutated thiab constitutively activated tyrosine kinase noob nrog rau ntau yam aberrations nyob rau hauv lub signaling pathways uas ua rau kom loj hlob zoo kev ywj pheej.
Cov kab mob myeloproliferative feem ntau tshwm sim los ntawm cov kab mob myeloid ntau lub zog thiab qee zaus los ntawm cov qia hlwb pluripotent.
Daim duab 01: Nce Reticulin hauv pob txha pob txha hauv Myeloproliferative Disorders
Kev hloov pauv pathological feem ntau pom hauv cov kab mob no suav nrog,
- Kev nce ntxiv ntawm kev tsav tsheb hauv pob txha pob txha
- YExtramedullary hematopoiesis
- Marrow fibrosis nrog rau cov ntshav peripheral cytopenias
- Kev hloov pauv mus rau tus mob leukemia
Ua raws li yog ntau yam ntawm cov kab mob myeloproliferative:
- mob myelogenous leukemia
- YPolycythemia vera
- Qhov tseem ceeb thrombocytopenia
- YPrimary myelofibrosis
- YSystemic mastocytosis
- Chronic eosinophilic leukemia
- Stem cell leukemia
Myelodysplastic yog dab tsi?
Myelodysplastic yog hais txog qhov tsis muaj peev xwm ntawm cov qia hlwb kom loj hlob mus rau hauv cov qe ntshav liab, qe ntshav dawb thiab platelets. Yog li ntawd, hemopoiesis tsis zoo thiab muaj kev pheej hmoo siab dua ntawm kev tsim mob qog noj ntshav myeloid leukemia.
Nyob rau hauv cov mob myelodysplastic no, cov qia hlwb hauv cov pob txha pob txha raug hloov los ntawm ntau hom neoplastic multipotent qia hlwb uas muaj peev xwm nthuav tawm, tab sis tsis muaj txiaj ntsig. Yog li ntawd, cov neeg mob yuav muaj pancytopenia.
Myelodysplastic mob tuaj yeem yog vim qhov tshwm sim xws li raug hluav taws xob genotoxic lossis idiopathic ua rau.
Daim duab 02: Megakaryocytes hauv Myelodysplastic Disorders
Kev hloov pauv hloov pauv hloov pauv
Muaj pob txha pob txha hyperplasia, uas cuam tshuam nrog kev sib txawv ntawm cov granulocytes, megakaryocytes, erythroids, thiab lwm yam. Qee zaum, kev nce hauv myeloblasts kuj tuaj yeem pom.
Tshuaj Kho Mob
- Feem ntau, cov neeg laus dua 70 xyoo raug cuam tshuam los ntawm tus mob no
- Kev kis kab mob rov muaj dua
- tsis piav qhia hemorrhages
- Tsis muaj zog
Cov kab mob Myelodysplatic tau muab faib ua ntau pawg rau lub hom phiaj ntawm kev ntsuas tus kab mob. Cov neeg mob feem ntau tuag nyob rau hauv 9-29 lub hlis txij thaum pib tshwm sim.
Kev kho mob
- Allogeneic hemopoietic qia cell transplantation
- Tshuaj tua kab mob kom tswj tau kab mob
- khoom siv ntshav
Dab tsi yog qhov zoo sib xws ntawm Myeloproliferative thiab Myelodysplastic?
Ob hom kab mob no feem ntau yog los ntawm kev hloov caj ces cuam tshuam rau kev tsim cov hlwb hauv cov pob txha
Qhov txawv ntawm Myeloproliferative thiab Myelodysplastic yog dab tsi?
YMyeloproliferative vs Myelodysplastic |
|
| Nyob rau hauv cov kab mob myeloproliferative, muaj ntau cov cell hauv cov kab mob sib txawv. | Myelodysplastic yog hais txog qhov tsis muaj peev xwm ntawm cov qia hlwb kom loj hlob mus rau cov qe ntshav liab, cov qe ntshav dawb, thiab cov platelets. |
| Pathognomic nta | |
| Tus kab mob tshwm sim ntawm cov kab mob myeloproliferative yog qhov muaj qhov hloov pauv thiab tsim ua haujlwm tyrosine kinase gene nrog rau ntau yam aberrations nyob rau hauv txoj kev taw qhia uas ua rau muaj kev ywj pheej loj hlob. | Nyob rau hauv cov mob myelodysplastic no, cov qia hlwb hauv cov pob txha pob txha raug hloov los ntawm ntau hom neoplastic multipotent qia hlwb uas muaj peev xwm nthuav tawm tab sis ua tsis tau zoo. |
| Kev Hloov Pathological | |
|
Muaj pob txha pob txha hyperplasia, uas cuam tshuam nrog kev sib txawv ntawm cov granulocytes, megakaryocytes, erythroids, thiab lwm yam. Qee zaum, kev nce hauv myeloblasts kuj tuaj yeem pom. |
Summary – Myeloproliferative vs Myelodysplastic
Nyob rau hauv cov kab mob myeloproliferative, muaj ntau cov cell hauv cov kab mob sib txawv ntawm cov ntshav. Myelodysplastic hais txog qhov tsis muaj peev xwm ntawm cov qia hlwb kom loj hlob mus rau hauv cov qe ntshav liab, cov qe ntshav dawb thiab platelets. Hauv cov kab mob myeloproliferative, muaj qhov nce ntawm cov qe ntshav ib txwm muaj thaum nyob hauv cov kab mob myelodysplastic muaj qhov nce ntawm cov hlwb tsis paub tab. Qhov no yog qhov sib txawv loj ntawm myeloproliferative thiab myelodysplastic.
