Qhov Tseem Ceeb - Staph vs MRSA
Microbes ua rau ntau yam kab mob. Staphylococcus yog ib yam kab mob uas ua rau muaj kev sib txawv hauv tib neeg. Nws feem ntau pom muaj nyob rau hauv nasopharynx thiab daim tawv nqaij txog li 50% ntawm cov neeg nyob rau hauv cov pejxeem. Ntawm qhov tod tes, methicillin resistant staphylococcus aureus lossis MRSA yog ib hom kab mob staphylococcus uas tiv taus methicillin. Staph tsis tiv taus methicillin thaum MRSA tiv taus methicillin. Qhov no yog qhov sib txawv tseem ceeb ntawm staph thiab MRSA.
Staphylococcus yog dab tsi?
Staphylococcus feem ntau pom muaj nyob rau hauv nasopharynx thiab daim tawv nqaij txog li 50% ntawm cov neeg hauv cov pejxeem. Muaj 3 hom kab mob tseem ceeb ntawm staphylococcus li Staphylococcus aureus, Staphylococcus epidermidis thiab Staphylococcus saprophyticus. Nws yog ib qho tseem ceeb kom paub tias staphylococcus thiab streptococcus yog ob hom kab mob sib txawv uas tuaj yeem sib txawv ntawm ib leeg los ntawm gram stain, catalase test thiab kab lis kev cai.
Nyob rau hauv Gram stain, staphylococcal colony tsim cov txiv hmab zoo li pawg tuaj yeem pom meej. Txhua hom staphylococcal muaj cov enzyme catalase. Thaum ib lub voj hlau uas muaj gram zoo cocci yog inoculated rau ntawm tus swb nrog hydrogen peroxide, yog tias npuas tshwm, nws qhia tau hais tias hydrogen peroxide tau tawg mus rau hauv cov pa npuas thiab dej los ntawm cov kab mob no.
YStaphylococcus aureus
qeb no muaj microcapsule nyob ib puag ncig nws cov phab ntsa loj peptidoglycan cell, uas nyob ib puag ncig cov cell membrane uas muaj penicillin binding protein. Staphylococcus aureus muaj ntau cov proteins ntawm phab ntsa ntawm tes uas tuaj yeem cuam tshuam kev tiv thaiv kab mob. Protein A muaj qhov chaw uas tuaj yeem khi rau Fc feem ntawm IgG. Qhov no tiv thaiv kab mob los ntawm opsonization thiab phagocytosis. Coagulase enzyme tuaj yeem ua rau fibrin tsim nyob ib ncig ntawm lub cev, tiv thaiv nws los ntawm phagocytosed. Plaub hom hemolysins muaj xws li alpha, beta, gamma thiab delta; Lawv muaj peev xwm rhuav tshem cov qe ntshav liab, neutrophils, macrophages thiab platelets.
Staphylococcus kuj muaj cov tshuaj hu ua leukocidin uas muaj peev xwm ua kom puas cov leukocytes. CA-MRSA tsim cov leukocidin tshwj xeeb hu ua Panton-Vlentine Leukocidin (PVC). Beta lactamases tsim los ntawm cov kab mob no tuaj yeem rhuav tshem penicillin thiab lwm yam tshuaj tua kab mob zoo sib xws.
Daim duab 01: Staphylococcus aureus
Proteins uas degrade cov ntaub so ntswg
- YHyaluronidase
- Staphylokinase
- Lipase
- Protease
Staphylococcus muaj peev xwm ua tau ntau yam kab mob, uas tuaj yeem faib ua 2 pawg, raws li cov kab mob tshwm sim los ntawm exotoxins thiab cov kab mob tshwm sim los ntawm cov kab mob ncaj qha cuam tshuam los ntawm cov kab mob.
Kab mob tshwm sim los ntawm kev tso tawm exotoxin;
- Gastroenteritis (zaub mov lom)
- Txoj Kev Ua Phem Txhaum Cai
- Scaled Skin Syndrome
Kab mob tshwm sim los ntawm kev cuam tshuam ntawm lub cev;
- Pneumonia
- Meningitis
- Osteomyelitis
- Tus kab mob kis kab mob endocarditis
- Septic mob caj dab
- kab mob tawv nqaij
- YBacteremia/sepsis
- Us tshuaj kis kab mob
Staphylococcus epidermidis
Cov kab mob no yog cov tswv cuab ntawm cov kab mob ib txwm muaj. Staphylococcus epidermidis yog catalase zoo thiab coagulase tsis zoo. Cov kab mob no ua rau cov kab mob nosocomial, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas nyob rau ntawm Foley tso zis catheters los yog intravenous kab thiab yog ib tug nquag daim tawv nqaij kab mob ntawm cov ntshav kab lis kev cai. Staphylococcus epidermidis ua rau muaj kab mob ntawm cov khoom siv hauv lub cev, xws li cov pob qij txha pob txha, pob qij txha pob txha thiab cov hlab ntsha peritoneal dialysis catheters. Qhov no yog tshwm sim los ntawm polysaccharide capsule uas tso cai rau kev ua raws li cov khoom siv no. Kev tawm tsam ntawm cov kab mob no tuaj yeem kho nrog Vancomycin.
MRSA yog dab tsi
Vim tias feem ntau staphylococci secrete penicillinase, lawv yog penicillin resistant. Methicillin, Nafcillin thiab lwm yam penicillinase-resistant penicillins tsis tawg los ntawm penicillinase. Yog li, cov tshuaj no yog siv los tua cov kab mob Staphylococcus aureus. MRSA yog ib pab pawg ntawm Staphylococcus aureus uas tau txais ntau cov tshuaj tiv thaiv methicillin thiab nafcillin uas tau kho los ntawm cov chromosomal DNA ntu (mecA). Qhov no chromosome encodes ib tug tshiab penicillin binding protein 2A uas tuaj yeem ua haujlwm ntawm peptidoglycan cell phab ntsa sib dhos. Txog thaum tsis ntev los no, nyob rau hauv kev cuam tshuam ntawm cov tshuaj tua kab mob hnyav, feem ntau cov kab mob MRSA tau tsim nyob rau hauv qhov chaw noscomial. Cov kab mob no tau muab faib ua kev kho mob lossis tsev kho mob tau txais MRSA lossis HA-MRSA. HA-MRSA feem ntau qhia cov tshuaj tiv thaiv kab mob dav dav. Hauv cov xwm txheej no, Vancomycin dhau los ua ib qho tshuaj tua kab mob zoo tshaj plaws. Tab sis tam sim no, hom Staphylococcus aureus resistant rau Vancomycin kuj tau txheeb xyuas.
Daim duab 02: Kev tshuaj ntsuam electron micrograph ntawm tib neeg neutrophil ingesting MRSA
Zej Zog Tau Txais MRSA
Kev tshwm sim ntawm ntau lub clones ntawm MRSA sab nraum lub tsev kho mob tau teeb tsa tau ua rau cov zej zog tau txais MRSA. Kev tshaj tawm tshaj tawm ntawm cov kab mob CA-MRSA tau pom ntawm cov pab pawg kis las. Tib neeg yog cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos uas tshwm sim los ntawm cov kab mob no. CA-MRSA tsim cov tshuaj lom hu ua Panton Valentine Leukocidin toxin uas cuam tshuam nrog kev tsim ntawm daim tawv nqaij abscesses. Cov noob encoding methicillin tsis kam yog nqa ntawm ib qho genomic strand hu ua SCCmec. CA-MRSA muaj ib qho me me SCCmec hloov tau yooj yim uas kis tau yooj yim ntawm cov kab mob staph. Yog li ntawd, CA-MRSA yog qhov ua tau zoo dua ntawm kev sib kis thiab tam sim no nws yog cov kab mob methicillin resistant staphylococcus feem ntau kis tau ob qho tib si hauv thiab tawm hauv tsev kho mob. Hmoov zoo, CA-MRSA tuaj yeem kho nrog tshuaj tua kab mob hauv qhov ncauj xws li clindamycin thiab trimethoprim-sulfamethoxazole.
Qhov Zoo sib xws ntawm Staph thiab MRSA yog dab tsi?
Ob leeg Staph thiab MRSA yog cov kab mob uas ua rau tib neeg muaj kab mob sib txawv.
Qhov txawv ntawm Staph thiab MRSA yog dab tsi?
Staph vs MRSA |
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| Staphylococcus yog ib yam kab mob uas feem ntau pom raws li ib feem ntawm cov nroj tsuag ib txwm nyob ntawm daim tawv nqaij thiab hauv nasopharynx. | MRSA yog ib hom staphylococcus uas tiv taus Methicillin. |
| Methicillin | |
| Tsis tiv taus methicillin. | Resistant rau methicillin. |
Summary – Staph vs MRSA
Staphylococcus yog ib qho kev pom zoo uas feem ntau pom muaj nyob rau hauv nasopharynx thiab ntawm daim tawv nqaij ntawm tib neeg whereas MRSA yog ib hom kab mob staphylococcus uas tiv taus methicillin. Kev siv tshuaj tua kab mob tsis sib haum xeeb yog qhov laj thawj tseem ceeb ntawm qhov tshwm sim ntawm cov kab mob no tiv thaiv kab mob.
Download PDF Version of Staph vs MRSA
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li cov ntawv sau tseg. Thov download PDF version ntawm no Qhov txawv Ntawm Staph thiab MRSA
