Qhov Tseem Ceeb Qhov txawv - Leydig Cells vs Sertoli Cells
Nyob rau hauv cov ntsiab lus ntawm txiv neej gametogenesis, Leydig hlwb thiab Sertoli hlwb ua lub luag haujlwm tseem ceeb. Lawv pab kev ua haujlwm ntawm cov txiv neej kev ua me nyuam thiab yog li pab tsim cov txiv neej gametes, cov phev, los ntawm cov txheej txheem spermatogenesis. Leydig hlwb muaj nyob nruab nrab ntawm cov tubules seminiferous thaum lub Sertoli hlwb muaj nyob nruab nrab ntawm cov kab mob epithelium ntawm seminiferous tubules. Cov hlwb Leydig yog puag ncig hauv cov duab thiab tam sim no raws li cov pab pawg me me nyob rau hauv ib qho kev ncua deb ntawm ib leeg, Sertoli hlwb yog siab thiab elongated thiab tam sim no raws li ib lub hlwb uas yog nruj nreem packed. Qhov no yog qhov txawv ntawm Leydig hlwb thiab Sertoli hlwb.
Leydig Cells yog dab tsi?
Leydig hlwb tuaj yeem pom ntawm ib sab ntawm cov tubules seminiferous hauv cov noob qes. Lawv tuaj yeem raug hu ua interstitial hlwb ntawm Leydig. Lub luag haujlwm ntawm cov hlwb no yog tsim cov tshuaj hormone testosterone nrog kev pab ntawm luteinizing hormone. Lawv coj cov duab ntawm ib tug polyhedral thiab ib tug loj nucleus yog tam sim no eccentrically. Kwv yees li ntawm ib mus rau peb lub nucleoli thiab ntau heterochromatin uas yog stained nyob rau hauv ib tug maub xim muaj nyob rau hauv lub nucleus.
Lub cytoplasm ntawm Leydig hlwb muaj ntau yam endoplasmic reticula, membrane-bound lipid droplets, thiab ob peb mitochondria. Ntxiv rau cov no, cov xim hu ua lipofuscin, thiab cov qauv siv lead ua zoo li hu ua Reinke crystals kuj muaj nyob hauv cov hlwb. Mature Leydig hlwb txawv nyob rau hauv testis thaum lub sij hawm tom qab yug me nyuam thiab nyob twj ywm tsis ua hauj lwm mus txog rau thaum ib tug hluas nkauj. Nyob rau hauv fetal Leydig hlwb, ib tug txaus tus nqi ntawm testosterone yog tsim nyob rau hauv ib tug txiv neej fetus ntawm gestation lub sij hawm ntawm yim mus rau nees nkaum lub lis piam. Ib chav kawm ntawm cov tshuaj hormones hu ua androgens raug tso tawm los ntawm Leydig hlwb. Nrog rau kev txhawb nqa ntawm pituitary hormone lub luteinizing hormone, cov androgens secrete ob peb cov tshuaj hormones xws li testosterone, dehydroepiandrosterone (DHEA) thiab androstenedione. Ntawm no, cov testosterone yog synthesized thiab tso tawm los ntawm Leydig hlwb vim hais tias cov cholesterol demolishes kev ua si yog nce los ntawm Luteinizing hormone.
Fig 01: Leydig cells
Muaj qee yam kab mob uas tshwm sim hauv Leydig hlwb. Leydig cell hlav thiab adrenomyeloneuropathy yog ob peb yam piv txwv. Leydig cell hlav yog tsim vim Leydig hlwb tau loj hlob txawv txav thiab tswj tsis tau. Cov no yog active hormonally li, tsim ntau tshaj testosterone. Adrenomyeloneuropathy yog kab mob tshwm sim los ntawm cov kab mob Leydig cuam tshuam. Ntawm no, theem ntawm testosterone yog txo qis dua li ib txwm muaj vim tias qib siab dua ntawm Luteinizing hormone thiab Follicle stimulating hormone. Tsis tas li ntawd, ntxiv rau, kev puas tsuaj ntawm Leydig hlwb kuj yog tshwm sim los ntawm kev kho hluav taws xob sab nrauv stimulation.
Sertoli Cells yog dab tsi?
Spermatogenesis yog ib txoj kev uas cov phev, txiv neej gametes, yog tsim nyob rau hauv lub testis. Nws tshwm sim nyob rau hauv lub seminiferous tubules ntawm lub testis. Cov tubules seminiferous yog cov txheej txheem nyuaj uas yog lined los ntawm stratified epithelium nrog lub xub ntiag ntawm ob hom cell; spermatogenic hlwb thiab Sertoli hlwb. Spermatogenic hlwb ua rau spermatozoa nce mus txog ntau theem kev loj hlob thaum Sertoli hlwb koom nrog muab cov as-ham thiab txhawb nqa rau cov tubules seminiferous.
Sertoli hlwb yog muab los ntawm cov kab mob epithelial ntawm cov gonads tsim. Lawv yog cov avascular hlwb. Cov hlwb no siab thiab columnar nyob rau hauv cov qauv thiab yog tam sim no nyob rau hauv los ntawm hauv qab daus daim nyias nyias mus rau lub lumen. Lawv koom nrog hauv kev tsim cov hnab ris nyob ib ncig ntawm kev sib txawv thiab nthuav cov kab mob. Sertoli hlwb muab cov as-ham rau cov hlwb thiab koom nrog hauv phagocytic kev txiav txim kom tshem tawm ntau tshaj cytoplasm ntawm cov spermatids uas tsis tsim nyog rau kev tsim cov phev. Tight junctions txuas Sertoli hlwb ua ke uas kaw lub tubule rau hauv ob lub compartments; lub basal compartment, uas yog ze rau lub basal lamina thiab adluminal compartment, uas yog ze rau lub lumen. Qhov no ua rau cov ntshav-testis barrier uas tiv thaiv kev dhau ntawm cov molecules loj ntawm ob lub compartments.
Fig 02: Sertoli cell nodule
Qhov teeb meem no tsim los ntawm Sertoli hlwb koom nrog kev sib txawv ntawm cov cell sib txawv ntawm cov spermatogenesis los ntawm cov ntshav uas suav nrog kev tsim cov spermatogonia, spermatocytes, spermatids thiab cov phev laus. Sertoli cells koom nrog hauv kev tsim cov kua dej hauv lub cev. Qhov no yog qhov tseem ceeb hauv txoj kev loj hlob ntawm cov spermatozoa vim cov kua dej muaj protein ntau; ABP (androgen binding protein) uas khi thiab concentrates testosterone. Nws kuj muaj cov haujlwm ntawm kev zais cov tshuaj hormones, inhibin, uas inhibits kev tso tawm ntawm FSH thiab tswj tus nqi ntawm spermatogenesis.
Dab tsi yog qhov zoo sib xws ntawm Leydig Cells thiab Sertoli Cells?
Ob hom hlwb pab ua haujlwm ntawm cov tubules seminiferous thiab cov txheej txheem spermatogenesis
Qhov txawv ntawm Leydig Cells thiab Sertoli Cells yog dab tsi?
Leydig Cells vs Sertoli Cells |
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| Leydig hlwb yog cov hlwb uas tsim cov testosterone nyob rau hauv lub xub ntiag ntawm luteinizing hormone (LH) | Sertoli hlwb yog cov hlwb somatic ntawm lub testis uas yog qhov tseem ceeb rau kev tsim cov qe ntshav thiab spermatogenesis |
| Tam sim no nruab nrab ntawm cov tubules seminiferous. | Tam sim no nruab nrab ntawm cov kab mob epithelium ntawm cov tubules seminiferous. |
| hom hlwb | |
| Cov hlwb yog puag ncig thiab pom hauv cov pab pawg me. | Cells siab thiab elongated thiab tshwm sim raws li ib lub hlwb nruj nreem ntim. |
| Function | |
| Kev koom tes hauv kev tsim cov testosterone. | Muab kev txhawb nqa thiab cov khoom noj rau cov tubules seminiferous thiab tsim cov kua hauv lub cev nrog ABP. |
Summary – Leydig Cells vs Sertoli Cells
Leydig hlwb thiab Sertoli hlwb yog ob yam tseem ceeb ntawm tes tam sim no nyob rau hauv cov tubules seminiferous ntawm testis ntawm txiv neej kev ua me nyuam. Ob lub hlwb nquag koom nrog hauv cov txheej txheem spermatogenesis. Leydig hlwb muaj nyob nruab nrab ntawm cov tubules seminiferous. Lub luag haujlwm ntawm cov hlwb no yog tsim cov tshuaj hormone testosterone nrog kev pab ntawm luteinizing hormone. Lawv yog puag ncig hauv cov duab thiab tshwm sim ua pawg. Leydig cell hlav yog tsim vim Leydig hlwb tau loj hlob txawv txav thiab tswj tsis tau. Sertoli hlwb yog siab, elongated hlwb uas tshwm sim raws li ib lub hlwb thiab koom nyob rau hauv kev txhawb nqa thiab muab cov as-ham txaus rau cov tubules seminiferous rau nws txoj haujlwm zoo. Lawv pom nyob rau hauv-nruab nrab ntawm cov kab mob epithelium ntawm seminiferous tubules. Qhov no tuaj yeem piav qhia raws li qhov sib txawv ntawm Leydig hlwb thiab Sertoli hlwb.
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Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Leydig Cells thiab Sertoli Cells
