Qhov Tseem Ceeb - T Cell Dependent vs Independent Antigens
Nyob rau hauv cov ntsiab lus ntawm kev tiv thaiv kab mob, antigens yog cov molecules tshwj xeeb uas muaj peev xwm ua rau muaj kev tiv thaiv kab mob tshwj xeeb uas tsim cov tshuaj tiv thaiv raws li. Antibodies yog tshwj xeeb rau cov antigens. Antigen nthuav tawm cov hlwb yog ib hom khoom siv hlwb uas tsim cov complexes nrog Major Histocompatibility Complexes (MHC) los qhia cov antigens. T cell lymphocytes yog cov hlwb tshwj xeeb lossis cov qe ntshav dawb uas paub txog antigens xaiv. Nyob ntawm T cell lymphocytes, antigens yog ob hom; T cell-dependent antigens thiab T cell ywj siab antigens. T cell-dependent antigens tsis tuaj yeem txhawb kev ua haujlwm ncaj qha ntawm B hlwb hauv kev tsim cov tshuaj tiv thaiv kab mob yam tsis muaj kev pab los ntawm T cell thaum T cell ywj pheej antigens muaj peev xwm ua kom ncaj qha stimulation ntawm B hlwb hauv kev tsim cov tshuaj tiv thaiv yam tsis muaj kev pab ntawm T cell.. Qhov no yog qhov sib txawv tseem ceeb ntawm T cell-dependent thiab ywj siab lymphocytes.
T Cell Dependent Antigens yog dab tsi?
T cell-dependent antigens yog cov antigens uas tsis muaj peev xwm ntawm kev txhawb nqa ncaj qha ntawm B hlwb hauv kev tsim cov tshuaj tiv thaiv tsis muaj kev pab ntawm T hlwb. Qhov no pab tsim cov cytokines. Cytokines tuaj yeem yog interferons, interleukins lossis loj hlob yam. Cytokines koom nrog hauv kev ua kom, sib txawv, thiab kev loj hlob ntawm B hlwb.
Daim duab 01: T Cell Dependent B Cell ua kom
T cell-dependent antigens yog cov proteins. Ntau cov tshuaj tiv thaiv antigen muaj nyob hauv T cell-dependent antigens.
T Cell Independent Antigens yog dab tsi?
T cell-independent antigens yog ib hom antigens uas muaj peev xwm induce ncaj qha stimulation ntawm B hlwb nyob rau hauv zus tau tej cov tshuaj tiv thaiv yam tsis muaj kev pab los ntawm T cell. T cell-independent antigens yog polymeric antigens xws li polysaccharides. Cov lus teb raug ntxias rau T cell ywj pheej antigens txawv ntawm cov lus teb uas raug ntxias mus rau ib qho antigen. Lawv muaj tib qhov kev txiav txim siab antigenic nrog ntau qhov kev rov ua dua, thiab qhov no yog ib yam ntxwv ntawm T cell ywj siab antigens.
Ntau hom antigens no muaj peev xwm ua kom B cell clones uas tshwj xeeb rau cov antigens. Cov txheej txheem no hu ua polyclonal activation. Cov antigens no tau muab faib ua ob pawg; Hom I thiab Hom II. Lub subdivision tshwm sim raws li lub peev xwm ntawm Hom I thiab Hom II hlwb rau polyclonally qhib B hlwb. Hom I T cell ywj pheej antigens raug suav tias yog polyclonal activators thaum Hom II T cell ywj pheej antigens tsis yog cov activators. Hom I antigens muaj qhov tseem ceeb B cell activating kev ua si uas induces ncaj qha proliferation thiab sib txawv ntawm B lymphocytes uas tshwm sim tsis muaj stimulation ntawm B hlwb. Cov antigens ua haujlwm ntawm nws tus kheej ntawm lawv qhov tshwj xeeb BCR. Kev ua kom B hlwb tshwm sim los ntawm kev hu xov tooj zoo li receptors uas muaj nyob rau saum npoo ntawm B hlwb thaum BCR stimulation tiav.
Daim duab 02: Kev ua kom ncaj qha ntawm B Cells los ntawm antigens
Hom II antigens muaj cov qauv rov ua dua hu ua epitopes. Cov hlwb no tsis muaj kev ua haujlwm ntawm B cell activation. Hom II antigens qhib tsuas yog B hlwb paub tab. Lawv ua kom lub cev tsis muaj zog B hlwb uas tiv thaiv kev koom tes ntawm B hlwb tsis paub qab hau hauv txhua qhov lus teb ntawm lub cev tsis muaj zog. Cov antigens no raug suav hais tias yog kev tiv thaiv rau kev degradation thiab yog li ntawd yuav pheej mus ntev rau lub sij hawm ntev ntawm lub sij hawm ua cov haujlwm tshwj xeeb ntawm lub cev tiv thaiv kab mob.
Dab tsi yog qhov zoo sib xws ntawm T Cell Dependent thiab Independent Antigens?
Ob hom antigens koom nrog hauv kev tiv thaiv kab mob sib txawv uas ua rau tsim cov tshuaj tiv thaiv los ntawm kev ua kom B hlwb
Qhov txawv ntawm T Cell Dependent thiab Independent Antigens yog dab tsi?
T Cell Dependent Antigen vs T Cell Independent Antigen |
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| T cell-dependent antigens yog cov antigens uas tsis tuaj yeem txhawb kev ua haujlwm ncaj qha ntawm B hlwb hauv kev tsim cov tshuaj tiv thaiv tsis muaj kev pab ntawm T cells. | T cell-independent antigens yog cov antigens uas muaj peev xwm induce ncaj qha stimulation ntawm B hlwb nyob rau hauv zus tau tej cov tshuaj tiv thaiv tsis muaj kev pab los ntawm T cells. |
| tshuaj ntsuab | |
| T cell dependent antigens yog cov proteins. | T cell-independent antigens yog polysaccharides; polymeric antigens uas kuj tuaj yeem yog glycolipids lossis nucleic acids. |
| Secondary Isotypes | |
| IgG, IgE, thiab IgA yog cov isotypes thib ob ntawm T cell nyob | IgG thiab IgA yog cov isotypes thib ob ntawm T cell ywj pheej antigens. |
Summary – T Cell Dependent vs Independent Antigens
Antigens yog cov molecules tshwj xeeb uas muaj peev xwm ua rau muaj kev tiv thaiv kab mob hauv kev tsim cov tshuaj tiv thaiv raws li. Antigen-presenting cells tso cov antigens los ntawm MHC molecules. Raws li kev sib cuam tshuam ntawm antigens nrog T hlwb, muaj ob hom antigens. Lawv yog T cell-dependent antigens thiab T cell ywj siab antigens. T cell-dependent antigens tsis tuaj yeem txhawb kev ua haujlwm ncaj qha ntawm B hlwb hauv kev tsim cov tshuaj tiv thaiv tsis muaj kev pab ntawm T hlwb. Cov antigens no suav nrog follicular B hlwb, thiab cov lus teb thib ob tuaj yeem raug ntxias vim muaj cov cim xeeb B hlwb. T cell-independent antigens muaj peev xwm induce ncaj qha stimulation ntawm B hlwb nyob rau hauv zus tau tej cov tshuaj tiv thaiv tsis muaj kev pab los ntawm T hlwb. Lawv tuaj yeem muab faib ua ob pawg; hom I thiab hom II. Qhov no yog qhov txawv ntawm T cell dependent thiab T cell ywj siab antigens. Ob hom antigens koom nrog hauv kev tiv thaiv kab mob sib txawv uas ua rau tsim cov tshuaj tiv thaiv kab mob los ntawm kev ua kom B hlwb.
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Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm T Cell Dependent thiab Independent Antigen
