Qhov sib txawv tseem ceeb ntawm TIM thiab TOM complex yog tias TIM (translocase ntawm lub puab daim nyias nyias) complex yog ib tug complex ntawm cov proteins pom nyob rau hauv lub puab mitochondrial membrane ntawm mitochondria thaum TOM (translocase ntawm lub txheej membrane) complex yog ib tug complex. Ntawm cov proteins pom nyob rau hauv lub mitochondrial membrane ntawm lub mitochondria.
TIM thiab TOM complexes yog ob txoj hauv kev ntawm cov proteins nyob rau hauv mitochondrial puab thiab sab hauv daim nyias nyias uas translocate proteins uas tsim los ntawm nuclear DNA los ntawm lub mitochondrial membrane siv nyob rau hauv oxidative phosphorylation. Lawv tseem ceeb heev hauv cellular biochemistry. Ntxiv mus, cov protein complexes no ua haujlwm zoo sib xws rau TIC thiab TOC protein complexes nyob rau hauv lub puab thiab sab hauv daim nyias nyias ntawm chloroplast.
TIM Complex yog dab tsi?
TIM complex yog ib qho nyuaj ntawm cov proteins pom nyob rau hauv lub puab mitochondrial membrane ntawm mitochondria. Cov khoom ntawm TIM complex pab txhawb kev hloov pauv ntawm cov proteins thoob plaws hauv daim nyias nyias thiab mus rau mitochondrial matrix. Lawv kuj ib txwm yuav tsum nyob rau hauv lub puab mitochondrial daim nyias nyias thiaj li pab txhawb kev nkag ntawm cov proteins rau hauv lub puab mitochondrial membrane. Cov complex no feem ntau suav nrog cov tswv cuab ntawm mitochondrial carrier tsev neeg ntawm cov proteins. Ob peb TIM complexes tau raug txheeb xyuas, xws li TIM22 thiab TIM23.
Ntxiv mus, TIM22 yog lub luag haujlwm rau kev kho kom haum rau kev sib koom ua ke ntawm cov cab kuj preprotein rau hauv daim nyias nyias. Tim22 yog ib lub subunit ntawm TIM22 complex, uas tsim ib tug channel nyob rau hauv lub puab membrane. Nws yog hu ua tus cab kuj translocase. Tim54 thiab Tim me me xws li Tim9, Tim10, thiab Tim12 kuj tau pab txhawb rau TIM22 complex. Tim 18 kuj yog nyob rau hauv no complex; Txawm li cas los xij, nws txoj haujlwm tseem tsis tau paub. Tsis tas li ntawd, TIM23 complex pab txhawb kev hloov pauv ntawm matrix tsom cov proteins rau hauv mitochondrial matrix. Cov proteins no muaj cleavable presequence. Cov complex no yog tsim los ntawm subunits xws li Tim 17, Tim 21, thiab Tim 23, uas pab mus rau lub structural tsim ntawm lub translocation channel uas spans lub puab membrane, thaum Tim 44 yog ib tug peripheral membrane protein.
TOM Complex yog dab tsi?
TOM complex yog ib qho nyuaj ntawm cov proteins uas pom nyob rau hauv sab nrauv mitochondrial membrane ntawm mitochondria. Nws tso cai rau kev txav ntawm cov protein los ntawm qhov teeb meem no thiab mus rau hauv qhov chaw nruab nrab ntawm mitochondria. Feem ntau ntawm cov proteins uas xav tau rau kev ua haujlwm mitochondrial yog encoded los ntawm cov nucleus ntawm tes. Lub txheej membrane ntawm mitochondria yog impermeable rau loj molecules. Lub TOM thiab TIM complexes ua ke hloov cov proteins loj hauv mitochondria. Ntxiv mus, ntau cov proteins hauv TOM complex, xws li TOMM22 tau pom thawj zaug hauv cov kab mob xws li Neurospora crassa thiab Saccharomyces cerevisiae.
Tsis tas li ntawd, TOM complex tsim ib qho nyuaj ua los ntawm Tom 70, Tom 22, Tom 20, Tom 40, Tom 7, Tom 6 thiab Tom 5. Tom 22 thiab Tom 20 yog preprotein receptors uas yog lub luag haujlwm rau kev lees paub. ntawm cleavable presequence muaj los ntawm mitochondrial-targeted proteins. Tom 70 kuj yog ib qho preprotein uas yog lub luag haujlwm tseem ceeb rau kev lees paub ntawm cov preproteins uas tsis yog-cleavable thiab ua raws li lub ntsiab lus rau chaperone khi. Tom40 yog lub hauv paus tseem ceeb ntawm lub translocase complex thiab complexes nrog Tom22. Tom40 tsim cov khoom siv hauv nruab nrab cov channel nrog lub cheeb ntawm kwv yees li 2.5nm.
Qhov Zoo sib xws ntawm TIM thiab TOM Complex yog dab tsi?
- TIM thiab TOM complex yog ob txoj hauv kev ntawm cov proteins nyob rau hauv mitochondrial sab hauv thiab sab nrauv.
- Ob txoj hauv kev pab txhawb kev hloov pauv cov proteins uas tsim los ntawm nuclear DNA los ntawm mitochondrial membrane siv rau hauv oxidative phosphorylation.
- Ob txoj kev ua haujlwm zoo sib xws rau TIC thiab TOC cov protein ntau nyob rau sab hauv thiab sab nrauv ntawm chloroplast.
- Cov complexes no pab txhawb kev hloov pauv ntawm impermeable loj protein molecules ntau dua 500 D altons.
- Lawv ua haujlwm ua ke nrog ib leeg txhawm rau hloov cov protein mus rau hauv mitochondrial matrix.
Qhov txawv ntawm TIM thiab TOM Complex yog dab tsi?
TIM complex muaj nyob rau hauv lub puab mitochondrial membrane ntawm lub mitochondria, thaum TOM complex pom nyob rau hauv lub mitochondrial membrane ntawm lub mitochondria. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm TIM thiab TOM complex. Tsis tas li ntawd, TIM complex muaj qhov hnyav molecular ntawm 440 kDa, thaum TOM complex muaj qhov hnyav ntawm 400 txog 600 kDa.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm TIM thiab TOM complex hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – TIM vs TOM Complex
TIM thiab TOM complex yog ob txoj hauv kev ntawm cov proteins uas muaj txiaj ntsig zoo hauv cellular biochemistry. Lawv pab txhawb txoj kev hloov pauv ntawm cov proteins uas tau tsim los ntawm nuclear DNA los ntawm mitochondrial membrane siv rau hauv oxidative phosphorylation. TIM complex muaj nyob rau hauv lub puab mitochondrial membrane ntawm lub mitochondria, thaum TOM complex muaj nyob rau hauv lub sab nrauv mitochondrial membrane ntawm lub mitochondria. Yog li, qhov no qhia txog qhov sib txawv ntawm TIM thiab TOM complex.
