Key Difference – SSRI vs SNRI
Selective Serotonin Reuptake Inhibitors (SSRI) thiab Serotonin Norepinephrine Reuptake Inhibitors (SNRI) yog ob hom tshuaj tiv thaiv kev nyuaj siab uas tau sau tseg ua tshuaj rau kev nyuaj siab. Reuptake inhibitors tiv thaiv kev rov ua dua ntawm cov neurotransmitters los ntawm cov hlwb neuronal tom qab cov paj hlwb xa mus. Neurotransmitters yog secreted los ntawm presynaptic knobs rau hauv lub synapse los pab txhawb lub paj hlwb impulse kis mus rau lub post synaptic pob qhov rooj ntawm cov nyob ib sab neuron. Yog li, thaum lub paj hlwb impulse kis tau tiav, cov neuron yuav coj cov neurotransmitters ntau dhau rov qab mus rau nws lub xov tooj ntawm tes, pib lub paj hlwb tom ntej. Reuptake inhibitors thaiv cov txheej txheem no los ntawm kev thaiv cov receptors uas koom nrog hauv cov txheej txheem rov ua dua, uas ua rau muaj cov neurotransmitters hauv synapse, ua kom muaj txiaj ntsig zoo ntawm cov hlab ntsha impulse kis tau tus mob thiab ua raws li cov tshuaj tiv thaiv. Qhov sib txawv tseem ceeb ntawm SSRIs thiab SNRIs yog nyob ntawm hom neurotransmitters lawv ua. SSRIs inhibit qhov kev rov ua dua ntawm Serotonin thaum SNRIs inhibit qhov rov ua dua ntawm Serotonin thiab Norepinephrine.
SSRIs yog dab tsi?
Serotonin yog ib qho neurotransmitter uas feem ntau pom nyob rau hauv lub plab zom mov. Nws kuj raug suav hais tias yog qhov muaj peev xwm mus ob peb vas stabilizer. Selective Serotonin Reuptake Inhibitors (SSRI) tseem hu ua serotonin-specific reuptake inhibitors, los yog serotonergic antidepressants yog ib hom tshuaj tiv thaiv kev nyuaj siab uas muaj cov haujlwm tshwj xeeb ntawm inhibiting serotonin reuptake los ntawm neurons thiab tiv thaiv cov txheej txheem hloov cov neurotransmitter. Cov inhibitors xaiv txheeb xyuas cov receptors uas koom nrog hauv kev rov ua dua ntawm serotonin thiab thaiv lawv. Qhov no ua rau muaj kev muaj ntau ntxiv ntawm serotonin, thiab serotonin no pab txhawb kev xa paj hlwb kom rov qab tau cov tshuaj sib npaug.
Daim duab 01: Serotonin ua ib qho Neurotransmitter
SSRIs yuav tsum tau tswj hwm raws li tus kws kho mob cov cai, thiab tus neeg tau txais kev hloov pauv zoo tom qab 4 txog 6 lub lis piam ntawm kev kho mob. Kev mob tshwm sim ntawm kev siv ntau dhau ntawm SSRI yog xeev siab, kiv taub hau, tsis xis nyob thiab qaug zog thiab qhov ntau npaum li cas txawv ntawm ib tus neeg mus rau ib tus neeg nyob ntawm seb hom kev nyuaj siab, qhov hnyav, thiab lwm yam kev mob nkeeg yav dhau los. Pom zoo SSRIs suav nrog Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, thiab Sertraline.
SNRIs yog dab tsi?
Serotonin, raws li tau piav qhia saum toj no, yog lub siab stabilizer thaum norepinephrine, uas yog neurotransmitter, yog lub ntsiab neurotransmitter siv los ntawm lub paj hlwb sympathetic. Norepinephrine feem ntau ua rau lub cev muaj zog tshwj xeeb lossis cov leeg nqaij hauv kev teb rau kev txhawb nqa; Qhov no feem ntau yog cov txheej txheem siv hluav taws xob uas ua rau lub plawv dhia ntau ntxiv los yog nce hauv calorie ntau ntau. Serotonin Norepinephrine Reuptake Inhibitors lossis SNRIs thaiv cov receptors rau ob leeg Serotonin thiab Norepinephrine, inhibiting txheej txheem ntawm reuptake ntawm cov neurotransmitters. Yog li, SNRIs feem ntau siv tau zoo hauv kev kho mob ntawm kev nyuaj siab ntev thiab mob ntev.
Daim duab 02: SNRIs
Pom zoo SNRIs suav nrog Duloxetine, Venlafaxine, Desvenlafaxine, thiab Levomilnacipran. Cov kev mob tshwm sim ntawm SNRIs feem ntau yog nyob ntawm daim ntawv SNRI noj, thiab cov tsos mob muaj xws li xeev siab, nkees, thiab kiv taub hau.
Qhov Zoo sib xws ntawm SSRI thiab SNRI yog dab tsi?
- SSRI thiab SNRI yog reuptake inhibitors.
- Txoj kev ua haujlwm ntawm ob qho tshuaj zoo ib yam. Lawv thaiv cov reuptake receptors hauv cov neurons inhibiting reuptake ntawm neurotransmitters.
- Ob hom ua haujlwm tsuas yog ntawm cov tshuaj neurotransmitters.
- Ob yam tshuaj ua raws li tshuaj tiv thaiv kev nyuaj siab.
- Lawv ua rau presynaptic membrane receptors.
- Cov kev mob tshwm sim tuaj yeem ua tau nrog ob yam tshuaj raws li cov txheej txheem kho tsis tau.
Qhov txawv ntawm SSRI thiab SNRI yog dab tsi?
SSRI vs SNRI |
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| SSRI yog ib qho tshuaj tiv thaiv kev ntxhov siab uas thaiv cov receptors rov qab los ntawm Serotonin hauv cov pob qhov rooj presynaptic. | SNRI yog ib qho tshuaj tiv thaiv kev nyuaj siab uas thaiv cov reuptake receptors ntawm ob qho tib si Serotonin thiab Norepinephrine ntawm lub presynaptic membrane. |
| Yam ntawm Neurotransmitter | |
| SSRI tsuas yog ua rau serotonin. | SNRI ua rau ob leeg serotonin thiab norepinephrine. |
| Specificity | |
| SSRIs yog qhov tshwj xeeb heev. | SNRIs tsis yog qhov tshwj xeeb vim tias lawv muaj kev sib raug zoo ntawm Serotonin thiab Norepinephrine |
| Kev xaiv | |
| SSRI tsuas yog xaiv cov receptors lub luag haujlwm rau Serotonin reuptake. | SNRI muaj peev xwm xaiv ob hom receptors rau Serotonin reuptake thiab Norepinephrine reuptake. |
| SSRI yog ib qho tshuaj tiv thaiv kev nyuaj siab. | SNRI yog ib qho tshuaj tiv thaiv kev nyuaj siab tshiab tau tsim. |
Summary – SSRI vs SNRI
SSRIs thiab SNRIs yog cov tshuaj tiv thaiv kev nyuaj siab uas tuaj yeem cuam tshuam cov txheej txheem rov qab los ntawm cov neurotransmitters los ntawm cov receptors hauv pre-synaptic membrane, yog li ua kom muaj cov neurotransmitters rau kev xa paj hlwb zoo. SSRIs tsuas yog thaiv Serotonin receptors thaum SNRIs thaiv ob leeg Serotonin thiab Norepinephrine receptors. Qhov no yog qhov txawv ntawm SSRI thiab SNRI.
Download PDF Version of SSRI vs SNRI
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm SSRI thiab SNRI.
