Qhov Tseem Ceeb - Fibrin vs Fibrinogen
Thaum cov hlab ntsha raug mob lossis raug txiav, cov ntshav poob ntau dhau yuav tsum tiv thaiv ua ntej nws ua rau poob siab lossis tuag. Qhov no yog ua los ntawm kev hloov cov ntsiab lus tshwj xeeb hauv cov ntshav mus rau hauv cov khoom tsis zoo gel zoo li ntawm qhov chaw raug mob. Qhov no yog hu ua ntshav txhaws lossis ntshav coagulation. Ntshav coagulation yog ua tiav los ntawm kev ua cov ntshav txhaws. Cov ntshav txhaws muaj ib lub ntsaws ntawm platelets thiab lub network ntawm insoluble fibrin molecules. Fibrin ua ke nrog cov platelets ua ib lub ntsaws rau ntawm cov hlab ntsha puas tsuaj los tiv thaiv kev poob ntshav ntxiv. Fibrin yog tsim los ntawm fibrinogen. Qhov sib txawv tseem ceeb ntawm fibrin thiab fibrinogen yog tias fibrin yog ib qho tsis muaj ntshav plasma protein thaum fibrinogen yog cov protein ntau hauv cov ntshav plasma.
Fibrin yog dab tsi?
Hemostasis yog txheej txheem ntuj tsim los tiv thaiv los ntshav ntau dhau tom qab raug mob. Nws yog cov txheej txheem ntawm ntuj ntshav txhaws uas ua raws li thawj theem ntawm kev kho qhov txhab. Vasoconstriction, ib ntus nres ntawm kev txiav los ntawm platelet plug thiab ntshav coagulation yog peb kauj ruam hauv hemostasis. Ntshav coagulation feem ntau yog ua los ntawm kev tsim cov fibrin clot. Fibrin yog ib qho insoluble, fibrous thiab non-globular protein uas koom nrog hauv cov ntshav txhaws. Nws yog lub hauv paus ntaub polymer ntawm cov ntshav txhaws. Fibrin tsim tshwm sim nyob rau hauv teb rau kev raug mob nyob rau hauv ib feem ntawm lub vascular system los yog lub circulatory system. Thaum muaj kev raug mob, ib qho protease enzyme hu ua thrombin ua rau fibrinogen thiab ua rau nws polymerize rau hauv fibrin, uas yog ib qho insoluble gel zoo li protein. Tom qab ntawd, fibrin ua ke nrog platelets tsim cov ntshav txhaws ntawm qhov chaw mob kom tsis txhob los ntshav ntxiv.
Kev tsim ntawm fibrin yog tag nrho nyob ntawm thrombin tsim los ntawm prothrombin. Cov fibrinopeptides, uas yog nyob rau hauv nruab nrab cheeb tsam ntawm lub fibrinogen, yog cleaved los ntawm thrombin hloov soluble fibrinogen rau insoluble fibrin polymer. Muaj ob txoj hauv kev uas ua rau kev tsim fibrin. Lawv yog extrinsic pathway thiab intrinsic pathway.
Daim duab 01: Fibrin mesh
Fibrinogen yog dab tsi?
Fibrinogen yog cov kua dej hauv cov ntshav plasma tseem ceeb rau cov ntshav coagulation. Nws yog ib qho loj, complex thiab fibrous glycoprotein nrog peb khub ntawm polypeptide chains koom ua ke los ntawm 29 disulfide daim ntawv cog lus. Thaum muaj kev raug mob hauv cov hlab ntsha, fibrinogen hloov mus rau hauv fibrin uas yog daim ntawv tsis txaus ntawm fibrinogen. Qhov kev hloov pauv no yog catalyzed los ntawm enzyme hu ua thrombin. Thrombin yog tsim los ntawm prothrombin.
Fibrinogen ntau lawm yog txheej txheem tseem ceeb. Nws yog tib txoj kev uas tsim cov fibrin precursor. Kev ua haujlwm tsis zoo lossis kab mob ntawm daim siab tuaj yeem ua rau cov khoom tsis ua haujlwm ntawm fibrin precursors lossis txawv txav fibrinogen nrog txo kev ua haujlwm. Qhov no hu ua dysfibrinogenemia.
Daim duab 02: Fibrinogen
Dab tsi yog qhov zoo sib xws ntawm Fibrin thiab Fibrinogen?
- Fibrin thiab fibrinogen yog cov plasma proteins.
- Ob lub proteins yog tsim los ntawm lub siab.
- Ob leeg cov proteins koom nrog hauv cov ntshav coagulation.
- ob leeg yog cov proteins uas muaj fiber ntau.
Qhov txawv ntawm Fibrin thiab Fibrinogen yog dab tsi?
Fibrin vs Fibrinogen |
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| Fibrin yog ib qho insoluble, dawb, albuminous thiab fibrous protein uas ua lub luag haujlwm tseem ceeb hauv cov ntshav txhaws. | Fibrinogen yog cov plasma protein soluble uas polymerizes rau hauv fibrin los ntawm protease thrombin. |
| Fibrin yog insoluble. | Fibrinogen yog soluble. |
| Fibrin yog tsim los ntawm fibrinogen. | Fibrinogen yog tsim los ntawm peb mRNAs. |
Summary – Fibrin vs Fibrinogen
ntshav txhaws yog txheej txheem tseem ceeb los tiv thaiv los ntshav ntau dhau ntawm qhov raug mob. Fibrin thiab fibrinogen yog ob lub plasma proteins uas koom nrog cov ntshav txhaws. Fibrin yog ib yam kab mob zoo li cov protein uas tsis sib haum xeeb uas yog ib feem tseem ceeb ntawm cov ntshav txhaws. Qhov sib txawv loj ntawm fibrin thiab fibrinogen yog tias fibrin yog ib qho protein uas tsis txaus ntseeg thaum fibrinogen yog cov protein ntau soluble. Fibrin yog tsim los ntawm fibrinogen uas yog cov protein soluble hauv plasma. Fibrinogen hloov mus rau fibrin thaum muaj kev raug mob hauv vascular system. Qhov kev hloov pauv no yog catalyzed los ntawm cov enzymes hu ua thrombin. Thrombin converts fibrinogen rau hauv insoluble fibrin uas tsim nyog los ua ib lub network rau platelets rau cuab thiab tsim ib tug plug ntawm platelets. Ob leeg fibrin thiab fibrinogen yog tsim nyob rau hauv daim siab thiab tso rau hauv plasma.
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