Qhov Tseem Ceeb Qhov txawv - Dopamine vs Endorphins
Dopamine thiab Endorphin yog cov tshuaj lom neeg koom nrog hauv cov teeb liab kis mus rau hauv lub paj hlwb. Ob leeg yog hu ua neurotransmitters. Qhov sib txawv tseem ceeb ntawm Dopamine thiab Endorphin yog Dopamine yog ib qho me me molecule neurotransmitter uas yog lub luag haujlwm tseem ceeb rau kev txav thiab kev zoo siab thaum Endorphin yog ib qho loj molecule ntawm neuropeptide nrog lub luag haujlwm tseem ceeb ntawm kev mob nyem.
Dopamine yog dab tsi?
Dopamine (3, 4-dihydroxyphenethylamine) yog ib qho ntawm cov neurotransmitters synthesized los ntawm lub hauv paus paj hlwb. Nws ua feem ntau yog ib qho inhibitory neurotransmitter uas koom nrog hauv kev sib npaug ntawm lub hlwb stimulation los ntawm kev zoo siab tas mus li; nws qee zaum kuj ua raws li neurohormone. Dopamine (C8H11NO2) yog siv los ua tus ua ntej rau kev tsim cov neurotransmitters: norepinephrine thiab epinephrine. Cov tshuaj no tseem ceeb heev rau ntau lub luag haujlwm hauv tib neeg thiab tsiaj txhu. Qee lub luag haujlwm tseem ceeb ntawm dopamine suav nrog kev txaus siab rau qhov khoom plig, txav, pw tsaug zog, txhim kho kev nco, kho lub siab, ua kom pom tseeb thiab saib xyuas, tus cwj pwm, kev kawm, kev ua mob, kev tswj hwm ntawm prolactin secretion, thiab lwm yam.
Kev tuav tswj kom zoo ntawm dopamine hauv lub cev yog qhov tseem ceeb vim tias cov dopamine qis ua rau muaj ntau yam kab mob xws li Tourette's syndrome, schizophrenia, Parkinson's disease, Huntington's disease, kev quav tshuaj thiab kev nyuaj siab. Tus kab mob Parkinson yog ib yam kab mob hnyav uas tshwm sim los ntawm qhov tsis muaj dopamine. Nws yog ib qho teeb meem loj hauv lub paj hlwb uas cuam tshuam rau kev txav ntawm lub cev.
Figure_1: Cov qauv tshuaj ntawm Dopamine
Thaum Dopamine yog tsim los ntawm dopaminergic neurons raws li cov lus teb rau kev txhawb nqa thiab tso tawm rau cov tshuaj synapses, nws diffuses los ntawm cov synaptic cleft ntawm postsynaptic dopamine receptors. Muaj tsib dopamine receptors pom ntawm qhov kawg postsynaptic: D1, D2, D3, D4 thiab D5. Lawv ua qeeb metabotropic receptors ua ke nrog G proteins. Tom qab xa cov teeb liab tshuaj mus rau postsynaptic neuron, Dopamine tuaj yeem rov ua dua thiab rov ntim rau hauv cov hlab ntsha synaptic los ntawm presynaptic neuron lossis tuaj yeem degraded los ntawm cov enzymes.
Endorphins yog dab tsi?
Endorphins yog neuropeptides (ib hom neurotransmitters) uas kho cov teeb liab kis mus rau hauv lub paj hlwb. Synthesis thiab khaws cia ntawm endorphins feem ntau tshwm sim hauv cov qog pituitary. Endorphin (C45H66N10O15 S) tso tawm tsuas yog tshwm sim los ntawm kev tsim cov peev txheej los ntawm cov stimuli: kev ntxhov siab thiab mob. Muaj ntau lub luag haujlwm tseem ceeb tswj hwm los ntawm endorphins. Cov haujlwm no feem ntau suav nrog kev tswj kev mob, muaj cov tshuaj zoo li morphine thiab cov nqi zog ua haujlwm xws li kev sib deev, noj, haus, thiab lwm yam. Endorphin khi nrog inhibitory G protein-coupled receptors hu ua opioid receptors thiab txo qhov kev nkag siab ntawm qhov mob los ntawm inhibiting cov synthesis. proteins koom nrog hauv kev kis mob. Yog li, endorphins tuaj yeem suav hais tias yog tshuaj kho mob vim qhov mob tua muaj peev xwm. Thaum cov tshuaj endorphin secretions tsawg, nws ua rau tib neeg muaj kev ntxhov siab thiab raug mob ntau dua. Qib siab Endorphin txo qhov mob thiab ua rau koj zoo siab rau lub siab thiab lub cev. Endorphin secretion tuaj yeem tshwm sim los ntawm kev ua kom zoo, kev xav thiab los ntawm qee yam khoom noj.
Daim duab 2: Endorphin Structure
Dab tsi yog qhov txawv ntawm Dopamine thiab Endorphins?
Dopamine vs Endorphins |
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| Dopamine yog ib qho me me molecule monoamine neurotransmitter. | Endorphin yog ib qho loj dua molecule neuropeptide. |
| Tshuaj Formula | |
| C8H11NO2 | C45H66N10O15 S |
| Txhob Cia Siab | |
| G protein-coupled D1 - D5 receptors | G protein-coupled opioid receptors |
| Lub cev muaj nuj nqi | |
| Lub luag haujlwm tseem ceeb suav nrog kev txav lub cev, kev zoo siab thiab kev txhawb siab | Cov haujlwm tseem ceeb ntawm cov nyiaj tau los thiab kov yeej kev ntxhov siab thiab mob nyem. |
| kho mob | |
| Qhov no tuaj yeem ua rau Tourette's syndrome, Parkinson's disease, kev quav yeeb tshuaj, kev nyuaj siab, thiab lwm yam. | Qhov no tuaj yeem ua rau muaj kev ntxhov siab, kev nyuaj siab, thiab obsessive-compulsive teeb meem, thiab lwm yam. |
Summary – Dopamine vs Endorphins
Dopamine thiab Endorphin yog cov neurotransmitters uas koom nrog cov neurotransmitter pawg ntawm monoamines thiab neuropeptides, feem. Dopamine yog catecholamine thaum Endorphin yog ib qho loj molecule - cov protein me me uas muaj peptides. Ob leeg neurotransmitters koom nrog kev zoo siab thiab kev zoo siab, tab sis, endorphins feem ntau yog lub luag haujlwm rau kev txo qis ntawm qhov mob thiab dopamine yog lub luag haujlwm rau lub cev txav. Qhov no yog qhov sib txawv tseem ceeb ntawm Dopamine thiab Endorphins. Ob yam tshuaj no tuaj yeem raug hu ua tshuaj lom neeg zoo siab.
