Qhov Tseem Ceeb Qhov txawv - Serotonin vs Endorphins
Serotonin thiab Endorphin yog inhibitory neurotransmitters siv los ntawm lub paj hlwb kom xa cov teeb liab los ntawm ib qho neuron mus rau lwm tus neuron thiab tswj kev sib txuas zoo ntawm cov paj hlwb. Qhov sib txawv tseem ceeb ntawm Serotonin thiab Endorphin yog tias Serotonin yog monoamine neurotransmitter thaum Endorphin yog cov protein me me uas muaj cov molecule loj. Ob leeg neurotransmitters yog lub hauv paus hu ua kev zoo siab molecules lossis cov tshuaj zoo siab.
YSerotonin yog dab tsi?
Serotonin, tseem hu ua 5-hydroxytryptamine, yog ib qho neurotransmitter uas koom nrog hauv cov tshuaj lom neeg cov teeb liab kis mus rau cov hlab ntsha hauv cov hlab ntsha. Nws yog monoamine, muaj cov tshuaj formula ntawm C10H12N2O raws li qhia hauv daim duab 01. Serotonin yog synthesized los ntawm serotonergic neurons nyob rau hauv lub hlwb thiab feem ntau pom nyob rau hauv lub plab hnyuv kab mob, cov ntshav platelets thiab lub hauv paus paj hlwb ntawm tib neeg thiab lwm yam tsiaj. Feem ntau ntawm cov serotonins tau sib sau ua ke hauv plab hnyuv vim nws lub luag haujlwm tseem ceeb yog cuam tshuam nrog GI ib puag ncig (kev tswj hwm txoj hnyuv). Tryptophan (ib qho amino acid) yog qhov ua ntej siv rau biosynthesis ntawm serotonin thiab cov txheej txheem zoo ib yam li kev tsim cov tshuaj Dopamine. Synthesized serotonins tau ntim thiab khaws cia rau hauv cov hlab ntsha synaptic ntawm axon davhlau ya nyob twg (presynaptic kawg ntawm cov neuron). Thaum lub presynaptic neuron tau txais ib qho kev muaj peev xwm los ntawm kev txhawb nqa, nws tso tawm serotonins mus rau synaptic cleft ntawm cov tshuaj synapse. serotonins diffuse los ntawm lub cleft thiab khi rau serotonergic receptors hu ua 5-HT receptors nyob rau ntawm daim nyias nyias ntawm lub postsynaptic neuron (tsuas yog nyob rau ntawm lub dendrites) thiab xa cov teeb liab mus rau nws. Serotonins yog lub luag haujlwm rau kev ua haujlwm sib txawv hauv lub cev xws li carbohydrate cravings, pw tsaug zog, tswj qhov mob, kev zom zaub mov zoo, kev coj tus cwj pwm, kev qab los noj mov, nco thiab kev sib deev, thiab kev ua haujlwm, thiab lwm yam.
Serotonin qhov kev txiav txim yog nyob rau hauv inhibitory pawg ntawm neurotransmitters vim nws tsis txhawb lub hlwb. Qhov no txhais tau hais tias serotonin koom nrog hauv kev ua kom lub siab nyob ruaj khov thiab sib npaug ntawm lub hlwb ntau dhau. Qib qis ntawm serotonin yuav ua rau muaj kev nyuaj siab, ntxhov siab, npau taws thiab kev kho siab. Ib tug loj npaum li cas ntawm serotonin yuav ua rau koj zoo siab thiab ua rau koj so. Cov serotonin ntau dhau yuav ua rau muaj tus mob hu ua serotonin syndrome.
Serotonin kev tsim khoom tuaj yeem txhim kho los ntawm ntau yam uas cuam tshuam txog kev tsim cov tryptophan. Cov no yog cov zaub mov noj qab haus huv, tshuaj noj, kev tawm dag zog, hnub ci, thiab lwm yam. Kev nyuaj siab vim qis qis ntawm serotonin hauv lub cev tuaj yeem kov yeej los ntawm kev noj cov tshuaj serotonin reuptake inhibitors (SSRI). Nws yog ib qho tshuaj antidepressant feem ntau sau los ntawm kws kho mob. SSRI yuav inhibit qhov kev rov ua dua ntawm serotonin los ntawm presynaptic neurons thiab nce cov haujlwm ntawm serotonin los khi rau 5-HT receptors ntawm postsynaptic neuron.
Figure_01: Cov qauv ntawm Serotonin
Endorphins yog dab tsi?
Endorphins yog lwm hom neurotransmitters (uas yog nyob rau hauv pawg neuropeptide) koom nrog cov teeb liab tshuaj lom neeg los ntawm cov tshuaj synapses hauv lub paj hlwb. Lawv yog cov protein me me uas muaj qhov hnyav dua molecular peptides (C45H66N10O 15S) raws li qhia hauv daim duab 02. Endorphins feem ntau pom nyob rau hauv pituitary caj pas thiab lub hlwb. Nws yog lub luag haujlwm tseem ceeb ntawm cov tshuaj tua kab mob (txo cov kev nkag siab ntawm qhov mob). Txij li thaum Endorphins ua raws li cov tshuaj tua kab mob, lawv tuaj yeem suav tias yog tshuaj tua kab mob zoo ib yam li morphine thiab codeine. Cov cuab yeej no yog vim qhov inhibition ntawm protein synthesis uas yog lub luag haujlwm rau kev mob kis los ntawm lub cev. Endorphins khi rau opioid receptors nyob rau ntawm postsynaptic neurons thiab inhibit qhov kev sib kis ntawm qhov mob.
Endorphins muaj ntau lub luag haujlwm hauv lub cev nrog rau txo qhov mob thiab kev ntxhov siab, txhim kho lub cev tiv thaiv kab mob, kev tswj hwm kev ua haujlwm zoo thiab lwm yam. Endorphins yog inhibitory neurotransmitters tam sim no nyob rau hauv lub paj hlwb kho lub siab thiab ua kom lub hlwb. Kev ntxhov siab thiab mob yog lub luag haujlwm tseem ceeb rau kev tso tawm Endorphin. Endorphins raug tso tawm rau hauv lub synaptic cleft thiab taug kev los ntawm qhov nruab nrab thiab khi nrog opioid receptors ntawm postsynaptic kawg. Kev khi ntawm endorphins rau receptors yuav inhibit qhov tsim ntawm qhov ua tau zoo, ua rau daim nyias nyias muaj peev xwm tsis zoo.
Kev tswj hwm qib Endorphin hauv lub cev yog qhov tseem ceeb vim tias qib qis tshwm sim los ntawm cov xwm txheej sib txawv xws li kev nyuaj siab, tsis kam ua rau mob, tsis muaj kev txaus siab, mob ntev, thiab lwm yam. Endorphin ntau lawm tuaj yeem raug ntxias los ntawm kev tawm dag zog kom zoo, xav txog, qee yam khoom noj, acupuncture, thiab lwm yam.
Figure_2: Cov qauv ntawm Endorphin
Dab tsi yog qhov txawv ntawm Serotonin thiab Endorphins
Serotonin vs Endorphins |
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| Serotonin yog ib qho me me molecule monoamine neurotransmitter. | Endorphin yog ib qho protein me me uas ua los ntawm peptides (neuropeptide). |
| Serotonin muaj nyob hauv plab hnyuv. | Endorphins muaj nyob hauv pituitary caj pas. |
| Lub luag haujlwm tseem ceeb | |
| Serotonin tswj lub siab sib npaug. | Endorphins txo qhov kev xav ntawm qhov mob. |
| Txoj kev txais tos | |
| 5-HT receptors ua raws li kev khi receptors | Opioid receptors ua raws li kev khi receptors |
Summary – Serotonin vs Endorphins
Txawm hais tias qhov sib txawv ntawm Serotonin thiab Endorphin, ob leeg yog inhibitory neurotransmitters lub luag haujlwm rau kev kho lub siab thiab ntsuas lub hlwb stimulations. Ob leeg tuaj yeem pab tib neeg kom muaj kev zoo siab thiab txo qhov mob. Xav txog lub luag haujlwm tseem ceeb ntawm cov tshuaj neurotransmitters, Serotonin tuaj yeem paub tias yog tshuaj zoo rau lub siab thaum Endorphin yog cov tshuaj kho mob uas pom hauv peb lub paj hlwb.
