Qhov sib txawv tseem ceeb ntawm cov tshuaj steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob yog cov tshuaj steroidal anti-inflammatory tshuaj inhibit phospholipase A2 enzyme los thaiv cov kab mob inflammatory thaum cov tshuaj nonsteroidal anti-inflammatory inhibit cyclooxygenase enzyme los thaiv cov kab mob inflammatory.
Steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob yog ob hom tshuaj sib txawv muaj nyob hauv khw los txo qhov mob hauv tib neeg lub cev vim yog qhov sib txawv. Lawv tau siv dav hauv tshuaj. Ntxiv mus, ob qho tib si ntawm cov molecules no thaiv cov teebmeem ntawm cov tshuaj hauv lub cev hu ua prostaglandins uas txhawb kev mob, ua npaws, thiab mob.
Dab tsi yog Steroidal Anti-inflammatory Drug?
Steroidal anti-inflammatory tshuaj yog ib hom tshuaj tiv thaiv kab mob siv los txo qhov mob hauv tib neeg lub cev. Cov tshuaj no inhibit phospholipase A2 enzyme los thaiv cov kab mob inflammatory. Phospholipases, ib qho ntawm cov khoom tseem ceeb tso tawm thaum mob, tau hloov mus rau arachidonic acid sai sai los ntawm phospholipase A2. Tom qab ntawd, arachidonic acid tuaj yeem nkag mus rau ob sab caj npab sib txawv ntawm cov kab mob inflammatory. Los ntawm kev ua raws li txoj kev, nws tuaj yeem hloov mus rau prostaglandins los ntawm enzyme cyclooxygenase. Los ntawm kev ua raws li lwm txoj hauv kev, nws tuaj yeem hloov mus rau leukotrienes los ntawm enzyme lipooxygenase. Steroidal anti-inflammatory tshuaj thaiv ob txhais caj npab ntawm lub inflammatory cascade.
Daim duab 01: Cov Tshuaj Steroidal Anti-inflammatory Drugs
Steroids tshuaj tiv thaiv kab mob txo qis vasopermeability, redness, edema, thiab mob. Tsis tas li ntawd, lawv muaj qhov zoo dua ntxiv vim lawv khaws cov leukocytes sequestered los ntawm qhov chaw ntawm qhov mob los ntawm kev thaiv cov lipooxygenase caj npab ntawm cov kab mob inflammatory. Cov tshuaj steroids los tiv thaiv kab mob tuaj yeem los ntawm cov tsiaj, nroj tsuag, thiab tib neeg qhov chaw. Lawv tuaj yeem tsim los ntawm kev sib deev steroids, corticosteroids, thiab anabolic steroids. Nyob rau hauv cov ntaub ntawv ntawm corticosteroids, lawv yog siv nyob rau hauv ntau yam mob, nrog rau cov kab mob ntawm daim tawv nqaij, hormonal tsis txaus, thiab qog. Corticosteroids kuj tseem siv rau hauv kev kho mob pob qij txha thiab o. Txawm li cas los xij, lawv muaj cov tshuaj narcotic thiab tej zaum yuav dhau los ua cov tshuaj yeeb tshuaj rau cov neeg mob.
Cov tshuaj uas tsis yog tshuaj tiv thaiv steroidal yog dab tsi?
Nonsteroidal anti-inflammatory tshuaj (NSAIDs) inhibit cyclooxygenase enzymes los ntawm thaiv cov inflammatory cascade. Lawv thaiv tsuas yog ib sab caj npab ntawm inflammatory cascade. Nonsteroidal anti-inflammatory tshuaj yog cov tswv cuab ntawm cov tshuaj tiv thaiv kab mob uas txo qhov mob, mob, thiab kub taub hau, thiab tiv thaiv cov ntshav txhaws. NSAIDs ua los ntawm inhibiting enzyme kev ua ntawm cyclooxygenase (COX 1 thiab COX2). Hauv cov hlwb, cov enzyme no koom nrog hauv kev sib txuas ntawm cov tshuaj lom neeg lom neeg tseem ceeb hu ua prostaglandins thiab thromboxanes, uas cuam tshuam rau kev mob thiab ntshav txhaws, feem.
Daim duab 02: Nonsteroidal Anti-inflammatory Drugs
Cov kev mob tshwm sim ntawm cov tshuaj uas tsis yog tshuaj tiv thaiv kab mob yog xeev siab, ntuav, ua xua, mob plab hnyuv, los ntshav, ntshav ntshav, plawv nres, thiab kab mob raum. Qee cov NSAIDs tseem ceeb tshaj plaws yog cov tshuaj aspirin, ibuprofen, thiab naproxen. Lawv txhua tus muaj nyob hauv lub txee hauv ntau lub tebchaws.
Dab tsi zoo sib xws ntawm Cov Tshuaj Steroidal thiab Nonsteroidal Anti-inflammatory Drugs?
- Cov tshuaj Steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob yog ob hom tshuaj sib txawv muaj nyob hauv khw los txo qhov mob hauv tib neeg lub cev vim muaj qhov sib txawv.
- Ob chav tshuaj tuaj yeem txo qhov mob, mob, thiab ua npaws.
- Lawv muaj kev phiv.
- Lawv tau yooj yim muaj nyob hauv khw.
Qhov txawv ntawm Steroidal thiab Nonsteroidal Anti-inflammatory Drug yog dab tsi?
Steroidal tshuaj tiv thaiv kab mob inhibit phospholipase A2 enzyme los ntawm kev thaiv cov kab mob inflammatory, thaum cov tshuaj nonsteroidal anti-inflammatory inhibit cyclooxygenase enzyme los thaiv cov kab mob inflammatory. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm steroidal thiab nonsteroidal anti-inflammatory tshuaj. Tsis tas li ntawd, steroidal anti-inflammatory tshuaj thaiv ob txhais caj npab ntawm lub inflammatory cascade, thaum nonsteroidal anti-inflammatory tshuaj thaiv tsuas yog ib sab caj npab ntawm inflammatory cascade.
Cov hauv qab no qhia txog qhov sib txawv ntawm cov tshuaj steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – Steroidal vs Nonsteroidal Anti-inflammatory Drugs
Steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob yog ob hom tshuaj tiv thaiv kab mob tseem ceeb. Steroidal anti-inflammatory tshuaj inhibit phospholipase A2 los ntawm kev thaiv cov inflammatory cascade. Nonsteroidal anti-inflammatory tshuaj inhibit cyclooxygenase enzyme los ntawm kev thaiv cov inflammatory cascade. Yog li, qhov no qhia txog qhov sib txawv ntawm steroidal thiab nonsteroidal tshuaj tiv thaiv kab mob.
