Qhov sib txawv tseem ceeb ntawm kev tiv thaiv-CCP thiab ACPA yog qhov kev tiv thaiv-CCP yog ib feem ntawm ACPA muaj txiaj ntsig zoo li tus cim autoantibody txhawm rau txheeb xyuas cov neeg mob rheumatoid mob caj dab, thaum ACPA yog ib pawg loj ntawm autoantibodies.
Autoantibodies yog ib hom tshuaj tiv thaiv uas tsim los ntawm lub cev tiv thaiv kab mob ntawm lub cev tawm tsam nws cov proteins. Qhov no feem ntau tshwm sim thaum cov tshuaj tiv thaiv inflammatory. Cov xwm txheej zoo li no tshwm sim hauv rheumatoid mob caj dab. autoantibodies ua rau cov kab mob autoimmune uas lub cev tiv thaiv kab mob tawm tsam nws tus kheej vim kev txhais lus tsis raug ntawm antigens. ACPA thiab Anti-CCP yog ob hom autoantibodies, uas muaj ntau yam ntxwv. Ob lub autoantibodies no ua lub luag haujlwm tseem ceeb hauv kev tshawb pom ntxov ntawm rheumatoid mob caj dab.
Anti-CCP yog dab tsi?
Anti-CCP lossis anti-cyclic citrullinated peptides yog ib hom autoantibodies uas muab cov cim qhia ntawm mob caj dab rheumatoid. Lawv yog ib qho subset ntawm ACPA thiab tsis yog cross-reactive nrog rau lwm cov citrullinated proteins. Anti-CCP tsom cov ntaub so ntswg noj qab nyob zoo hauv cov pob qij txha thiab ua rau mob rheumatoid mob caj dab. Nws yog ib hom kab mob autoimmune uas ua rau mob thiab o ntawm cov pob qij txha. Clinically nws tau pom tias 75 feem pua ntawm cov neeg mob uas mob rheumatoid mob caj dab muaj anti-CCP hauv lawv cov ntshav.
Daim duab 01: Rheumatoid Arthritis
Anti-CCP kuaj pab kuaj mob rheumatoid mob caj dab thiab qib ntawm kev loj hlob. Qhov no feem ntau ua nrog rau kev kuaj mob rheumatoid (RF). Txawm li cas los xij, lub xub ntiag ntawm RF tsis lees paub qhov kev txhim kho ntawm rheumatoid mob caj dab vim tias RF yam tseem ceeb muaj rau lwm cov kab mob autoimmune thiab cov neeg noj qab haus huv. Anti-CCP muab kev kuaj pom tseeb ntawm rheumatoid mob caj dab piv nrog RF kuaj.
ACPA yog dab tsi?
ACPA lossis anti-citrullinated protein antibodies ncaj qha tiv thaiv kev tshawb pom ntawm citrullinated proteins thiab peptides. ACPAs yog autoantibodies, txhais tau tias lawv yog cov tshuaj tiv thaiv rau tus kheej cov proteins. ACPAs muaj nyob rau hauv cov neeg mob uas muaj mob rheumatoid mob caj dab. Yog li ntawd, nws yog ib tug muaj zog biomarker los soj ntsuam tus kab mob nyob rau hauv cov theem pib heev. Nyob rau hauv cov ntaub ntawv kho mob, immunologists siv cyclic citrullinated peptides (CCP) los kuaj ACPAs hauv cov neeg mob ntshav ntshav thiab ntshav.
Thaum muaj kev mob tshwm sim xws li mob caj dab, arginine amino acid residues muaj peev xwm hloov mus rau citrulline residues enzymatically hauv cov proteins xws li vimentin. Cov txheej txheem ntawm kev hloov pauv no yog citrullination. Thaum lub sij hawm citrullination, yog tias cov qauv protein tau hloov pauv loj heev, cov tib neeg lub cev tiv thaiv kab mob yuav pom cov protein hloov pauv no ua antigens thiab tsim cov tshuaj tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob no yog cov lus teb autoimmune, uas ua rau cov kab mob autoimmune.
Qhov Zoo sib xws ntawm Kev Tiv Thaiv-CCP thiab ACPA yog dab tsi?
- Anti-CCP thiab ACPA yog autoantibodies.
- Ob hom yog tsim los ntawm tib neeg lub cev tiv thaiv kab mob.
- Lawv tsom tib neeg tus kheej cov proteins.
- Ntxiv mus, ob leeg tuaj yeem ua raws li biomarkers.
- ob leeg yog citrullinated proteins.
- Anti-CCP thiab ACPA yog siv rau kev tshawb pom ntxov ntawm rheumatoid mob caj dab.
- Anti-CCP thiab ACPA raug kuaj pom hauv tib lub sera.
Qhov txawv ntawm Anti-CCP thiab ACPA yog dab tsi?
Qhov sib txawv tseem ceeb ntawm kev tiv thaiv CCP thiab ACPA yog qhov kev tiv thaiv CCP yog ib feem ntawm ACPA uas suav nrog autoantibodies, thaum ACPA yog ib pawg loj ntawm autoantibodies. Anti-CCP stands rau anti-cyclic citrullinated peptide, thaum ACPA stands rau anti-citrullinated protein cov tshuaj tiv thaiv. Ntxiv mus, qhov kev ntsuam xyuas los tiv thaiv CCP pom cov tshuaj tiv thaiv CCP autoantibodies, thaum ELISA kuaj pom ACPA autoantibodies.
Cov hauv qab no qhia txog qhov sib txawv ntawm kev tiv thaiv CCP thiab ACPA hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Anti-CCP vs ACPA
Autoantibodies yog ib hom tshuaj tiv thaiv uas tsim los ntawm lub cev tiv thaiv kab mob ntawm lub cev tiv thaiv nws tus kheej cov proteins thaum muaj kev kub ntxhov. Anti-CCPs (anti-cyclic citrullinated peptides) yog ib hom autoantibodies uas qhia txog kev mob caj dab rheumatoid. Lawv yog ib feem ntawm ACPA thiab tsis yog cross-reactive nrog rau lwm cov citrullinated proteins. ACPA lossis anti-citrullinated protein antibodies ncaj qha tiv thaiv kev tshawb pom ntawm citrullinated proteins thiab peptides. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm kev tiv thaiv CCP thiab ACPA. Ob qho tshuaj tiv thaiv CCP thiab ACPA yog siv rau kev tshawb pom ntxov ntawm rheumatoid mob caj dab vim lawv ua haujlwm zoo li biomarkers muaj zog.
