Qhov sib txawv tseem ceeb ntawm paraganglioma thiab pheochromocytoma yog paraganglioma yog cov qog qog adrenal uas tsim tawm sab nraud lub qog adrenal, thaum pheochromocytoma yog qog qog adrenal uas tsim nyob hauv nruab nrab ntawm lub qog adrenal.
Paraganglioma thiab pheochromocytoma yog ob hom qog nqaij hlav qog adrenal. Cov qog qog adrenal yog cov qog nqaij hlav qog nqaij hlav lossis tsis muaj qog nqaij hlav ntawm cov qog adrenal. Qhov ua rau feem ntau ntawm cov qog no tsis paub. Cov kev pheej hmoo rau cov qog adrenal muaj xws li Carey complex, Li-Fraumeni syndrome, ntau yam endocrine neoplasia hom 2, thiab neurofibromatosis hom 1.
Paraganglioma yog dab tsi?
Paraganglioma yog qog qog adrenal uas tsim tawm sab nraud ntawm lub qog adrenal. Nws yog ib hom kab mob neuroendocrine uas tsim nyob ze qee cov hlab ntsha thiab cov hlab ntsha sab nraud ntawm cov qog adrenal. Cov qog adrenal yog nyob rau sab saum toj ntawm lub raum. Lawv ua ntau lub luag haujlwm tseem ceeb, suav nrog kev tsim cov tshuaj hormones uas tswj ntau lub luag haujlwm hauv tib neeg lub cev. Cov hlab ntsha cuam tshuam nyob rau hauv cov ntaub ntawv ntawm paraganglioma yog ib feem ntawm lub paj hlwb peripheral. Nws txhais tau tias cov hlab ntsha no yog ib feem ntawm lub paj hlwb sab nraum lub hlwb thiab qaum qaum. Ntxiv mus, kwv yees li 35-50% ntawm paraganglioma tuaj yeem kis mus rau lwm qhov ntawm lub cev.
Daim duab 01: Paraganglioma
Cov tsos mob ntawm tus qog no muaj xws li ntshav siab, tawm hws, plawv dhia, mob pob txha, hnov lus, tinnitus, ntxhov siab vim, thiab mob taub hau. Kwv yees li ib ntawm plaub tus kab mob paragangliomas tau txais txiaj ntsig. Qhov tsis xws luag hauv cov noob xws li succinate dehydrogenase subunits B (SDHB), C (SDHC), thiab D (SDHD) yog txuas rau tsev neeg paraganglioma. Kev hloov pauv hauv RET gene kuj yog ib qho genetic ua rau paraganglioma.
Paraganglioma yog kuaj los ntawm kev kuaj zis, kuaj ntshav, CT-scans, MRIs, metaiodobenzylguanidine (MIBG) scans, PET scans, thiab kuaj caj ces. Tsis tas li ntawd, cov kev xaiv kho mob yuav suav nrog cov tshuaj ntshav siab (phenoxybenzamine, doxazosin, lossis propranolol), cov tshuaj hormone ntau lawm tswj cov tshuaj (alpha-blockers, beta-blockers, calcium channel blockers), kev phais, kev kho mob nuclear xws li radioactive MIBG lossis octreotide, Thermal ablation therapy, chemotherapy, thiab kev siv tshuaj kho mob.
Pheochromocytoma yog dab tsi?
Pheochromocytoma yog cov qog qog adrenal uas tsim nyob hauv nruab nrab ntawm cov qog adrenal. Nws yog ib qho qog tsis tshua muaj ntawm adrenal medulla tsim los ntawm chromaffin hlwb (pheochromocytes). Cov qog neuroendocrine no muaj peev xwm tsim tau thiab tso tawm ntau ntawm catecholamines, metanephrines, thiab methoxytyramine. Cov tsos mob ntawm tus mob no yuav muaj xws li mob taub hau, kub siab, tachycardia, diaphoresis (tawm hws ntau dhau, hyperhidrosis (tawm hmo ntuj), kev tawm dag zog lub cev, kev ntxhov siab, kev tawm tsam, kev raug mob, pallor, kub tsis haum, hauv siab lossis plab tsis xis nyob, xeev siab, ntuav, cem quav, Cov kab mob pheochromocytoma tuaj yeem tshwm sim vim kev hloov pauv ntawm cov noob xws li RET, VHL, thiab NF1. Lwm cov noob hloov pauv uas tuaj yeem ua rau pheochromocytoma suav nrog MAX thiab TMEM127.
Daim duab 02: Pheochromocytoma
Pheochromocytoma tuaj yeem kuaj tau los ntawm kev kuaj zis 24-teev, kuaj ntshav, kuaj cov duab (CT-scan, MRI, MIBG scan, PET scan), lossis kuaj caj ces. Tsis tas li ntawd, cov kev kho mob yuav suav nrog alpha-blockers, beta-blockers kom txo cov ntshav siab, noj ntsev ntau (tiv thaiv cov ntshav siab poob qis), kev phais, MIBG hluav taws xob kho, peptide receptor radiation therapy (PRRT), chemotherapy, hluav taws xob kho, thiab hom phiaj kho mob cancer.
Dab tsi zoo sib xws ntawm Paraganglioma thiab Pheochromocytoma?
- Paraganglioma thiab pheochromocytoma yog ob hom qog qog adrenal.
- Ob lub qog no tsawg thiab qeeb qeeb.
- 30-40% ntawm ob lub qog tau txais.
- Ob leeg qog yog catecholamine-ua cov qog neuroendocrine.
- Lawv qhia cov tsos mob xws li ntshav siab, tawm hws, thiab mob taub hau.
- Lawv muaj cov xwm txheej pheej hmoo xws li ntau yam endocrine neoplasia hom 2, Von Hipple-Lindau kab mob, thiab neurofibromatosis (NF1).
- Lawv muaj cov txheej txheem kuaj mob zoo sib xws.
- Lawv tuaj yeem kho tau los ntawm kev siv tshuaj khomob, kho hluav taws xob, thiab kev phais tshwj xeeb.
Qhov txawv ntawm Paraganglioma thiab Pheochromocytoma yog dab tsi?
Paraganglioma yog qog qog adrenal uas tsim tawm sab nraud lub qog adrenal, thaum pheochromocytoma yog qog qog adrenal uas tsim nyob hauv nruab nrab ntawm lub qog adrenal. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm paraganglioma thiab pheochromocytoma. Tsis tas li ntawd, paraganglioma tuaj yeem tshwm sim vim muaj kev hloov pauv hauv cov noob xws li SDHB, SDHC, thiab SDHD, thaum pheochromocytoma tuaj yeem tshwm sim vim muaj kev hloov pauv hauv cov noob xws li RET, VHL, thiab NF1, MAX, thiab TMEM127.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm paraganglioma thiab pheochromocytoma hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Paraganglioma vs Pheochromocytoma
Paraganglioma thiab pheochromocytoma yog ob hom qog nqaij hlav qog adrenal. Ob leeg qog nqaij hlav yog catecholamine-ua cov qog neuroendocrine. Paraganglioma qog hlav tawm sab nraum lub qog adrenal, thaum pheochromocytoma qog tsim nyob rau hauv nruab nrab ntawm lub qog adrenal. Yog li, qhov no qhia txog qhov txawv ntawm paraganglioma thiab pheochromocytoma
