Qhov sib txawv tseem ceeb ntawm penicillinase thiab beta lactamase yog penicillinase yog ib hom beta lactamas uas qhia tshwj xeeb rau penicillin, thaum beta lactamas yog ib pawg enzymes tsim los ntawm cov kab mob uas tsim muaj ntau yam ua rau cov tshuaj tua kab mob beta-lactam xws li xws li penicillin, cephalosporin, cephamycin, thiab monobactam.
Tshuaj tiv thaiv kab mob yog ib qho kev txhawj xeeb loj hauv ntiaj teb niaj hnub no. Beta lactamase yog ib pab pawg enzymes tsim los ntawm cov kab mob ua rau cov tshuaj tiv thaiv kab mob rau ntau hom tshuaj tua kab mob hauv pawg beta lactam. Cov enzymes no hydrolyze lub nplhaib beta lactam ntawm cov tshuaj tua kab mob tshwj xeeb thiab ua rau nws tsis muaj txiaj ntsig. Penicillinase yog ib yam tshwj xeeb ntawm beta lactamases thiab yog thawj hom beta lactamase enzyme txheeb xyuas.
Penicillinase yog dab tsi?
Penicillinase yog ib hom beta lactamases enzyme uas tsim los ntawm cov kab mob uas ua rau cov tshuaj tiv thaiv penicillin tshuaj tua kab mob thiab rhuav tshem cov tshuaj tua kab mob ntawm cov tshuaj. Penicillinase qhia tshwj xeeb rau penicillin. Qhov enzyme no ua rau cov tshuaj tiv thaiv kab mob los ntawm hydrolysis ntawm beta lactam nplhaib tam sim no hauv penicillin. Qhov hnyav molecular ntawm penicillinase txawv thiab feem ntau yog nyob ib ncig ntawm 50 kilo D altons.
Daim duab 01: Daim Ntawv Thov Penicillinase
Penicillinase yog thawj hom beta lactamas tau txheeb xyuas thiab raug cais tawm ntawm gram-negative Escherichia coli los ntawm Abraham thiab Chain hauv xyoo 1940. Qhov no yog ua ntej kev kho mob siv penicillin ua tshuaj tua kab mob. Tom qab kev txheeb xyuas, nws tau pom tias kev tsim cov tshuaj penicillinase feem ntau tshwm sim hauv lwm cov kab mob tom qab qee lub sijhawm thiab ua rau cov tshuaj tiv thaiv penicillin. Cov kws tshawb fawb tau tsim cov tshuaj tua kab mob penicillinase-resistant beta lactam xws li methicillin, tab sis thaum kawg lawv tau los tiv thaiv vim muaj cov kab mob tiv thaiv kab mob ntau yam (tshwj xeeb yog cov tshuaj tua kab mob beta lactam).
Beta Lactamase yog dab tsi?
Beta lactamas yog ib pawg enzymes muab faib ua cuaj chav kawm. Lawv raug tsim los ntawm cov kab mob uas ua rau muaj kev tawm tsam ntawm beta lactam tshuaj tua kab mob, uas yog cov tshuaj tua kab mob uas rhuav tshem cov tshuaj tua kab mob ntawm cov tshuaj. Cov enzymes no ua rau muaj kev tiv thaiv ntau rau cov tshuaj tua kab mob beta lactam xws li penicillin, cephalosporin, cephamycin, monobactam, thiab carbapenem. Cov tshuaj tua kab mob beta lactam muaj ib qho qauv hu ua beta lactam nplhaib hauv lawv cov qauv. Lub nplhaib beta lactam no yog hydrolyzed los ntawm beta lactamas enzymes, ua rau muaj kev cuam tshuam ntawm cov tshuaj tiv thaiv kab mob los ntawm kev ua haujlwm ntawm cov molecules uas muaj cov tshuaj tua kab mob.
Daim duab 02: Beta Lactamase Mechanism
Txhua cov tshuaj tua kab mob beta lactam tsom cov kab mob broad-spectrum uas muaj rau ob pawg gram-negative thiab gram-positive. Yog li, qhov kev txiav txim ntawm beta lactamases ua rau muaj ntau yam tshuaj tiv thaiv rau ntau hom kab mob. Qhov kwv yees molecular hnyav ntawm beta lactamas yog 29.8 kilo D altons. Cov hom tseem ceeb ntawm beta lactamases muaj xws li TEM beta-lactamases (chav kawm A), SHV beta-lactamases (chav kawm A), CTX-M beta-lactamases (chav kawm A), thiab OXA beta-lactamases (chav kawm D). Raws li hom beta lactamas, lub tshuab qhib lub nplhaib beta lactam ntawm cov tshuaj tua kab mob sib txawv.
Dab tsi zoo sib xws ntawm Penicillinase thiab Beta Lactamase?
- Penicillinase thiab beta lactamas yog enzymes.
- YLawv yog cov protein.
- Cov kab mob ua rau penicillinase thiab beta lactamase.
- Ob hom muaj kev koom tes hauv cov tshuaj tua kab mob microbial.
- Ntxiv mus, ob qho tib si hydrolyze beta lactam rings.
- Ob hom ua rau tshuaj tua kab mob tiv thaiv kab mob beta lactam tshuaj tua kab mob.
Qhov txawv ntawm Penicillinase thiab Beta Lactamase yog dab tsi?
Penicillinase yog ib hom beta lactamase uas qhia tshwj xeeb rau penicillin thaum beta lactamase yog ib pawg ntawm cov enzymes tsim los ntawm cov kab mob uas tsim muaj ntau yam ua rau cov tshuaj tua kab mob beta-lactam xws li penicillin, cephalosporin, cephamycin, thiab monobactam. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm penicillinase thiab beta lactamases. Ntxiv mus, qhov hnyav molecular ntawm penicillinase thiab beta lactamases yog kwv yees li 50-kilo D altons thiab 28.9-kilo D altons, feem. Tsis tas li ntawd, hydrolysis ntawm beta lactam nplhaib ntawm cov tshuaj tua kab mob tshwm sim nyob rau hauv sib txawv mechanisms nrog rau siv rau beta lactamas. Tab sis hauv penicillinase, nws hydrolyses cov amide bonds ntawm beta-lactam nplhaib.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm penicillinase thiab beta lactamase hauv daim ntawv qhia rau ib sab ntawm kev sib piv.
Summary – Penicillinase vs Beta Lactamase
Tshuaj tiv thaiv kab mob yog ib qho kev txhawj xeeb loj hauv ntiaj teb niaj hnub no. Penicillinase yog ib hom beta lactamase uas qhia tau hais tias tshwj xeeb rau penicillin, thaum beta lactamas yog ib pawg ntawm cov enzymes tsim los ntawm cov kab mob uas tsim muaj ntau yam ua rau cov tshuaj tua kab mob beta-lactam xws li penicillin, cephalosporin, cephamycin, monobactam. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm penicillinase thiab beta lactamases. Beta lactamase yog ib pab pawg enzymes uas tsim los ntawm cov kab mob uas ua rau muaj kev tawm tsam ntawm beta lactam tshuaj tua kab mob, uas yog cov tshuaj tua kab mob uas rhuav tshem cov tshuaj tua kab mob ntawm cov tshuaj.
