Qhov sib txawv tseem ceeb ntawm hemophilia A thiab B thiab C yog hemophilia A yog vim qhov tsis txaus ntawm cov ntshav txhaws VIII, thaum hemophilia B yog vim qhov tsis txaus ntawm cov ntshav txhaws IX thiab hemophilia C yog vim qhov tsis txaus ntawm XI.
Hemophilia A thiab B yog vim muaj qhov sib txuas ntawm X-txuas rov qab zoo nrog cov noob tsis zoo nyob ntawm X chromosome. Txiv neej muaj ib tug X chromosome, thiab poj niam muaj ob X chromosomes. Hauv cov txiv neej, tus neeg mob hemophilia muaj cov noob tsis zoo ntawm X chromosome. Yog li ntawd, feem ntau cov neeg mob hemophilia yog txiv neej. Hemophilia C tsis ua raws li cov qauv X-txuas txij li qhov kev hloov pauv tshwm sim hauv cov noob nyob rau ntawm chromosome 4. Yog li ntawd, hemophilia C cuam tshuam rau ob leeg poj niam txiv neej sib npaug.
Hemophilia A yog dab tsi?
Hemophilia A yog ib hom kab mob los ntshav uas tshwm sim los ntawm qhov tsis muaj ntshav txhaws VIII. Factor VIII tseem ceeb heev rau cov txheej txheem ntshav txhaws. Thaum qhov kev txiav me me lossis los ntshav raug mob tshwm sim, muaj kev cuam tshuam tshwm sim los pab cov ntshav txhaws. Cov txheej txheem no hu ua coagulation cascade. Nws suav nrog cov protein tshwj xeeb hu ua coagulation yam. Factor VIII yog ib qho zoo li coagulation. Cov chaw tseem ceeb uas hemophilia A cuam tshuam yog pob qij txha, cov leeg, lub hlwb, thiab lub plab zom mov. Cov leeg nqaij thiab pob qij txha thiab cov hlab ntsha thiab plab hnyuv hemorrhages yog cov cim qhia ntawm hemophilia A. Lwm cov tsos mob ntawm hemophilia A yog cov ntshav txhaws tsis txaus ntawm kev raug mob hnyav lossis me me; Nyob rau hauv ib qho xwm txheej hnyav, nws tuaj yeem ua rau mob ntshav tsis txaus.
Daim duab 01: X- txuas Kev Sib Txuas Zoo
Kev kuaj mob hemophilia A yog tsim los ntawm kev soj ntsuam coagulation. Feem ntau cov kev kho mob rau hemophilia muaj xws li hloov qhov ploj lossis tsis muaj protein ntau VIII. Yog li ntawd, cov tshuaj tseem ceeb yog cov concentrated yam VIII hu ua clotting factor. Muaj ob hom ntawm qhov no: plasma-derived thiab recombinant. Thiab, cov kev kho mob zoo li no tau txhaj rau hauv cov leeg.
Hemophilia B yog dab tsi?
Hemophilia B yog ib hom kab mob los ntshav tshwm sim vim tsis muaj cov ntshav txhaws IX. Tsis muaj qhov xwm txheej IX yog qhov tsawg dua li lwm yam, thiab yog li ntawd, hemophilia B yog qhov tsis tshua muaj tshwm sim. Cov tsos mob ntawm hemophilia B muaj xws li nqaij tawv yooj yim, urinary tract los ntshav hu ua hematuria, qhov ntswg los ntshav hu ua epistaxis, thiab los ntshav hauv cov pob qij txha hu ua hemarthrosis. Cov neeg mob cuam tshuam nrog hemophilia B qhia cov kab mob ntau dua nrog rau qhov tsis muaj kev tu cev thiab kev kho mob.
Daim duab 02: Kev kuaj mob Hemophilia
Cov tsos mob tseem ceeb tshaj plaws ntawm hemophilia B yog gingival los ntshav thaum lub sij hawm tawg ntawm thawj cov hniav lossis cov hniav rho tawm. Hemophilia B mob hnyav ua rau cov ntshav tawm ntawm qhov ncauj, daim di ncauj, thiab gingiva. Factor IX deficiency ua rau muaj qhov tshwm sim tsis zoo los yog mob me me yog tias tsis kho tam sim ntawd. Kev kuaj mob rau hemophilia B yog ua los ntawm kev kuaj ntshav coagulation, kuaj ntshav coagulation, thiab cov qhab nia los ntshav. Kev kho mob hemophilia B suav nrog kev txhaj tshuaj ntawm cov tshuaj IX thiab ntshav.
Hemophilia C yog dab tsi?
Hemophilia C, uas tseem hu ua plasma thromboplastin antecedent deficiency, yog hom mob hemophilia vim qhov tsis txaus ntawm cov ntshav txhaws XI. Hemophilia C yog ib qho autosomal recessive qub txeeg qub teg txij li cov noob nyob rau ntawm chromosome 4. Hemophilia C yog qee zaum pom hauv cov tib neeg uas muaj kab mob lupus erythematosus. Cov tib neeg cuam tshuam nrog hemophilia C tsis tuaj yeem los ntshav. Yog li, cov teeb meem xws li hemorrhages feem ntau yuav tshwm sim tom qab kev phais lossis raug mob hnyav. Txawm li cas los xij, cov tsos mob ntawm hemophilia C muaj xws li los ntshav ntawm qhov ncauj, los ntshav qhov ntswg, ntshav nrog zis, ntshav tom qab yug menyuam, thiab los ntshav ntawm tonsils.
Kev kuaj mob hemophilia C yog nyob ntawm kev ua haujlwm ntev ib nrab ntawm thromboplastin lub sijhawm kawm. Nws yog ib qho kev kuaj ntshav uas qhia txog cov ntshav coagulation nrog lub sijhawm. Kev kho mob hemophilia C yog tshuaj tranexamic acid thaum lub sij hawm los yog tom qab qhov xwm txheej los ntshav. Cov plasma tshiab khov los yog qhov sib xyaw ua ke XI tau txhaj rau hauv qhov xwm txheej loj.
Dab tsi zoo sib xws ntawm Hemophilia A thiab B thiab C?
- Hemophilia A, B, thiab C cuam tshuam nrog qhov tsis txaus ntawm cov ntshav txhaws.
- Lawv yog genetic disorders.
- Ntxiv mus, tag nrho peb hom yog lub luag haujlwm rau kev mob ntshav siab.
- Cov txheej txheem Molecular xws li PCR tuaj yeem siv los kuaj xyuas tag nrho peb yam xwm txheej.
Qhov txawv ntawm Hemophilia A thiab B thiab C yog dab tsi?
Hemophilia A, B, thiab C yog cov kab mob los ntshav vim tsis muaj ntshav txhaws yam VIII, IX, thiab XI, feem. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm hemophilia A thiab B thiab C. Tsis tas li ntawd, hemophilia A thiab B feem ntau pom hauv cov txiv neej, thaum hemophilia C cuam tshuam rau ob leeg poj niam txiv neej sib npaug. Ntxiv mus, hemophilia A thiab B yog X-txuas recessive, thaum hemophilia C yog autosomal recessive.
Cov duab hauv qab no nthuav tawm qhov sib txawv ntawm hemophilia A thiab B thiab C hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Hemophilia A vs B vs C
Hemophilia A yog ib hom kab mob los ntshav uas tshwm sim los ntawm qhov tsis muaj ntshav txhaws VIII. Hemophilia B yog ib hom kab mob los ntshav uas tshwm sim los ntawm qhov tsis muaj ntshav txhaws IX. Hemophilia C, uas tseem hu ua plasma thromboplastin antecedent deficiency, yog ib hom mob me me ntawm hemophilia vim qhov tsis txaus ntawm cov ntshav txhaws XI. Hemophilia A thiab B yog vim muaj kev sib txuas ntawm X-txuas rov qab zoo nrog cov noob tsis zoo nyob ntawm X chromosome. Hauv qhov sib piv, hemophilia C yog txuam nrog qhov tsis xws ntawm cov noob ntawm chromosome. Yog li, qhov no qhia txog qhov sib txawv ntawm hemophilia A thiab B thiab C.
