Qhov sib txawv tseem ceeb ntawm streptokinase thiab tPA yog tias streptokinase yog cov kab mob cov kab mob siv los ua cov tshuaj thrombolytic thaum tPA (cov ntaub so ntswg plasminogen activator) yog cov protein sib xyaw mammalian siv los ua cov tshuaj thrombolytic.
Thrombolysis yog txheej txheem uas ua rau cov ntshav txhaws hauv cov hlab ntsha. Nws tseem hu ua fibrinolytic therapy. Cov tshuaj thrombolytic yog cov tshuaj siv rau thrombolysis. ST-elevation myocardial infarction, mob stroke, pulmonary embolism loj heev, cov hlab ntsha sib sib zog nqus thrombosis, mob limb ischemia, thiab clotted hemothorax yog ntau hom kab mob uas xav tau thrombolysis. Cov tshuaj thrombolytic yog biologics. Lawv tuaj yeem tsim los ntawm hom Streptococcus lossis los ntawm kev siv biotechnology recombinant. Streptokinase thiab tPA yog ob hom tshuaj thrombolytic.
Y Streptokinase yog dab tsi?
Streptokinase yog tshuaj thrombolytic. Nws yog ib hom kab mob uas tau muab los ntawm hom Streptococcus thiab tau tshawb pom hauv xyoo 1933 los ntawm beta-hemolytic streptococci. Raws li kev siv tshuaj, nws muaj txiaj ntsig zoo hauv kev ua kom cov ntshav txhaws tsim nyob rau hauv cov xwm txheej ntawm myocardial infarction, pulmonary embolism, thiab arterial thromboembolism. Nws muaj raws li kev txhaj tshuaj thiab tuaj yeem txhaj rau hauv cov leeg.
Daim duab 01: Streptococcus
Streptokinase yog fibrinolytic. Cov complexes ntawm streptokinase, ua ke nrog tib neeg plasminogen, muaj peev xwm hydrolytically qhib plasminogen unbound los ntawm activating daim ntawv cog lus cleavage los tsim plasmin. Muaj peb lub npe (α, β, γ) hauv streptokinase uas tuaj yeem khi nrog plasminogen. Cov tshuaj plasmin ua rau cov fibrin, uas yog qhov tseem ceeb ntawm cov ntshav thrombi (cov ntshav txhaws). Kev noj tshuaj ntau dhau ntawm streptokinase tuaj yeem kho nrog aminocaproic acid. Cov kev mob tshwm sim ntawm cov tshuaj no muaj xws li xeev siab, los ntshav, ntshav siab, thiab ua xua. Kev siv zaum ob hauv tib neeg lub neej feem ntau tsis pom zoo. Tsis muaj teeb meem nrog kev siv cov tshuaj no thaum cev xeeb tub. Tsis tas li ntawd, nws tseem nyob rau hauv cov npe tshuaj tseem ceeb hauv World He alth Organization. Txawm li cas los xij, streptokinase tsis muaj muag hauv Tebchaws Meskas lawm.
TPA yog dab tsi?
Tissue plasminogen activator (tPA) yog ib qho kev sib txuas ntawm cov tsiaj nyeg protein uas tsim los siv los ua cov tshuaj thrombolytic. Nws yog ib qho protein uas koom nrog hauv kev ua kom cov ntshav txhaws. tPA yog ib qho serine protease feem ntau pom ntawm cov hlwb endothelial. Cov hlwb endothelial yog cov hlwb uas ua rau cov hlab ntsha.tPA yog ib qho enzyme uas catalyzes hloov pauv ntawm plasminogen rau plasmin. Tib neeg tPA muaj qhov hnyav molecular ntawm 70 kDa kwv yees li. Cov ntaub so ntswg plasminogen activator yog encoded los ntawm PLAT noob nyob rau ntawm chromosome 8.
Daim duab 02: tPA
Raws li cov tshuaj thrombolytic, tPA tuaj yeem tsim tau siv cov txheej txheem biotechnology recombinant. tPA ua los ntawm cov cuab yeej siv thev naus laus zis hu ua recombinant cov ntaub so ntswg plasminogen activator (rtPA). rtPA yog thawj zaug tsim los ntawm recombinant DNA cov tswv yim ntawm Genentech hauv 1982. Alteplase, reteplase, thiab tenecteplase yog ntau lub npe ntawm recombinant tPA tam sim no muag. Lawv muaj txiaj ntsig zoo hauv cov tshuaj kho mob los kho embolic lossis thrombotic stroke. Cov kev mob tshwm sim ntawm rtPA muaj xws li xeev siab, ntuav, ntshav siab, kiv taub hau, kub taub hau, thiab ua xua.
Dab tsi yog qhov zoo sib xws ntawm Streptokinase thiab tPA?
- Streptokinase thiab tPA yog ob yam tshuaj thrombolytic.
- YLawv yog cov proteins enzymatic.
- Ob cov tshuaj hloov plasminogen rau plasmin, yog li rhuav tshem fibrin hauv cov ntshav thrombi.
- Cov tshuaj no yog siv rau hauv cov mob myocardial infarction, pulmonary embolism, thiab stroke.
- Ob yam tshuaj muaj nyob rau hauv cov npe tshuaj tseem ceeb hauv World He alth Organization.
- Kev noj ntau dhau ntawm ob cov tshuaj tuaj yeem kho nrog aminocaproic acid.
Qhov txawv ntawm Streptokinase thiab tPA yog dab tsi?
Streptokinase yog cov kab mob cov kab mob siv los ua cov tshuaj thrombolytic, thaum tPA yog cov protein sib xyaw ua ke uas siv los ua cov tshuaj thrombolytic. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm streptokinase thiab tPA. Tsis tas li ntawd, qhov hnyav molecular ntawm streptokinase yog kwv yees li 47 kDa, thaum qhov hnyav molecular ntawm tPA yog kwv yees li 70 kDa.
Cov hauv qab no qhia txog qhov sib txawv ntawm streptokinase thiab tPA hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Streptokinase vs tPA
Streptokinase thiab tPA yog ob yam tshuaj thrombolytic. Streptokinase yog ib hom kab mob uas tau los ntawm cov kab mob Streptococcus. Ntawm qhov tod tes, tPA (cov ntaub so ntswg plasminogen activator) yog ib qho kev sib txuas ntawm cov tsiaj nyeg protein. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm streptokinase thiab tPA.
