Qhov sib txawv tseem ceeb ntawm streptokinase thiab urokinase yog tias streptokinase yog tus neeg saib xyuas fibrinolytic uas cais los ntawm beta haemolytic Streptococcus kab mob, thaum urokinase yog tus neeg saib xyuas fibrinolytic uas cais los ntawm tib neeg cov zis.
Cov txheej txheem thrombosis tshwm sim thaum cov ntshav txhaws thaiv cov hlab ntsha thiab cov hlab ntsha. Cov tsos mob ntawm tus mob no muaj xws li mob thiab o ntawm ib ceg, mob hauv siab, thiab loog ntawm ib sab ntawm lub cev. Cov teeb meem uas cuam tshuam nrog thrombosis muaj xws li kev ua phem rau lub neej xws li mob stroke lossis plawv nres. Fibrinolytic agents yog cov tshuaj uas tiv thaiv cov hlab ntsha los ntawm kev rhuav tshem cov thrombus. Streptokinase thiab urokinase yog ob hom fibrinolytic agents.
Streptokinase yog dab tsi?
Streptokinase yog cov kab mob protein uas muaj qhov hnyav molecular ntawm 47000 Da. Nws feem ntau yog cais los ntawm beta haemolytic Streptococcus ntawm Lancefield pawg c. Nws yog ib hom kab mob fibrinolytic siv los rhuav tshem cov thrombus. Nws yog cov tshuaj thrombolytic uas yog siv los rhuav tshem cov hlab ntsha hauv cov neeg mob uas muaj kev phom sij rau lub neej xws li myocardial infarction, pulmonary embolism, thiab arterial thromboembolism. Feem ntau, cov tshuaj no yog muab los ntawm cov hlab ntsha raws li kev txhaj tshuaj. Streptokinase tsis yog ib qho enzyme, thiab nws txoj haujlwm ntawm plasminogen tsis ncaj qha. Cov kab mob no tuaj yeem tsim cov stoichiometric complex nrog plasminogen, thiab cov complex no activates plasminogen rau plasmin hloov dua siab tshiab.
Streptokinase complex nrog tib neeg plasminogen tuaj yeem ua kom hydrolytically qhib lwm cov plasminogen uas tsis muaj kev cuam tshuam los ntawm kev ua kom dhau los ntawm daim ntawv cog lus cleavage los tsim cov plasmin. Ntxiv mus, muaj peb lub npe hauv streptokinase hu ua α, β, thiab γ. Cov npe no sib sau ua ke nrog plasminogen thiab qhib nws. Tom qab ntawd, plasmin rhuav tshem fibrin, qhov tseem ceeb ntawm cov ntshav txhaws, yog li ua kom cov ntshav txhaws. Streptokinase tau pom thawj zaug hauv xyoo 1933 los ntawm beta haemolytic Streptococcus. Cov kev mob tshwm sim ntawm cov tshuaj no muaj xws li xeev siab, los ntshav, ntshav siab, thiab ua xua. Kev siv tshuaj thib ob yog tsis pom zoo. Tsis tas li ntawd, tsis muaj teeb meem nrog kev siv thaum cev xeeb tub. Nws kuj tseem nyob hauv World He alth Organization cov npe ntawm cov tshuaj tseem ceeb. Txawm li cas los xij, nws tsis muaj muag hauv Tebchaws Meskas lawm.
YUrokinase yog dab tsi?
Urokinase yog tus neeg ua haujlwm fibrinolytic uas cais tawm ntawm tib neeg cov zis. Nws tseem hu ua urokinase plasminogen activator. Qhov no yog ib qho serine protease. Nws tau pom nyob rau xyoo 1947 los ntawm McFarlane thiab Pilling. Qhov no enzyme kuj pom nyob rau hauv cov ntshav thiab extracellular matrix ntawm ntau cov ntaub so ntswg. PLAU yog cov noob coding no serine protease.
Daim duab 01: Urokinase
Urokinase ncaj qha hloov plasminogen rau plasmin los ntawm qhov tshwj xeeb cleavage ntawm arginine-valine daim ntawv cog lus hauv plasminogen. Tsis tas li ntawd, nce qib ntawm urokinase thiab lwm yam khoom ntawm plasminogen activation system tau pom tias muaj feem cuam tshuam nrog cov qog nqaij hlav. Yog li, nws ntseeg tau tias qhov kev puas tsuaj ntawm cov ntaub so ntswg tom qab plasminogen ua kom yooj yim rau cov ntaub so ntswg ntxeem tau, uas ua rau cov qog metastasis. Ntxiv mus, nws yog ncaj qha mus rau qhov chaw ntawm lub clot. Cov kev mob tshwm sim ntawm cov tshuaj no muaj xws li cov pos hniav los ntshav, hnoos ntshav, mob taub hau, mob qhov ntswg, ua pa nyuaj, tuag tes tuag taw, los ntshav ntawm qhov chaw mos, cov cuab yeej liab, cov zis xim av tsaus, lub plawv dhia ceev, khaus tawv nqaij, hawb pob, thiab lwm yam.
Dab tsi zoo sib xws ntawm Streptokinase thiab Urokinase?
- Streptokinase thiab urokinase yog ob hom kab mob fibrinolytic.
- Ob leeg yog cov proteins ua los ntawm cov amino acids.
- Cov tshuaj no zom cov fibrin hauv lub thrombus.
- Ob yam tshuaj muaj kev phiv.
- Lawv tuaj yeem siv tau rau cov teeb meem loj xws li mob stroke lossis lub plawv nres vim thrombosis.
Qhov txawv ntawm Streptokinase thiab Urokinase yog dab tsi?
Streptokinase yog tus neeg saib xyuas fibrinolytic cais los ntawm beta haemolytic Streptococcus kab mob, thaum urokinase yog tus neeg saib xyuas fibrinolytic cais tawm ntawm tib neeg cov zis. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm streptokinase thiab urokinase. Tsis tas li ntawd, streptokinase yog cov kab mob protein, thaum urokinase yog tib neeg serine protease enzyme.
Cov hauv qab no qhia txog qhov sib txawv ntawm streptokinase thiab urokinase hauv daim ntawv qhia rau ib sab ntawm kev sib piv.
Summary – Streptokinase vs Urokinase
Streptokinase thiab urokinase yog ob hom kab mob fibrinolytic siv hauv kev kho thrombolytic. Streptokinase yog cov kab mob protein cais tawm los ntawm beta haemolytic Streptococcus kab mob, thaum urokinase yog ib qho serine protease enzyme cais los ntawm tib neeg cov zis. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm streptokinase thiab urokinase.
