Qhov sib txawv tseem ceeb ntawm methyl B12 thiab B12 yog tias methyl B12 muaj adenosyl ligand nyob rau hauv cov vitamin B12 qauv hloov los ntawm ib pawg methyl functional, whereas B12 los yog vitamin B12 muaj ib tug adenosyl functional pab pawg neeg txuas mus rau lub chaw hlau.
Lo lus B12 sawv cev rau vitamin B12. Txawm li cas los xij, methyl B12 yog ib qho derivative ntawm vitamin B12, uas muaj ib pawg methyl ntawm qhov chaw ntawm pawg adenosyl ntawm cov vitamin B12 molecule.
Methyl B12 yog dab tsi?
Methyl B12 lossis methylcobalamin yog hom cobalamin. Cobalamin yog lwm lub npe rau vitamin B12. Cov tshuaj no txawv ntawm cyanocobalamin nyob rau hauv txoj kev uas cyano pawg cob alt hloov nrog ib pawg methyl. Cov qauv tshuaj methylcobalamin muaj octahedral cob alt (II) metallic chaw. Cov khoom no zoo li ci liab-xim crystals. Raws li kev sib koom tes chemistry, cov khoom no yog ib qho tsis tshua muaj cov khoom sib xyaw uas muaj cov hlau-alkyl bonds.
Daim duab 01: Cov Qauv Tshuaj ntawm Methyl B12
Physiologically, methyl B12 yog sib npaug rau vitamin B12. Peb tuaj yeem siv los tiv thaiv lossis kho cov mob uas tshwm sim los ntawm qhov tsis muaj vitamin B12 kom tsawg - vitamin B12 tsis txaus. Ntxiv mus, cov khoom no muaj txiaj ntsig zoo hauv kev kho mob peripheral neuropathy, ntshav qab zib neuropathy, thiab amyotrophic lateral sclerosis.
Lub npe lag luam ntawm methyl B12 yog Cobalamin. Txoj hauv kev tseem ceeb ntawm kev tswj hwm cov tshuaj no suav nrog kev tswj hwm qhov ncauj, sublingual, thiab txhaj tshuaj. Yog tias nws tau noj, ces nws tsis yog siv ncaj qha li cofactor. Ua ntej, nws hloov mus rau hauv cob (II) alamin los ntawm MMACHC. Tom qab ntawd, nws tau hloov dua siab tshiab rau hauv ob hom ntawv hu ua adenosylcobalamin thiab methylcobalamin.
Peb tuaj yeem tsim methylcobalamin hauv chav kuaj los ntawm kev txo cov cyanocobalamin nrog rau sodium borohydride nyob rau hauv muaj cov tshuaj alkaline. Cov tshuaj tiv thaiv no yuav tsum tau ua raws li kev ntxiv ntawm methyl iodide.
Methyl B12 tuaj yeem koom nrog Wood-Ljungdahl txoj hauv kev uas yog qhov tseem ceeb rau qee cov kab mob siv cov pa roj carbon dioxide los ua qhov chaw ntawm cov organic tebchaw. Hauv cov txheej txheem no, pawg methyl hauv methyl B12 khub niam txiv nrog carbon monoxide.
B12 yog dab tsi?
B12 lossis cobalamin yog cov vitamin dej-soluble uas koom nrog hauv cov metabolism. Nws yog ib qho tseem ceeb raws li cofactor hauv DNA synthesis thiab hauv ob qho tib si fatty acid thiab amino acid metabolism. Ntxiv mus, cov tshuaj no muaj lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm lub paj hlwb los ntawm nws lub luag haujlwm hauv kev sib txuas ntawm myelin. Tsis tas li ntawd, nws muaj lub luag haujlwm hauv kev loj hlob ntawm cov qe ntshav liab hauv cov pob txha.
Vitamin B12 deficiency tuaj yeem tshwm sim hauv cov tebchaws tsim kho vim kev nqus tsis zoo uas yog tshwm sim los ntawm kev poob ntawm lub plab zom mov. Qhov tseem ceeb no yuav tsum tau khi rau ib qho khoom noj uas muaj vitamin B12 rau kev nqus tau. Lwm qhov laj thawj tseem ceeb ntawm cov vitamin B12 tsis txaus yog qhov muaj hnub nyoog txog kev poob qis hauv plab acid. Qhov no yog vim tias muaj kua qaub tuaj yeem tso cov protein-bound vitamins.
Daim duab 02: Tus Qauv ntawm Vitamin B12
Thaum xav txog kev siv tshuaj kho mob ntawm cov tshuaj vitamin B12, nws yog ib qho tseem ceeb hauv kev ua kom tsis txaus thiab kho cov tshuaj lom cyanide. Peb tuaj yeem kho ntau qhov vitamin B12 tsis txaus siv cov tshuaj intramuscular ntau zaus ntawm cov tshuaj vitamin. Qhov no yuav tsum tau ua raws li kev saib xyuas ntawm cov koob tshuaj txhaj tshuaj lossis kev txhaj tshuaj ntawm qhov ncauj ntawm lub sijhawm ntev. Thaum lub sij hawm cyanide lom, peb tuaj yeem siv ntau ntau ntawm hydroxocobalamin intravenously, feem ntau ua ke nrog sodium thiosulfate. Tom qab ntawd cov tshuaj lom cyanide ion tshem tawm cov hydroxycobalamin hydroxide ligand, uas ua rau tsim cov cyanocobalamin uas tsis muaj tshuaj lom uas tuaj yeem tawm los ntawm cov zis.
Qhov txawv ntawm Methyl B12 thiab B12 yog dab tsi?
Lo lus B12 sawv cev rau vitamin B12. Txawm li cas los xij, methyl B12 yog ib qho derivative ntawm vitamin B12, uas muaj ib pawg methyl ntawm qhov chaw ntawm pawg adenosyl ntawm cov vitamin B12 molecule. Qhov sib txawv tseem ceeb ntawm methyl B12 thiab B12 yog tias methyl B12 muaj cov adenosyl ligand nyob rau hauv cov vitamin B12 qauv hloov los ntawm ib pawg methyl functional, whereas B12 los yog vitamin B12 muaj ib tug adenosyl functional pab pawg neeg txuas mus rau lub chaw hlau.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm methyl B12 thiab B12 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Methyl B12 vs B12
Methyl B12 lossis methylcobalamin yog hom cobalamin. B12 los yog cobalamin yog dej-soluble vitamin uas koom nrog hauv metabolism. Qhov sib txawv tseem ceeb ntawm methyl B12 thiab B12 yog tias methyl B12 muaj cov adenosyl ligand nyob rau hauv cov vitamin B12 qauv hloov los ntawm ib pawg methyl functional, whereas B12 los yog vitamin B12 muaj ib tug adenosyl functional pab pawg neeg txuas mus rau lub chaw hlau.
