Qhov sib txawv tseem ceeb ntawm kev hloov pauv hloov pauv thiab hloov pauv hloov pauv yog qhov hloov pauv hloov pauv yog qhov ntxig lossis tshem tawm ntawm lub hauv paus khub lossis lub hauv paus khub los ntawm DNA ib ntu ntawm cov noob uas ua rau muaj kev hloov pauv hauv cov lus qhib qhib thaum hloov pauv hloov pauv. yog pauv ntawm ib nucleotide los ntawm lwm nucleotide nyob rau hauv ib tug DNA sequence.
Cov kev hloov pauv uas tshwm sim hauv DNA kab ke tuaj yeem ua rau ntau hom kev hloov pauv. Raws li qhov tshwm sim ntawm kev hloov pauv, ib qho kab ke ntawm cov noob tuaj yeem hloov pauv thiab ua rau muaj kev cuam tshuam ntau yam xws li qog nqaij hlav, kab mob caj ces, kev yug me nyuam, teeb meem infertility, thiab lwm yam. Muaj ntau yam cuam tshuam rau kev hloov pauv. UV thiab tshuaj lom neeg yog qhov tseem ceeb ntawm lawv.
Dab tsi yog Frameshift Mutation?
A frameshift mutation is a type of mutation that happens because of insertion or deletion of a base pair or base pairs. Nws hloov pauv cov kab ntawv nyeem ntawm cov noob thiab qhia txog cov protein tsis tiav lossis tsis raug. Feem ntau, nucleotide triplets ua codons. Txhua codon codes rau cov amino acid tshwj xeeb. Thaum nkag los yog tshem tawm, nucleotides hauv triplets hloov thiab qhia qhov sib txawv piv rau cov thawj theem. Tsis ncaj ncees lawm codon ib ntus ua rau cov amino acid tsis raug thaum lub sijhawm txhais lus. Thaum kawg, nws tsim cov amino acid sib txawv. Hauv lwm lo lus, frameshift mutation tsim cov protein tsis raug thaum kawg ntawm cov noob qhia.
Daim duab 01: Frameshift Mutation
Frameshift kev hloov pauv ua rau muaj ntau yam teeb meem xws li Tay-Sachs kab mob, Crohn tus kab mob, Cystic fibrosis, HIV thiab mob qog noj ntshav. Frameshift mutation tuaj yeem tshwm sim. Nws kuj tuaj yeem tshwm sim los ntawm kev tawm tsam sab nraud xws li tshuaj lom neeg.
Kev Hloov Pauv Hloov Pauv yog dab tsi?
Kev hloov pauv hloov pauv yog qhov hloov pauv ntawm DNA ib ntus vim kev sib pauv ntawm nucleotide nrog lwm nucleotide. Ib lub hauv paus pauv nrog lwm tus, yog li, nws yog hom kev hloov pauv ntawm qhov taw tes. Qee qhov kev hloov pauv ib puag ncig yog kev hloov pauv ntsiag to. Txawm li cas los xij, qee qhov ua rau muaj kab mob. Piv txwv li, ib qho kev hloov pauv hauv beta hemoglobin noob ua rau muaj kev phom sij rau lub neej; Piv txwv li, sickle cell anemia vim kev hloov pauv ntawm ib qho amino acid. Tsis tas li ntawd, kev hloov pauv hauv paus tsim cov proteins tsis tiav uas tsis ua haujlwm.
Daim duab 02: Kev Hloov Pauv Hloov Pauv
Cov tshuaj tua kab mob ua rau muaj kev hloov pauv hauv paus. Ntxiv mus, UV teeb kuj tuaj yeem ua rau tib lub hauv paus hloov pauv.
Dab tsi yog qhov zoo sib xws ntawm Frameshift Mutation thiab Base Hloov Hloov Hloov?
- Frameshift mutation thiab base hloov pauv yog ob hom kev hloov pauv tshwm sim hauv DNA sequence.
- Lawv hloov cov caj ces ntawm lub cev.
- Ntxiv mus, lawv tuaj yeem ua rau tsis xav tau lossis ua haujlwm tsis zoo.
- Ob leeg yog tshwm sim los ntawm cov tshuaj lom neeg, hluav taws xob, UV, thiab lwm yam.
Dab tsi yog qhov txawv ntawm Frameshift Mutation thiab Base Hloov Hloov Hloov?
Insertions thiab deletions ua rau frameshift mutations, thaum sib pauv ntawm ib lub hauv paus los ntawm lwm tus (hloov pauv) ua rau lub hauv paus hloov pauv. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm kev hloov pauv hloov pauv thiab hloov pauv hloov pauv.
Hauv qab infographic qhia txog qhov sib txawv ntawm qhov hloov pauv hloov pauv thiab hloov pauv hloov pauv.
Summary – Frameshift Mutation vs Base Change Mutation
Frameshift mutation ua rau muaj kev hloov pauv hauv kev nyeem ntawv ntawm cov noob, uas ua rau kev qhia ntawm cov protein tsis raug. Ntxig thiab tshem tawm yog qhov laj thawj tseem ceeb rau kev hloov pauv hloov pauv. Base substation mutation ua rau muaj kev hloov pauv hauv DNA ib ntus vim kev sib pauv ntawm ib lub hauv paus los ntawm lwm tus. Lawv kuj tsim cov proteins tsis raug thaum kawg yog tias kev hloov pauv tsis nyob twj ywm. Yog li, qhov no qhia txog qhov sib txawv ntawm qhov hloov pauv hloov pauv thiab hloov pauv hloov pauv.
