Qhov sib txawv tseem ceeb ntawm COX 1 thiab COX 2 inhibitors yog COX 1 inhibitor yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj uas inhibits cyclooxygenase-1 enzyme tau qhia nyob rau hauv feem ntau cov ntaub so ntswg thaum COX 2 inhibitor yog non-steroidal tshuaj tiv thaiv. - tshuaj inflammatory uas inhibits cyclooxygenase-2 enzyme qhia nyob rau hauv cov cheeb tsam ntawm o.
Non-steroidal anti-inflammatory tshuaj (NSAIDS) feem ntau muab tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tua kab mob. Lawv yog siv nyob rau hauv kev kho mob ntawm ntau yam kab mob. Cov tshuaj uas tsis yog-steroidal anti-inflammatory siv tshuaj inhibit ib qho kev txwv cov enzyme hu ua cyclooxygenase (COX) koom nrog hauv kev tsim cov prostaglandins. Ob lub isoforms ntawm cov enzyme no tau txheeb xyuas: COX 1 thiab COX 2. COX 1 inhibitor thiab COX 2 inhibitor yog ob hom tshuaj tiv thaiv kab mob uas tsis yog tshuaj steroidal koom nrog inhibition ntawm cyclooxygenase 1 (COX 1) thiab cyclooxygenase 2 (COX 2), raws.
COX 1 Inhibitors yog dab tsi?
COX 1 inhibitor yog cov tshuaj uas tsis yog-steroidal los tiv thaiv kab mob uas inhibits cyclooxygenase-1 enzyme. Qhov no enzyme yog constitutively qhia nyob rau hauv feem ntau cov ntaub so ntswg. Cyclooxygenase-1 (COX 1) isoform nquag tsim cytoprotective prostaglandins. Cov enzyme no muaj nyob rau hauv cov ntaub so ntswg, nrog rau lub plab hnyuv mucosa, ob lub raum, thiab platelets. Cyclooxygenase-1 isoform tswj cov txheej txheem ntawm lub plab thiab cov hnyuv. Qhov isoform no tseem tiv thaiv lub plab los ntawm cov kua txiv hmab txiv ntoo. Ntxiv mus, Cyclooxygenase-1 isoform koom nrog rau lub raum thiab platelet ua haujlwm. Cyclooxygenase-1 enzyme tsim prostaglandins uas ua rau mob, kub taub hau, thiab mob. Yog li, COX 1 inhibitor yog siv los inhibit cyclooxygenase-1 isoform. Txij li lub luag haujlwm tseem ceeb ntawm cyclooxygenase-1 yog los tiv thaiv lub plab thiab txoj hnyuv thiab ua rau cov ntshav txhaws, kev siv cov tshuaj COX 1 inhibitor tuaj yeem ua rau tsis muaj kev phiv.
Daim duab 01: COX 1 Inhibitor
Tseem tshuaj tsis-steroidal tshuaj tiv thaiv kab mob xws li ibuprofen, aspirin, thiab naproxen yog inhibitors ntawm COX 1 thiab COX 2 isoforms vim lawv tsis xaiv hauv lawv qhov kev ua. Cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj yog siv los kho cov mob xws li mob caj dab. Niaj hnub nimno xaiv COX 1 inhibitors xaiv tsuas yog inhibit COX 1 isoform. Qee qhov piv txwv ntawm niaj hnub xaiv COX 1 inhibitors suav nrog ketorolac, flurbiprofen, ketoprofen, indomethacin, tolmetin, piroxicam, thiab meclofenamate. Txawm li cas los xij, qhov inhibition ntawm COX 1 isoform tuaj yeem ua rau muaj kev phiv xws li mob plab hnyuv thiab tsis tswj los ntshav.
COX 2 Inhibitors yog dab tsi?
COX 2 inhibitor yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj uas inhibits cyclooxygenase-2 enzyme uas tau nthuav tawm hauv thaj chaw mob. Cov tshuaj Selective COX 2 inhibitor muaj cov kab mob loj heev uas loj dhau mus rau kev taw qhia mus rau hauv qhov chaw khi ntawm cyclooxygenase-1 enzyme. Tab sis lawv tau ua kom haum thiab khi rau cyclooxygenase-2 isoform. Cyclooxygenase-2 enzyme plays lub luag haujlwm tseem ceeb hauv kev tswj hwm vascular.
Daim duab 02: COX 2 Inhibitor
Qhov inhibition ntawm cyclooxygenase-2 isoform ua rau txo qis ntawm vasodilator prostaglandins los ntawm cov hlwb endothelial. Txawm li cas los xij, thromboxane los ntawm platelets tsis cuam tshuam los ntawm COX inhibitor vim tsis muaj COX 2 isoform tam sim no ntawm cov platelets paub tab. Tsis tas li ntawd, COX inhibitor tau xav tias yog qhov ua rau muaj kev pheej hmoo ntawm kev tsim myocardial infarction, congestive plawv tsis ua hauj lwm, mob stroke, pulmonary thiab systemic hypertension. Qee qhov piv txwv suav nrog COX 2 inhibitors yog sulindac, diclofenac, celecoxib, meloxicam, etodolac, etoricoxib, thiab lumiracoxib.
Qhov Zoo sib xws ntawm COX 1 thiab COX 2 Inhibitors yog dab tsi?
- COX 1 inhibitor thiab COX 2 inhibitor yog ob yam tshuaj uas tsis yog tshuaj steroidal.
- Lawv koom nrog inhibition ntawm cyclooxygenase 1 (COX 1) thiab cyclooxygenase 2 (COX 2) enzymes uas tsim cov prostaglandins.
- Ob leeg COX 1 thiab COX 2 inhibitors tuaj yeem ua rau muaj kev phiv loj heev.
- COX 1 thiab COX 2 inhibitors yog xaiv hauv kev ua dua li cov tshuaj uas tsis yog tshuaj steroidal los tiv thaiv kab mob.
Qhov txawv ntawm COX 1 thiab COX 2 Inhibitors yog dab tsi?
COX 1 inhibitor yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj uas inhibits cyclooxygenase-1 enzyme, uas yog constitutively qhia nyob rau hauv feem ntau cov ntaub so ntswg, thaum COX 2 inhibitor yog ib tug non-steroidal anti-inflammatory tshuaj uas inhibits cyclooxygenase. -2 enzyme, uas yog qhia nyob rau hauv cov cheeb tsam ntawm o. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm COX 1 thiab COX 2 inhibitors. Tsis tas li ntawd, cov kev mob tshwm sim ntawm COX 1 inhibitor suav nrog cov kab mob hauv plab hnyuv thiab cov ntshav tsis tswj tau, thaum cov kev mob tshwm sim ntawm COX 2 inhibitor suav nrog kev txhim kho myocardial infarction, congestive heart failure, stroke, pulmonary and systemic hypertension.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm COX 1 thiab COX 2 inhibitors hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – COX 1 vs COX 2 Inhibitors
COX 1 inhibitor thiab COX 2 inhibitor yog ob yam tshuaj uas tsis yog tshuaj steroidal. Lawv xaiv ntau dua li cov tshuaj uas tsis yog tshuaj steroidal los tiv thaiv kab mob xws li ibuprofen, aspirin, thiab naproxen. COX 1 inhibitor yog ib yam tshuaj uas inhibits cyclooxygenase-1 enzyme. COX 2 inhibitor yog cov tshuaj uas inhibits cyclooxygenase-2. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm COX 1 inhibitor thiab COX 2 inhibitor.
