Qhov sib txawv tseem ceeb ntawm interferon thiab peginterferon yog tias interferon yog cov tshuaj tiv thaiv kab mob uas tsis yog tshuaj kho los ntawm kev khi rau polyetlylene glycol, thaum peginterferon yog cov tshuaj tiv thaiv kab mob uas tau hloov kho los ntawm kev khi rau polyetlylene glycol.
Thaum tus kab mob kis tus tswv tsev, nws nkag mus rau lub hlwb ntawm nws tus tswv kom muaj sia nyob thiab rov ua dua. Qhov no yuav pab tus kab mob kom luam tau ntau dua thiab pab kom lawv kis tus kab mob tau zoo heev. Tib neeg lub cev thiab lub cev tiv thaiv kab mob muaj ntau txoj hauv kev los tshem tawm tus kab mob. Ib txhia ntawm lawv yog cytotoxic T hlwb, interferon, thiab cov tshuaj tiv thaiv. Cytotoxic T cells tua cov kab mob kis kab mob los ntawm cov tshuaj lom neeg nruab nrab. Interferons tuaj yeem tiv thaiv tus kab mob rov ua dua tshiab, thiab lawv kuj ua raws li cov khoom siv hluav taws xob. Muaj ntau hom interferons, xws li tus qauv interferons thiab tshuaj peginterferons. Interferon thiab peginterferon yog ob hom tshuaj tiv thaiv kab mob uas tuaj yeem tiv thaiv kab mob.
Interferon yog dab tsi?
Interferon yog tus neeg sawv cev tiv thaiv kab mob uas hloov kho cov haujlwm ntawm lub cev tiv thaiv kab mob. Nws tsis yog tshuaj hloov kho los ntawm kev khi rau polyetlylene glycol (PEG). Nws yog tsim thiab tso tawm los ntawm cov cell hauv teb rau cov kab mob kis. Feem ntau, cov kab mob kis tau tus kab mob tuaj yeem tso tawm interferons uas ua rau cov hlwb nyob ze los txhim kho lawv cov tshuaj tiv thaiv kab mob. Interferon belongs rau ib pawg loj ntawm cov proteins hu ua cytokines. Lub luag haujlwm ntawm cov protein no yog sib txuas lus ntawm cov hlwb kom ua rau muaj kev tiv thaiv kev tiv thaiv. Qhov no yuav pab tshem tawm cov kab mob txawv teb chaws.
Daim duab 01: Interferon
Ib txwm, interferons kuj muaj peev xwm cuam tshuam nrog tus kab mob sib kis thiab tiv thaiv cov hlwb los ntawm kev kis tus kab mob. Ntxiv mus, interferon ua tiav ntau yam haujlwm. Nws activates lub cev tiv thaiv kab mob xws li ntuj killer hlwb thiab macrophages. Tsis tas li ntawd, nws nce kev tiv thaiv tus tswv los ntawm kev tswj hwm kev nthuav qhia antigen. Cov tsos mob xws li kub taub hau thiab mob leeg tuaj yeem tshwm sim vim kev tsim cov interferons thiab lwm yam cytokines. Muaj ntau tshaj nees nkaum qhov sib txawv interferon noob thiab cov proteins uas tau txheeb xyuas hauv cov tsiaj xws li tib neeg.
Peginterferon yog dab tsi?
Peginterferon yog ib qho tshuaj tiv thaiv kab mob uas tau hloov kho los ntawm kev khi rau polyetlylene glycol. Qhov no pegylated interferon feem ntau hu ua peginterferon. Nws yog ib qho tshuaj hloov kho interferon siv rau kev kho kab mob siab C thiab kab mob siab B (tsis tshua muaj). Los ntawm kev txuas PEG rau interferon, nws yuav nyob hauv lub cev (feem ntau hauv cov ntshav) ntev dua. Yog li, PEG prolongs ib nrab-lub neej ntawm peginterferon. Tsis yog txhaj tshuaj interferon peb zaug hauv ib lub lis piam, tsuas yog txhaj tshuaj peginterferon xwb. Qhov no pab cov neeg mob siab mob siab heev. Tam sim no muaj ob versions ntawm peginterferon nyob rau hauv kev ua lag luam. Lawv yog pegasys (peginterferon α-2a) thiab peginterferon α-2b). Ob qho tshuaj no muaj cov tshuaj pharmacokinetics zoo sib xws nrog qhov sib txawv me me xwb. Txawm hais tias peginterferon yog ib qho tshuaj zoo rau cov kab mob, nws yog kev kho mob kim.
Dab tsi yog qhov zoo sib xws ntawm Interferon thiab Peginterferon?
- Interferon thiab peginterferon yog ob hom tshuaj tiv thaiv kab mob uas tuaj yeem tiv thaiv kab mob.
- Cov molecules no yog cov proteins uas ua los ntawm cov amino acids.
- Ob leeg yog taw qhia cov molecules.
- Lawv tuaj yeem cuam tshuam nrog cov kab mob sib kis thiab tiv thaiv cov hlwb.
- Ob lub molecules yog siv los ua tshuaj tiv thaiv kab mob siab B thiab C.
Qhov txawv ntawm Interferon thiab Peginterferon yog dab tsi?
Interferon yog ib qho tshuaj tiv thaiv kab mob uas tsis muaj tshuaj lom neeg rau polyetlylene glycol thaum peginterferon yog cov tshuaj tiv thaiv kab mob uas tau hloov kho los ntawm kev khi rau polyetlylene glycol. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm interferon thiab peginterferon. Tsis tas li ntawd, interferon tsis zoo tiv thaiv kab mob siab B thiab C ntau dua li peginterferon. Ntawm qhov tod tes, peginterferon muaj txiaj ntsig zoo tiv thaiv kab mob siab B thiab C ntau dua li interferon.
Cov hauv qab no infographic teev qhov sib txawv ntawm interferon thiab peginterferon nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Interferon vs Peginterferon
Interferon thiab peginterferon yog ob hom tshuaj tiv thaiv kab mob. Lawv tuaj yeem tiv thaiv tus kab mob rov ua dua tshiab thiab tuaj yeem ua raws li cov cim qhia txog kev txhim kho kev tiv thaiv kab mob. Interferon tsis yog tshuaj hloov kho los ntawm kev khi rau polyetlylene glycol, thaum peginterferon yog tshuaj hloov kho los ntawm kev khi rau polyetlylene glycol. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm interferon thiab peginterferon.
