Qhov sib txawv tseem ceeb ntawm lactate thiab lactate dehydrogenase yog tias lactate yog daim ntawv deprotonated ntawm lactic acid, hos lactate dehydrogenase yog ib qho enzyme uas tseem ceeb hauv kev hloov lactate rau hauv pyruvate.
Lactic acid yog cov organic acidic compound uas muaj cov tshuaj formula CH3CH(OH)COOH. Peb tuaj yeem cais nws raws li cov khoom siv dawb uas yog miscible nrog dej. Cov tshuaj aqueous yog xim tsis muaj xim. Muaj cov khoom siv ntuj tsim ntawm lactic acid, thiab kev tsim khoom tuaj yeem ua tiav, thiab. Lub conjugate puag ntawm lactic acid yog lactate anion. Lactate hloov mus rau hauv pyruvate nyob rau hauv lub xub ntiag ntawm lactate dehydrogenase enzyme.
Lactate yog dab tsi?
Lactate yog anion thiab lub hauv paus conjugate ntawm lactic acid. Nws yog hydroxy monocarboxylic acid anion uas tsim los ntawm deprotonation ntawm pawg carboxy hauv lactic acid. Feem ntau, peb cov leeg nqaij, cov qe ntshav liab, lub hlwb, thiab lwm cov ntaub so ntswg tuaj yeem tsim cov anion thaum lub sij hawm anaerobic zog tsim. Hauv lwm lo lus, lactate yog cov khoom kawg ntawm cov metabolism hauv anaerobic, thiab nws tsim nyob rau hauv cov leeg pob txha, hlwb, erythrocytes, tawv nqaij thiab plab raws li cov khoom pov tseg los ntawm gluconeogenesis hauv daim siab thiab ua tiav oxidation. Yog li ntawd, lactate anion tuaj yeem pom nyob rau hauv qis hauv peb cov ntshav.
Daim duab 01: Cov Qauv Tshuaj ntawm Lactic Acid
Txawm li cas los xij, qhov nce ntxiv ntawm lactate anion lossis txo qhov kev tshem tawm ntawm cov anion tuaj yeem ua rau lactic acidosis. Muaj ob hom xws li hom A lactic acidosis thiab hom B lactic acidosis. Ntawm lawv, hom A lactic acidosis tshwm sim vim qhov nce ntawm lactate tsim los ntawm cov ntaub so ntswg hypoxia. Hom B lactic acidosis tshwm sim vim kev noj tshuaj thiab co toxins, uas ua rau muaj kev tsim ntau ntxiv.
Lactate Dehydrogenase yog dab tsi?
Lactate dehydrogenase yog ib qho enzyme uas tuaj yeem hloov lactate rau hauv pyruvate. Peb tuaj yeem qhia lub npe no li LDH enzyme lossis LD enzyme. Peb tuaj yeem pom cov enzyme no ze li ntawm txhua lub hlwb nyob. Tsis tas li ntawd, cov enzyme no tuaj yeem ua rau ob qho tib si rau pem hauv ntej thiab rov qab kev cuam tshuam ntawm kev hloov pauv ntawm lactate rau hauv pyruvate.
Cov enzyme no hloov lactate rau hauv pyruvate thiab rov qab los ntawm kev hloov NAD + rau hauv NADH. Hauv lwm lo lus, ib qho dehydrogenase enzyme tuaj yeem hloov cov hydride ntawm ib lub molecule mus rau lwm qhov. Peb tuaj yeem pom lactate dehydrogenase enzyme hauv cov ntaub so ntswg hauv lub cev, suav nrog cov qe ntshav thiab cov leeg nqaij vim tias cov enzyme no raug tso tawm thaum cov ntaub so ntswg puas lawm.
Daim duab 02: Lactate Dehydrogenase
Thaum muaj qhov siab ntawm lactate dehydrogenase, lactate dehydrogenase enzyme nyiam ua rau pom cov lus tawm tswv yim uas ua rau tus nqi hloov pauv ntawm pyruvate rau lactate kom txo. Ntxiv mus, qhov enzyme no tuaj yeem ua rau lub cev dehydrogenation ntawm 2-hydroxybutyrate.
Thaum xav txog cov qauv tshuaj ntawm lactate dehydrogenase enzyme, hauv tib neeg, cov enzyme no siv Nws (193) ua tus txais proton thiab ua haujlwm nrog rau coenzyme thiab substrate khi qhov chaw. Nws (193) qhov chaw nquag no tuaj yeem pom hauv LDH enzyme ntawm ntau lwm yam tsiaj thiab.
Qhov txawv ntawm Lactate thiab Lactate Dehydrogenase yog dab tsi?
Lub hauv paus conjugate ntawm lactic acid yog lactate anion. Lactate hloov mus rau hauv pyruvate nyob rau hauv lub xub ntiag ntawm lactate dehydrogenase enzyme. Qhov sib txawv tseem ceeb ntawm lactate thiab lactate dehydrogenase yog tias lactate yog daim ntawv deprotonated ntawm lactic acid, whereas lactate dehydrogenase yog ib qho enzyme uas tseem ceeb hauv kev hloov lactate rau hauv pyruvate.
Cov infographic hauv qab no teev qhov sib txawv ntawm lactate thiab lactate dehydrogenase hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Lactate vs Lactate Dehydrogenase
Lub hauv paus conjugate ntawm lactic acid yog lactate anion. Lactate hloov mus rau hauv pyruvate nyob rau hauv lub xub ntiag ntawm lactate dehydrogenase enzyme. Qhov sib txawv tseem ceeb ntawm lactate thiab lactate dehydrogenase yog tias lactate yog daim ntawv deprotonated ntawm lactic acid, whereas lactate dehydrogenase yog ib qho enzyme uas tseem ceeb hauv kev hloov lactate rau hauv pyruvate.
