Qhov sib txawv tseem ceeb ntawm fibronectin thiab vitronectin yog tias fibronectin yog lub siab molecular hnyav cell-adhesive glycoprotein ib txwm pom muaj nyob rau hauv cov ntshav thiab extracellular matrix, thaum vitroectin yog ib qho hnyav molecular cell-adhesive glycoprotein ib txwm pom nyob rau hauv cov ntshav, extracellular matrix., thiab pob txha.
Fibronectin thiab vitronectin yog ob lub cell nplaum glycoproteins. Cell adhesive glycoproteins tseem hu ua multifunctional adhesive glycoproteins. Lawv yog ib feem ntawm cov proteins feem ntau nyob rau hauv cov ntshav thiab extracellular matrix. Hauv paus, feem ntau cov nplaum glycoproteins khi cov hlwb los ntawm cov cell nto receptor integrin. Lawv kuj tuaj yeem khi rau lwm cov receptors xws li dystroglycans thiab syndecans. Lawv cuam tshuam nrog cov receptors no thiab nrog rau lwm cov proteins matrix extracellular los tsim ib qho kev sib koom ua ke sib zog. Cell adhesion yog ib qho tseem ceeb hauv kev tswj cov ntaub so ntswg thiab kev ua haujlwm.
Fibronectin yog dab tsi?
Fibronectin yog lub siab molecular hnyav cell adhesion glycoprotein pom nyob rau hauv cov ntshav plasma thiab extracellular matrix. Nws yog qhov hnyav molecular (500 kDa) glycoprotein. Fibronectin feem ntau khi rau lub cell nto receptor hu ua "integrin." Fibronectin kuj khi rau lwm cov proteins hauv matrix extracellular xws li collagen, fibrin, heparin sulfate, proteoglycans (syndecans), thiab lwm yam. Cov protein no tshwm sim raws li ib tug dimer. Nws muaj ob ze li zoo tib yam monomers txuas los ntawm ib khub ntawm disulfide bonds. FN1 gene codes rau fibronectin protein.
Daim duab 01: Fibronectin
Feem ntau, cov protein fibronectin yog tsim los ntawm tib lub noob. Tab sis lwm txoj kev splicing ntawm pre mRNA ntawm cov protein no tsim ntau isoforms ntawm cov protein no.
Hom thiab Kev Ua Haujlwm ntawm Fibronectins
Ob hom fibronectins muaj nyob rau hauv vertebrates li soluble plasma fibronectin thiab insoluble cellular fibronectin. Soluble plasma fibronectin yog ib feem ntawm cov ntshav plasma, thiab nws yog tsim nyob rau hauv daim siab los ntawm hepatocytes. Insoluble cellular fibronectin yog ib feem ntawm extracellular matrix. Nws yog secreted los ntawm ntau lub hlwb xws li fibroblasts. Tsis tas li ntawd, cov protein no ua lub luag haujlwm tseem ceeb hauv cell adhesion, kev loj hlob, kev tsiv teb tsaws, thiab kev sib txawv. Nws kuj tseem ceeb heev rau kev kho mob thiab kev loj hlob ntawm embryonic. Cov kev hloov pauv, degradation, thiab lub koom haum ntawm cov protein no tau cuam tshuam nrog ntau yam kab mob xws li mob qog noj ntshav, mob caj dab, thiab fibrosis.
Vitronectin yog dab tsi?
Vitronectin yog qhov hnyav molecular cell-adhesive glycoprotein pom nyob rau hauv cov ntshav, extracellular matrix, thiab pob txha. Nws qhov hnyav molecular yog nyob ib ncig ntawm 54 kDa. Vitronectin belongs rau tsev neeg hemopexin. Hauv tib neeg, cov gene coding no protein yog VTN gene. Vitronectin feem ntau khi rau ntawm tes saum npoo receptors hu ua integrin alpha-Vbeta-3 thiab yog li txhawb nqa cell adhesion thiab kis.
Daim duab 02: Vitronectin
Tsis tas li ntawd, nws inhibits daim nyias nyias cov nyhuv ntawm lub davhlau ya nyob twg cytolytic ntxiv txoj hauv kev. Nws kuj khi rau ntau yam serine protease inhibitors zoo li serpins. Cov protein no yog cov protein uas zais cia. Nws tshwm sim raws li ib daim ntawv ib leeg los yog ob daim ntawv chains. Yog hais tias nws tshwm sim raws li ob daim ntawv chains, cov chains yog tuav ua ke los ntawm ib tug disulfide daim ntawv cog lus. Tsis tas li ntawd, cov protein no tau kwv yees tias muaj feem cuam tshuam rau cov qog malignancy.
Dab tsi zoo sib xws ntawm Fibronectin thiab Vitronectin?
- Fibronectin thiab vitronectin yog cell nplaum proteins.
- YLawv yog glycoproteins.
- Lawv ob leeg khi rau lub cell nto receptor hu ua "inetgrin."
- Lawv muaj nyob rau hauv extracellular matrix.
- Kev hloov pauv ntawm cov proteins no ua rau mob qog noj ntshav.
Qhov txawv ntawm Fibronectin thiab Vitronectin yog dab tsi?
Fibronectin yog lub siab molecular hnyav cell-adhesive glycoprotein hauv ntshav plasma thiab extracellular matrix. Ntawm qhov tod tes, vitronectin yog ib qho tsis tshua muaj molecular hnyav cell-adhesive glycoprotein hauv cov ntshav, extracellular matrix, thiab pob txha. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm fibronectin thiab vitronectin. Tsis tas li ntawd, kev hloov pauv, kev degradation, thiab lub koom haum ntawm fibronectin tau cuam tshuam nrog ntau yam kab mob xws li mob qog noj ntshav, mob caj dab, thiab fibrosis, thaum hloov kev qhia ntawm vitronectin tau koom nrog cov kab mob xws li qog malignancy. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm fibronectin thiab vitronectin.
Cov hauv qab no infographic tabulates qhov sib txawv ntawm fibronectin thiab vitroectin.
Summary – Fibronectin vs Vitronectin
Cell adhesion yog txheej txheem uas cov hlwb cuam tshuam thiab txuas rau ib leeg. Cell nplaum glycoproteins khi cov hlwb los ntawm cov cell nto integrin receptors nrog rau lwm cov cell nto receptors. Fibronectin thiab vitronectin yog ob lub cell nplaum glycoproteins. Fibronectin yog ib qho hnyav molecular hnyav cell-adhesive glycoprotein uas ib txwm pom muaj nyob rau hauv cov ntshav plasma thiab extracellular matrix. Ntawm qhov tod tes, vitronectin yog ib qho tsis tshua muaj molecular hnyav cell-adhesive glycoprotein uas ib txwm pom muaj nyob rau hauv cov ntshav, extracellular matrix, thiab pob txha. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm fibronectin thiab vitronectin.
