Qhov sib txawv tseem ceeb ntawm fibronectin thiab laminin yog tias fibronectin yog glycoprotein uas muaj nyob rau hauv lub extracellular matrix thiab ntshav plasma thaum laminin yog glycoprotein uas muaj nyob rau hauv lub basal lamina.
Extracellular matrix, uas yog nyob nruab nrab ntawm cov ntaub so ntswg thiab cov kabmob nyob ib puag ncig cov hlwb thiab muab cov qauv thiab biochemical txhawb rau lub hlwb. Nws muaj cov khoom sib txawv xws li collagen, enzymes, thiab glycoproteins. Fibronectin thiab laminin yog ob qho tseem ceeb glycoproteins pom nyob rau hauv extracellular matrix. Ob leeg yog siab molecular hnyav proteins ua ke nrog oligosaccharides. Tsis tas li ntawd, fibronectin thiab laminin khi nrog sib txawv ntawm cov xov tooj ntawm tes-nto cellular adhesion molecules thiaj li pab txhawb kev ua kom cov cell adhesion. Yog li, cov molecules no yog qhov tseem ceeb hauv cell adhesion nrog rau kev tsiv teb tsaws thiab kev sib txawv.
Fibronectin yog dab tsi?
Fibronectin yog qhov hnyav molecular glycoprotein tam sim no nyob rau hauv extracellular matrix. Lawv khi nrog integrins, uas yog trans-membrane receptor proteins. Fibronectin khi feem ntau nrog collagen fibers nyob rau hauv lub extracellular matrix thiab pab nyob rau hauv lub cell txav los ntawm lub matrix. Cells secrete cov fibronectins.
Daim duab 01: Fibronectin
Thaum pib, fibronectin tshwm sim raws li daim ntawv tsis muaj zog. Thaum lawv khi nrog integrins, lawv tsim dimmers thiab ua haujlwm zoo. Sib nrug los ntawm kev pab lub zog ntawm tes, fibronectins pab tsim cov ntshav txhaws ntawm qhov chaw ntawm kev raug mob txhawm rau tiv thaiv los ntshav. Yog li ntawd, lawv yog ib qho tseem ceeb hauv kev kho qhov txhab.
Laminin yog dab tsi?
Laminin kuj yog glycoprotein muaj nyob rau hauv cov protein ntxiv. Txawm li cas los xij, laminin feem ntau muaj nyob rau hauv lub basal lamina, uas yog ib feem ntawm lub extracellular matrix. Laminin kuj yog ib qho protein ntau molecular hnyav. Nws muaj peb subunits: α, β, thiab γ chains. Ntxiv mus, Laminin muaj peev xwm khi nrog lwm cov proteins uas muaj nyob rau hauv lub extracellular matrix, uas qhia cov khoom zoo ib yam li fibronectin. Li no, nws pab txhawb cov qauv ntawm cov qauv matrix extracellular thiab pab cell adhesion.
Daim duab 02: Laminin
Tsis tas li ntawd, laminin yog ib qho tseem ceeb ntawm lub ntsws hauv qab daim nyias nyias thiab muab kev txhawb nqa rau lub ntsws. Qhov tseem ceeb tshaj plaws, laminin yog qhov tseem ceeb rau kev txhim kho neural thiab kho cov hlab ntsha peripheral.
Dab tsi yog qhov zoo sib xws ntawm Fibronectin thiab Laminin?
- Fibronectin thiab laminin yog ob hom molecular-yuag glycoproteins nyob rau hauv extracellular matrix.
- YLawv yog cov protein.
- Tsis tas li, ob qho tib si tseem ceeb heev hauv kev sib txuas ntawm tes, tsiv teb tsaws, kev loj hlob, thiab sib txawv.
- Ntxiv mus, ob qho tib si proteins tuaj yeem khi nrog lwm cov proteins uas muaj nyob rau hauv extracellular matrix.
- Tsis tas li ntawd, ob qho tib si molecules pab txhawb cov txheej txheem ntawm cov cellular matrix.
Qhov txawv ntawm Fibronectin thiab Laminin yog dab tsi?
Fibronectin yog glycoprotein pom nyob rau hauv extracellular matrix thaum laminin yog lwm glycoprotein feem ntau muaj nyob rau hauv lub basal lamina ntawm lub epithelia. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm fibronectin thiab laminin. Tsis tas li ntawd, cov qauv sib txawv ntawm fibronectin thiab laminin yog qhov fibronectin yog homodimer thaum laminin yog heterodimer.
Ntxiv mus, fibronectin yog cov protein ntau molecular hnyav, uas yog li ~ 440 kDa hauv qhov hnyav thaum lub cev hnyav ntawm laminin yog ~ 400 txog ~ 900 kDa. Yog li, peb tuaj yeem xav txog qhov no kuj yog qhov sib txawv ntawm fibronectin thiab laminin. Tsis tas li ntawd, fibronectin tseem ceeb hauv kev kho qhov txhab thaum laminin tseem ceeb hauv kev tsim cov neurons thiab kho cov hlab ntsha peripheral. Yog li, qhov no yog qhov sib txawv ntawm fibronectin thiab laminin.
Summary – Fibronectin vs Laminin
Fibronectin thiab laminin yog ob glycoproteins uas muaj nyob rau hauv extracellular matrix. Lawv yog cov proteins uas hnyav molecular uas tuaj yeem khi nrog lwm cov proteins thiab pab hauv kev sib txuas ntawm tes thiab txav ntawm tes. Fibronectins yog lub luag haujlwm rau kev kho qhov txhab vim lawv koom nrog hauv cov ntshav txhaws. Ntawm qhov tod tes, laminin yog qhov tseem ceeb rau kev txhawb nqa cov qauv matrix extracellular, hauv kev txhim kho neural thiab kho cov hlab ntsha peripheral. Tsis tas li ntawd, fibronectin yog homodimer thaum laminin yog heterodimer. Yog li, qhov no qhia txog qhov sib txawv ntawm fibronectin thiab laminin.
