Qhov sib txawv tseem ceeb ntawm mitogen thiab kev loj hlob yog tias mitogen yog cov protein me me uas ua rau lub cell pib faib cov cell, thaum loj hlob yog ib yam khoom tshwm sim uas muaj peev xwm txhawb nqa cell proliferation, kho qhov txhab, thiab cellular. sib txawv.
Mitogen thiab kev loj hlob yog ob feem cuam tshuam hauv lub voj voog ntawm tes. Lub voj voog ntawm tes yog cov xwm txheej uas tshwm sim hauv ib lub xov tooj ntawm tes. Los ntawm txoj kev no, ib lub cell loj hlob thiab faib. Lub voj voog ntawm tes muaj ob theem tseem ceeb: interphase (G1, S, G2) thiab mitosis. Thaum lub sij hawm interphase, lub cell loj hlob thiab replicates nws DNA. Nyob rau theem mitosis, lub xovtooj ntawm tes tau txais kev faib tawm nuclear.
Mitogen yog dab tsi?
Mitogen yog peptide lossis cov protein me me uas ua rau cov cell pib faib cov cell. Mitogenesis yog tus txheej txheem ntawm kev ua rau mitosis, feem ntau ntawm mitogen. Feem ntau cov haujlwm ntawm mitogen yog ua kom cov teeb liab hloov txoj hauv kev xws li mitogen-activated protein kinase (MAPK). Qhov no ua rau mitosis.
Daim duab 01: Mitogen
Mitogens feem ntau cuam tshuam rau pawg proteins. Cov proteins no koom nrog hauv kev txwv ntawm kev loj hlob los ntawm lub voj voog ntawm tes. G1 checkpoint yog ncaj qha tswj los ntawm mitogens. Tab sis kev hloov pauv ntawm tes txuas ntxiv tsis xav tau mitogen txuas ntxiv mus. Qhov taw tes hauv lub voj voog ntawm tes uas mitogens tsis tas yuav txav mus rau pem hauv ntej hauv lub voj voog ntawm tes yog hu ua qhov txwv tsis pub. Cov protein uas paub zoo uas tau txais los ntawm mitogens yog mitogen-activated kinase.
Muaj ob hom mitogens ua endogenous lossis exogenous yam. Ib qho piv txwv ntawm endogenous mitogen yog endogenous mitogen Nrg1 hauv Zebrafish. Qhov zoo tshaj plaws no txhawb kev ua kom cov cell faib thiab tsim cov txheej txheem tshiab ntawm cov leeg hlwb thaum lub plawv puas. Ib qho piv txwv ntawm exogenous mitogen yog exogenous PDGF. Nws yog ib qho muaj zog mesangial cell mitogen. Mitogens tseem ceeb heev hauv cov qog nqaij hlav vim lawv cuam tshuam rau lub voj voog ntawm tes. Cov qog nqaij hlav cancer plam lawv qhov kev vam khom ntawm mitogens.
Qhov Kev Loj Hlob yog dab tsi?
Qhov kev loj hlob yog ib yam khoom tshwm sim uas muaj peev xwm txhawb kev loj hlob ntawm tes, kho qhov txhab, thiab qee zaus, kev sib txawv ntawm tes. Nws yog ib qho secreted protein los yog steroid hormone. Qhov loj hlob zoo yog ib lo lus uas siv sib hloov los ntawm cov kws tshawb fawb nrog lub sij hawm cytokines. Cov txiaj ntsig loj hlob tau pom thawj zaug los ntawm Rita Levi-Montalcini, uas yeej Nobel nqi zog rau nws qhov kev tshawb pom hauv xyoo 1986.
Daim duab 02: Kev Loj Hlob
Txoj kev loj hlob tseem ceeb heev rau kev tswj cov txheej txheem ntawm tes. Kev loj hlob yam ua raws li kev taw qhia cov molecules ntawm cov hlwb. Piv txwv li cytokines thiab cov tshuaj hormones. Cov no khi rau cov receptors tshwj xeeb ntawm qhov chaw ntawm lawv lub hom phiaj hlwb. Lawv feem ntau txhawb kev sib txawv ntawm tes thiab kev loj hlob. Piv txwv li, tus kab mob epidermal loj hlob zoo (EGF) txhim kho osteogenic sib txawv. Ntxiv mus, fibroblast kev loj hlob yam thiab vascular endothelial kev loj hlob yam txhawb nqa cov hlab ntsha sib txawv.
Qhov Zoo sib xws ntawm Mitogen thiab Growth Factor yog dab tsi?
- Mitogen thiab qhov loj hlob tuaj koom nrog hauv lub voj voog ntawm tes.
- Ob leeg tuaj yeem cuam tshuam cov chaw kuaj xyuas ntawm lub voj voog ntawm tes.
- Lawv deregulation ua rau mob qog noj ntshav.
- Ob leeg pab hauv kev loj hlob ntawm tib neeg.
Qhov txawv ntawm Mitogen thiab Growth Factor yog dab tsi?
Mitogen yog cov protein me me uas ua rau cov cell pib faib cov cell. Ntawm qhov tod tes, qhov kev loj hlob zoo yog ib yam khoom tshwm sim uas muaj peev xwm txhawb kev loj hlob ntawm tes, kho qhov txhab, thiab qee zaus, kev sib txawv ntawm tes. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm mitogen thiab kev loj hlob. Ntxiv mus, mitogen yog ib qho protein me me. Hauv qhov sib piv, qhov kev loj hlob yog ib qho protein uas zais cia lossis cov tshuaj steroid.
Cov hauv qab no infographic teev qhov sib txawv ntawm mitogen thiab kev loj hlob zoo hauv daim ntawv teev npe.
Summary – Mitogen vs Growth Factor
Lub voj voog ntawm tes yog ib ntu ntawm cov xwm txheej uas tshwm sim hauv lub xov tooj txhawm rau npaj lub cell rau kev faib. Hauv interphase, lub xov tooj ntawm tes nce qhov loj, thiab nws cov DNA replicates. Lub cell faib nyob rau hauv lub mitosis theem. Tej yam tshuaj tswj tag nrho cov txheej txheem no. Mitogens thiab kev loj hlob yam tseem ceeb heev rau kev tswj lub voj voog ntawm tes. Mitogen induces lub cell los pib cell faib. Ntawm qhov tod tes, kev loj hlob zoo muaj peev xwm txhawb kev loj hlob ntawm tes, kho qhov txhab, thiab kev sib txawv ntawm tes. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm mitogen thiab kev loj hlob zoo.
