Qhov sib txawv tseem ceeb ntawm adapter thiab scaffold protein yog cov protein ntau yog cov protein me me uas khi tsuas yog ob lub proteins koom nrog hauv txoj kev taw qhia, thaum scaffold protein yog cov protein ntau uas khi rau ntau cov protein sib txawv. hauv txoj kev taw qhia.
Ib txoj kev taw qhia yog ib txoj hauv kev uas lub teeb liab mus txog lub hlwb thiab ua rau qee qhov kev cuam tshuam lossis xaj cov xwm txheej. Qhov no ua rau qee qhov kev hloov pauv hauv lub xov tooj ntawm tes, uas feem ntau cuam tshuam nrog cov kev qhia gene lossis kev daws teeb meem. Thaum kawg, tag nrho cov kev hloov pauv no tso cai rau lub xov tooj ntawm tes los teb cov teeb liab thiab kho nws cov metabolism raws li cov xwm txheej tam sim no. Adapter protein thiab scaffold protein yog ob hom proteins koom nrog hauv txoj kev taw qhia.
Dab tsi yog Adapter Protein?
Adaptor protein yog cov protein me me uas feem ntau khi rau ob lub proteins hauv txoj kev taw qhia los tswj cov teeb liab hloov. Lawv ua tiav qhov no los ntawm qee qhov tshwj xeeb xws li SH2 thiab SH3, uas paub txog qee cov amino acid sequences hauv cov hom phiaj protein. Qee zaum, nws tseem hu ua signal-transducing adapter proteins (STAPs). Adapter protein feem ntau muaj ntau lub npe, suav nrog Src homology 2 (SH2) thiab Src homology 3 (SH3) domains. SH2 domains paub txog cov amino acid sequences nyob rau hauv cov proteins uas muaj phosphotyrosine residues. Ntawm qhov tod tes, SH3 domains paub txog cov kev nplua nuj nyob hauv cov proteins tshwj xeeb.
Daim duab 01: Adapter Protein
Adaptor proteins tsis muaj kev ua haujlwm hauv lub cev. Lawv txoj haujlwm yog los kho cov kev sib tshuam ntawm cov protein-protein uas ua rau kev tsim cov protein ntau. Ib qho piv txwv zoo tshaj plaws ntawm adapter protein yog GRB2 (kev loj hlob zoo receptor-bound protein 2). Cov protein no xa cov teeb liab txuas ntxiv mus rau hauv txoj kev taw qhia los ntawm kev khi los ntawm SH2 sau mus rau lwm tus receptor EGF (epidermal growth factor receptor). Nws nyiam cov protein tom ntej hauv txoj hauv kev (Sos protein hauv qhov piv txwv no) los ntawm kev khi los ntawm SH3 domains. MYD88 thiab SHC1 yog ob qho piv txwv ntxiv ntawm adapter proteins.
Scaffold Protein yog dab tsi?
Scaffold protein yog cov protein loj uas cuam tshuam nrog ntau cov proteins ntawm txoj kev taw qhia kom tswj tau cov teeb liab. Tom qab kev sib txuas, scaffold protein tethers cov protein ntau no rau hauv cov complexes. Qhov zoo tshaj plaws-paub piv txwv ntawm scaffold protein yog MEKK1 protein. Qhov no muaj nyob rau hauv MAPK txoj kev (mitogen-activated protein kinase). Txoj kev no yog lub luag haujlwm rau kev qhia cov proteins, uas cuam tshuam rau lub voj voog ntawm tes thiab kev sib txawv ntawm tes. Rau lub hom phiaj no, nws xa cov teeb liab ntxiv mus rau hauv lub nucleus txhawm rau tswj hwm cov xwm txheej tshwj xeeb.
Daim duab 02: Scaffold Protein
Nyob hauv txoj kev zoo li no, cov protein no tswj cov teeb liab hloov pauv thiab pab txhim kho txoj hauv kev mus rau thaj chaw tshwj xeeb xws li plasma membrane, cytoplasm, nucleus, Golgi apparatus, endosomes, thiab mitochondria. Scaffold protein muaj plaub txoj haujlwm hauv qab no.
- Nws muaj peev xwm tether signaling Cheebtsam.
- Nws localises signaling Cheebtsam rau tej thaj chaw ntawm tes,
- Nws tswj cov teeb liab hloov pauv los ntawm kev sib koom tes tawm tswv yim zoo thiab tsis zoo.
- Nws insulates qhov tseeb qhia cov proteins los ntawm cov protein sib tw.
Dab tsi yog qhov Zoo sib xws Adapter thiab Scaffold Protein?
- Adaptor thiab scaffold protein yog ob hom proteins.
- Lawv koom hauv kev taw qhia txoj hauv kev.
- Lawv yog ob qho tib si ua ke nrog lwm cov cim qhia cov proteins.
- Lub luag haujlwm ntawm ob qho proteins no tseem ceeb heev rau lub voj voog ntawm tes, sib txawv ntawm tes thiab cov metabolism.
Qhov txawv ntawm Adapter thiab Scaffold Protein yog dab tsi?
Adaptor protein feem ntau yog cov protein me me uas khi rau ob lub proteins uas koom nrog hauv txoj kev taw qhia. Ntawm qhov tod tes, scaffold protein yog cov protein ntau uas khi rau ntau cov proteins sib txawv koom nrog hauv txoj kev taw qhia. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm adapter thiab scaffold protein. Tsis tas li ntawd, ib qho adapter protein ua rau lub neej luv luv nrog rau lwm cov proteins qhia. Nyob rau hauv sib piv, scaffold protein cov ntaub ntawv ruaj khov complexes nrog rau lwm yam signaling proteins. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm adapter thiab scaffold protein.
Cov hauv qab no qhia ntau qhov sib txawv ntawm adapter thiab scaffold protein nyob rau hauv daim ntawv tabular.
Summary – Adapter vs Scaffold Protein
Ib txoj kev taw qhia yog cov tshuaj lom neeg cov tshuaj tiv thaiv uas ib pab pawg ntawm cov molecules hauv ib lub xovtooj ua haujlwm ua ke los tswj kev ua haujlwm ntawm tes. Ib lub xovtooj ntawm tes tau txais cov cim los ntawm cov molecules zoo li cov yam ntxwv loj hlob thaum lawv khi rau cell receptors. Tom qab thawj molecule nyob rau hauv txoj kev tau txais ib lub teeb liab, nws activates lwm molecule. Cov txheej txheem no rov ua dua thoob plaws txhua txoj kev taw qhia. Adapter thiab scaffold proteins tau koom nrog hauv txoj kev taw qhia. Adapter protein feem ntau khi tsuas yog rau ob lub proteins koom nrog hauv txoj kev taw qhia. Ntawm qhov tod tes, scaffold protein khi rau ntau cov proteins sib txawv koom nrog hauv txoj kev taw qhia thiab tswj cov teeb liab hloov. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm adapter thiab scaffold protein.
