Qhov txawv ntawm Quiescent thiab Senescent Cells

2024 Tus sau: Alex Aldridge | [email protected]. Kawg hloov kho: 2023-12-17 13:40

Qhov sib txawv tseem ceeb ntawm quiescent thiab senescent hlwb yog cov quiescent hlwb nyob rau hauv lub reversible G₀ state thaum senescent hlwb nyob rau hauv lub irreversible G_0xeev.

Feem ntau, lub voj voog ntawm tes muaj G₁, S, G₂, mitosis (nuclear division) thiab cytokinesis. Kev faib cov hlwb tau dhau los ntawm tag nrho cov theem no, thiab nws yog lub npe hu ua lub voj voog ntawm tes. G₀ phase yog lub xeev cellular uas nyob sab nraud ntawm lub voj voog ntawm tes. Hauv G₀ theem, cov hlwb nyob hauv lub xeev ntawm lub voj voog ntawm tes raug ntes. Yog li ntawd, cov hlwb tsis sib faib. G₀ theem tshwm sim vim muaj ntau yam. Muaj peb G_{0 xeev: quiescence, senescence thiab sib txawv. Quiescence yog lub xeev thim rov qab, thaum ob qho tib si senescence thiab kev sib txawv yog cov xeev uas tsis tuaj yeem hloov tau. Quiescence tshwm sim vim tsis muaj khoom noj khoom haus thiab kev loj hlob yam tseem ceeb thaum senescence tshwm sim vim kev laus thiab kev puas tsuaj DNA loj.}

Cov Cell Quiescent yog dab tsi?

Quiescence yog qhov thim rov qab G_{0 xeev. Yog li ntawd, cov cell uas nyob rau hauv quiescence yog quiescent cells. Cov hlwb quiescent yog nyob rau theem tsis ua haujlwm. Cells nkag mus rau hauv lub xeev quiescent vim tsis muaj kev noj haus thiab kev loj hlob yam. Cov hlwb Quiescent yog tus cwj pwm los ntawm cov ntsiab lus RNA tsawg, tsis muaj cov cim kev loj hlob ntawm tes thiab nce daim ntawv tuav pov hwm, qhia tias tsis muaj kev hloov pauv ntawm tes. Quiescent cells nyob ntawm so. Lawv tuaj yeem qhib tau thiab rov nkag mus rau lub voj voog ntawm tes. Quiescence muaj txiaj ntsig zoo, thiab nws ncua kev laus ntawm qia cell.}

Daim duab 01: G0 Theem ntawm Cells

Senescent Cells yog dab tsi?

Senescence yog lub xeev ntawm kev ruaj khov ntawm lub voj voog kaw. Hauv lwm lo lus, senescence yog G_{0 xeev uas tsis tuaj yeem thim rov qab. Cov hlwb uas nyob rau theem senescence yog hu ua senescent cells. Senescence tshwm sim vim kev laus thiab kev puas tsuaj DNA loj. Yog li ntawd, cov cell tsis tuaj yeem rov nkag mus rau lub voj voog ntawm tes. Senescent hlwb tsis tuaj yeem rov ua dua. Ntxiv mus, senescence yog ib tug degenerative txheej txheem.}

Daim duab 02: Senescent Cells

Txawm tias cov hlwb tsis sib faib, cov hlwb tseem ua haujlwm tau zoo thiab ua haujlwm metabolically rau qee lub sijhawm. Txij li thaum senescent tiv thaiv kev rov ua dua, nws ua haujlwm tseem ceeb los tiv thaiv qog noj ntshav.

Dab tsi zoo sib xws ntawm Quiescent thiab Senescent Cells?

• Ob qho tib si quiescence thiab senescence yog ob lub xeev ntawm kev ruaj khov ntawm lub voj voog kaw.
• Quiescent thiab senescent hlwb nyob hauv G_{0 xeev, uas yog lub xeev tsis muaj zog.}
• Yog li ntawd, ob hom cell nres nquag sib faib.
• Yog li ntawd, ob qho tib si quiescent thiab senescent hlwb nyob twj ywm thiab metabolically active.
• Cov noob qhia hauv cov hlwb quiescent tuaj yeem thaiv kev laus.

Qhov txawv ntawm Quiescent thiab Senescent Cells yog dab tsi?

Quiescent cells tuaj yeem rov nkag mus rau lub voj voog ntawm tes, thaum lub hlwb tsis tuaj yeem rov nkag mus rau lub voj voog ntawm tes. Yog li ntawd, quiescent hlwb nyob rau hauv lub reversible G₀ xeev, thaum senescent hlwb nyob rau hauv lub irreversible G_{0 xeev. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm quiescent thiab senescent hlwb. Tsis tas li ntawd, quiescence tshwm sim vim tsis muaj khoom noj khoom haus thiab kev loj hlob, thaum senescence tshwm sim vim kev laus thiab kev puas tsuaj DNA loj.}

Hauv qab infographic tabulates qhov sib txawv ntawm quiescent thiab senescent hlwb rau ib sab ntawm kev sib piv.

Summary – Quiescent vs Senescent Cells

Ob lub hlwb quiescent thiab senescent tsis yog cov hlwb uas nyob hauv lub xeev ntawm lub voj voog ntawm tes los yog G₀ theem. Quiescence yog qhov hloov pauv tau G₀ xeev. Yog li ntawd, quiescent cells tuaj yeem rov nkag mus rau lub voj voog ntawm tes. Hauv qhov sib piv, senescence yog ib qho irreversible G_{0 xeev. Yog li ntawd, senescent hlwb tsis tuaj yeem rov nkag mus rau lub voj voog ntawm tes. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm quiescent thiab senescent hlwb. Tsis tas li ntawd, cov hlwb quiescent raug tsim los ntawm qhov tsis muaj khoom noj khoom haus thiab kev loj hlob yam tseem ceeb thaum laus thiab DNA puas tsuaj loj tsim cov hlwb senescent.}