Qhov sib txawv tseem ceeb ntawm catecholamines thiab noncatecholamines yog tias catecholamines feem ntau yog cov tshuaj adrenergic ncaj qha uas muaj catechol, thaum uas tsis yog catecholamine tuaj yeem ua ncaj qha, tsis ncaj-ua yeeb yam, lossis ob-ua yeeb yam adrenergic tshuaj uas tsis muaj catechol.
tshuaj adrenergic ua raws li cov teebmeem ntawm adrenergic paj hlwb stimulation. Catecholamines thiab noncatecholamines yog ob hom tshuaj adrenergic. Lawv tuaj yeem ua yeeb yam ncaj qha lossis tsis ncaj qha. Indirect acting tshuaj tsis khi rau receptors, tab sis ncaj qha receptors khi rau receptors. Tsis tas li ntawd, cov tshuaj ua yeeb yam ncaj qha yog qhov tshwj xeeb, thaum cov tshuaj ua yeeb yam tsis ncaj qha tsis yog tshwj xeeb. Catecholamines qhia ntau yam agonistic ua ntawm cov adrenoceptors. Lawv feem ntau yog direct-acting. Noncatecholamines tuaj yeem ua ncaj qha, ua tsis ncaj, lossis ua ob zaug.
Catecholamines yog dab tsi?
Catecholamines yog ntau yam amines uas ua haujlwm li cov tshuaj hormones lossis neurotransmitters lossis ob qho tib si. Tus qauv, 3, 4, dihydroxybenzenes hu ua catechol. Yog li, cov tshuaj uas muaj cov qauv no hu ua catecholamines. Adrenergic neurons tso tawm synaptic vesicles uas muaj catecholamines. Catecholamine synthesis xav tau lub precursor hu ua tyrosine. Muaj cov catecholamines endogenous uas tshwm sim hauv lub cev. Epinephrine, norepinephrine thiab dopamine yog qee qhov ntuj catecholamines. Tseem muaj cov hluavtaws catecholamines thiab. Isoproterenol, dobutamine thiab rimiterol yog ntau yam catecholamines hluavtaws. Tag nrho cov catecholamines muaj peev xwm ua rau arrhythmogenic. Qee qhov ua rau kub siab. Tsis tas li ntawd, qee qhov ua rau muaj kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb xws li kev ntshai, kev ntxhov siab thiab nyob tsis tswm.
Daim duab 01: Catecholamine
Catecholamines yog ib hom tshuaj adrenergic. Lawv tsis muaj txiaj ntsig los ntawm txoj kev ntawm qhov ncauj. Li no, lawv feem ntau yog muab parenterally. Catecholamines muaj luv luv ib nrab-lub neej vim lawv cov metabolism sai. Lawv qhia ncaj qha kev txiav txim thiab muaj kev sib raug zoo rau adrenoceptors. Catecholamines tsis tuaj yeem hla cov hlab ntsha hauv hlwb. Yog li ntawd, lawv muaj qhov cuam tshuam tsawg kawg rau CNS.
Noncatecholamines yog dab tsi?
Noncatecholamines yog pawg thib ob ntawm cov tshuaj adrenergic. Noncatecholamines tsis muaj pawg hydroxyl ntawm lub nplhaib benzene. Feem ntau cov uas tsis yog-catecholamines tau siv qhov ncauj. Lawv muaj qhov nruab nrab rau qhov tsis zoo rau cov adrenoceptors. Qhov tseem ceeb tshaj plaws, cov tshuaj noncatecholamines qeeb qeeb. Yog li ntawd, lawv muaj ib nrab mus rau ntev ib nrab-lub neej. Ntxiv mus, noncatecholamines tuaj yeem hla cov ntshav-hlwb teeb meem thiab pom muaj nyob rau hauv siab ntau hauv lub hlwb thiab cerebrospinal kua. Yog li, lawv tuaj yeem tsim muaj txiaj ntsig zoo rau CNS. Noncatecholamines tuaj yeem ua ncaj qha, ua tsis ncaj, lossis ua ob yam. Ephedrine, Amphetamine, Methyl-amphetamine thiab Methyl phenidate yog ob peb yam piv txwv ntawm noncatecholamines.
Dab tsi yog qhov zoo sib xws ntawm Catecholamines thiab Noncatecholamines?
- Ob leeg catecholamines thiab noncatecholamines yog neurotransmitters lossis hormones.
- Lawv yog adrenergic agonists uas ua raws li cov teebmeem ntawm adrenergic paj hlwb stimulation.
- Metabolism thiab inactivation ntawm catecholamine thiab noncatecholamine tshwm sim hauv daim siab.
Qhov txawv ntawm Catecholamines thiab Noncatecholamines yog dab tsi?
Catecholamines yog cov tshuaj ua haujlwm ncaj qha adrenergic uas muaj catechol. Noncatecholamines yog cov tshuaj adrenergic uas tsis muaj catechol. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm catecholamines thiab noncatecholamines. Ntxiv mus, catecholamines yog ncaj qha-ua yeeb yam thaum uas tsis yog catecholamines yog ncaj qha-acting, indirect-acting, los yog dual-acting.
Ntxiv mus, lwm qhov sib txawv ntawm catecholamines thiab noncatecholamines yog tias catecholamines tsis tuaj yeem siv los ntawm qhov ncauj thaum uas tsis yog catecholamines tuaj yeem siv qhov ncauj. Tsis tas li ntawd, catecholamines muaj lub neej luv luv thaum tsis yog catecholamines muaj lub neej ntev dua. Adrenaline, Nor-adrenaline, Isoprenaline, Dopamine, thiab Dobutamine yog cov piv txwv ntawm catecholamines thaum Ephedrine, Amphetamine, Methyl-amphetamine, Methyl phenidate yog cov piv txwv ntawm noncatecholamines.
Cov ntawv qhia hauv qab no qhia ntau qhov sib txawv ntawm catecholamines thiab noncatecholamines rau ib sab ntawm kev sib piv.
Summary – Catecholamines vs Noncatecholamines
Catecholamines thiab noncatecholamines yog ob hom tshuaj adrenergic. Catecholamines yog cov tshuaj ua yeeb yam ncaj qha thaum uas tsis yog catecholamines yog cov yeeb yam ncaj qha, ua tsis ncaj lossis ua ob qho. Ntxiv mus, catecholamines muaj hydroxyl pawg ntawm txoj hauj lwm 3 thiab 4 ntawm benzene nplhaib thaum noncatecholamines tsis muaj ib lossis ob pawg hydroxyl. Yog li, qhov no qhia txog qhov sib txawv ntawm catecholamines thiab noncatecholamines.
