Qhov sib txawv tseem ceeb ntawm paracrine thiab juxtacrine yog qhov kev taw qhia paracrine xav tau kev tso tawm cov cim qhia rau hauv qhov chaw sab nraud thiab qhov sib txawv ntawm lawv nyob rau hauv qhov chaw thaum juxtacrine signaling xav tau kev sib cuag ntawm cov hlwb.
Cells sib txuas lus nrog ib leeg ntawm tes taw qhia. Ib lub xov tooj ntawm tes xa cov teeb liab mus rau lub xov tooj tau txais. Ib yam li ntawd, cov hlwb xa thiab tau txais ntau lab ntawm cov lus nyob rau hauv daim ntawv ntawm cov tshuaj chemical signaling molecules. Cell signaling pab cov hlwb kom paub tias muaj dab tsi tshwm sim nyob ib puag ncig lawv. Cells siv cov cim qhia tshuaj no los sib txuas lus. Cov cim qhia tshuaj tseem hu ua ligands yog cov proteins thiab lwm cov molecules uas tsim los ntawm kev xa xov ntawm tes. Lub hom phiaj ntawm tes yuav tsum muaj lub receptor thiaj li tau txais cov teeb liab tshuaj. Muaj plaub hom kev taw qhia ntawm tes hauv cov kab mob ntau yam. Lawv yog paracrine signaling, autocrine signaling, endocrine signaling, thiab juxtacrine signaling. Lawv txawv raws li qhov kev ncua deb ntawm lub teeb liab hla lub cev mus txog lub hom phiaj ntawm tes.
Paracrine yog dab tsi?
Paracrine signaling yog ib hom kev taw qhia ntawm tes uas tshwm sim ntawm cov hlwb uas nyob ze rau ib leeg. Cells tso tawm signaling molecules rau extracellular chaw. Tom qab ntawd lawv diffuse los ntawm qhov chaw thiab ncav cuag lub hom phiaj hlwb. Ligands khi nrog cov receptors ntawm lub hom phiaj hlwb. Paracrine signaling pab cov cell sib txuas lus nyob rau hauv luv luv. Nws tso cai rau cov hlwb los koom ua haujlwm hauv zos nrog lawv cov hlwb nyob sib ze.
Daim duab 01: Paracrine Signaling - Synapse Signaling
Nerve impulse kis ntawm ob lub neurons los ntawm ib lub synapse yog ib qho piv txwv rau paracrine signaling. Presynaptic neuron tso tawm cov neurotransmitters, uas yog cov cim qhia cov molecules lossis ligands. Neurotransmitters taug kev los ntawm synapse thiab ncav cuag thiab khi nrog cov receptors ntawm postsynaptic neuron thiab hloov lub teeb liab rau nws.
Ntxiv nrog rau cov tshuaj neurotransmitters, qhov loj hlob thiab cov kab mob qog ntshav yog paracrine signaling agents. Yog li, paracrine signaling plays lub luag haujlwm tseem ceeb hauv kev tsim cov ntaub so ntswg. Ntxiv mus, paracrine signaling muaj feem xyuam rau cov lus teb rau allergens, kho cov ntaub so ntswg, tsim cov caws pliav, thiab ntshav txhaws.
Juxtacrine yog dab tsi?
Juxtacrine signaling yog ib daim ntawv ntawm cell signaling uas tshwm sim ntawm cov hlwb uas nyob ib sab. Tsis zoo li hauv paracrine signaling, cov hlwb yuav tsum nyob ze rau ib leeg rau juxtacrine signaling. Hauv cov kab mob, juxtacrine signaling hais txog kev sib cuam tshuam los ntawm kev sib cuag ntawm cov cell ncaj qha. Nws yog ib qho tsim nyog los tso cov xovtooj ntawm tes ntawm lub ntsej muag ntawm cov xov tooj ntawm tes kom haum rau ntawm lub xov tooj ntawm tes uas tsim nyog. Yog li ntawd, ligand ntawm ib lub xovtooj ntawm tes khi nrog cov receptor ntawm lub cell tom ntej.
Daim duab 02: Juxtacrine Signaling
Muaj peb hom juxtacrine signaling. Hauv ib hom, cov protein ntawm ib lub xov tooj ntawm tes khi rau nws cov receptor nyob rau saum npoo ntawm lub cell uas nyob ib sab. Hauv hom thib ob, ib qho receptor ntawm ib lub xovtooj khi rau nws cov ligand ntawm extracellular matrix secreted los ntawm lwm lub cell. Hauv hom thib peb, cov teeb liab raug xa ncaj qha los ntawm cytoplasm ntawm ib lub xov tooj ntawm tes los ntawm cov kav dej me me rau hauv cytoplasm ntawm ib qho cell uas nyob ib sab. Gap junctions nyob rau hauv cov tsiaj thiab plasmodesma nyob rau hauv cov nroj tsuag yog koom nyob rau hauv juxtacrine signaling.
Dab tsi yog qhov zoo sib xws ntawm Paracrine thiab Juxtacrine?
- Paracrine thiab juxtacrine signaling yog ob hom kev taw qhia ntawm tes.
- Nyob rau hauv ob hom kev taw qhia ntawm tes, ligands khi nrog cov receptors ntawm lub cell txais.
- Ob leeg txhawb kev sib txuas lus ntawm cov hlwb.
Qhov txawv ntawm Paracrine thiab Juxtacrine yog dab tsi?
Paracrine signaling yuav tsum tso tawm cov cim qhia txog cov khoom siv mus rau qhov chaw ntxiv ntawm tes txhawm rau txhawm rau nthuav dav thiab ncav cuag lub xov tooj tau txais. Juxtacrine signaling tsis xav tau kev tso tawm thiab nthuav tawm ntawm cov cim qhia cov khoom siv hauv qhov chaw ntxiv. Nws tsuas yog xav tau kev sib cuag ncaj qha ntawm cov hlwb. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm paracrine thiab juxtacrine.
Hauv qab info-graphic piv ob qho tib si taw qhia thiab tabulates qhov sib txawv tseem ceeb ntawm paracrine thiab juxtacrine.
Summary – Paracrine vs Juxtacrine
Paracrine thiab juxtacrine signaling yog ob hom kev taw qhia ntawm tes. Paracrine signaling tshwm sim ntawm cov hlwb uas nyob ze rau ib leeg. Juxtacrine signaling tshwm sim ntawm cov hlwb uas nyob rau hauv ncaj qha los yog nyob ze rau ib leeg. Kev tso tawm cov cim qhia txog cov khoom siv mus rau qhov chaw extracellular thiab diffusion ntawm signaling molecules los ntawm qhov chaw ntawm lub xov tooj txais yuav tsum tau nyob rau hauv paracrine signaling. Tab sis, nyob rau hauv juxtacrine signaling, ligands ntawm lub cell nto khi nrog cov tsim nyog receptors nyob rau saum npoo ntawm lub txais cell. Yog li ntawd, qhov diffusion ntawm signaling molecules tsis tas yuav tsum tau nyob rau hauv juxtacrine signaling. Yog li, qhov no qhia txog qhov sib txawv ntawm paracrine thiab juxtacrine.
