Qhov sib txawv tseem ceeb ntawm endocrine thiab paracrine yog cov cim endocrine siv cov kab mob hauv lub cev los thauj cov ligands los ntawm cov ntshav mus rau cov hlwb nyob deb thaum lub teeb liab paracrine ua rau cov neeg nyob sib ze.
Cells feem ntau sib txuas lus los ntawm cov cim tshuaj. Cov cim qhia tshuaj no feem ntau yog cov protein uas zais los ntawm lub xovtooj ntawm tes thiab tso tawm mus rau qhov chaw ntxiv. Los ntawm qhov ntawd, lawv kis mus rau cov hlwb nyob sib ze. Cov lus lossis cov teeb liab nqa los ntawm ligand khiav los ntawm cov saw hlau ntawm cov xa xov chemical hauv ib lub xov tooj ntawm tes. Cell rau cell signaling feem ntau yuav kis tau cov teeb liab los ntawm ib tug xa xov tooj mus rau ib tug txais xov tooj. Muaj plaub yam tseem ceeb ntawm kev taw qhia tshuaj lom neeg thiab lawv yog paracrine signaling, endocrine signaling, autocrine signaling, thiab signaling los ntawm kev sib cuag ncaj qha.
Endocrine yog dab tsi?
Ib kab mob endocrine yog tsim los ntawm ntau lub qog uas tso cov tshuaj hormones. Cov tshuaj hormones no tso tawm ncaj qha rau hauv cov ntshav ncig thiab tswj cov kab mob nyob deb. Thaum cov hlwb xa cov teeb liab dhau mus ntev, lawv feem ntau siv cov hlab ntsha. Qhov kev taw qhia deb no yog hu ua endocrine signaling. Lub hypothalamus yog lub chaw tswj hwm neural rau kev ua haujlwm ntawm endocrine. Cov qog endocrine tseem ceeb ntawm tib neeg muaj xws li qog pituitary, caj pas pineal, thyroid caj pas, thiab qog adrenal. Glands teeb liab ib leeg nyob rau hauv ib qho axis, thiab nws yog hu ua hypothalamic-pituitary-adrenal axis. Muaj ob peb lwm yam kabmob xws li pob txha, ob lub raum, siab, lub plawv, thiab gonads, uas muaj cov haujlwm endocrine thib ob.
Daim duab 01: Endocrine System
Ib qho tshwj xeeb ntawm cov qog endocrine yog qhov tsis muaj ducts. Lawv yog cov vascular thiab muaj intracellular vacuoles khaws cov tshuaj hormones. Cov kab mob endocrine ua haujlwm los ntawm kev tawm tswv yim loops. Cov lus qhia tseem ceeb tshaj plaws yog kho los ntawm hypothalamus thiab pituitary. Lub hypothalamus thiab anterior pituitary ua lub luag haujlwm tseem ceeb hauv xov tooj ntawm tes vim lawv yog ib feem ntawm hypothalamic-pituitary-adrenal axis. Lub endocrine system tswj yuav luag tag nrho cov txheej txheem lom neeg hauv lub cev los ntawm kev xeeb tub mus rau hnub nyoog laus. Qhov no tseem cuam tshuam txog kev txhim kho ntawm lub hlwb thiab lub paj hlwb, cov metabolism, cov ntshav qab zib, thiab kev loj hlob thiab kev ua haujlwm ntawm kev ua me nyuam.
Paracrine yog dab tsi?
Paracrine signaling ua hauv zos ntawm cov hlwb uas nyob ze ib leeg. Cov teeb liab no txav los ntawm diffusion los ntawm extracellular matrix. Lawv nthuav tawm cov lus teb ceev tab sis tsuas yog siv sijhawm luv luv xwb. Txhawm rau khaws cov cim hauv zos, paracrine ligands raug degraded los ntawm enzymes los yog tshem tawm los ntawm cov hlwb nyob sib ze. Kev tshem tawm ntawm cov teeb liab rov tsim kho qhov concentration gradient rau cov teeb liab, tso cai rau lawv kom nrawm dua los ntawm qhov chaw intracellular. Kev hloov ntawm cov teeb liab hla lub synapse ntawm paj hlwb yog ib qho piv txwv ntawm paracrine signals.
Daim duab 02: Hom Kev Qhia Tawm
Cov kab mob sib txawv hauv lub cev siv cov tshuaj paracrine zoo sib xws uas tau faib ua plaub tsev neeg raws li lawv cov qauv. Lawv yog tsev neeg fibroblast loj hlob (FGF), tsev neeg Hedgehog, tsev neeg Wnt, thiab TGF-β superfamily. Kev khi ntawm ib qho paracrine yam tseem ceeb rau nws cov neeg txais kev pabcuam pib cov cim tshwj xeeb nrog cov lus teb sib txawv. Tsev neeg FGF muaj ntau yam haujlwm; Txawm li cas los xij, lawv txoj haujlwm tseem ceeb yog los txhawb kev loj hlob thiab kev sib txawv. Hedgehog tsev neeg koom nrog inducing cell hom thiab tsim cov ntaub so ntswg ciam teb, thiab patterning nyob rau hauv ob sab organisms. Wnt tsev neeg suav nrog ntau cov cysteine-nplua nuj glycoproteins. Lawv qhib cov teeb liab transduction cascades. TGF-β superfamily tswj txoj kev loj hlob ntawm lub embryo rau ib tug neeg laus kab mob los ntawm kev loj hlob ntawm tes, sib txawv, apoptosis, thiab homeostasis.
Dab tsi zoo sib xws ntawm Endocrine thiab Paracrine?
- Endocrine thiab paracrine yog hom kev taw qhia ntawm tes.
- Ob leeg muaj cov proteins.
- Lawv xa cov cim los ntawm ligands.
Qhov txawv ntawm Endocrine thiab Paracrine yog dab tsi?
Cov kab mob endocrine siv cov kab mob hauv lub cev los thauj cov ligands los ntawm cov ntshav mus rau cov hlwb nyob deb, thaum lub cim paracrine ua rau cov hlwb nyob sib ze. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm endocrine thiab paracrine. Cov tshuaj hormones hauv endocrine signaling feem ntau yog diluted thiab tam sim no nyob rau hauv qis concentration thaum ua rau lub hom phiaj hlwb, thaum nyob rau hauv paracrine signaling, concentration ntawm ligands yog heev. Ntxiv mus, cov lus teb nyob rau hauv endocrine signaling yog ceev, thaum paracrine signaling qhia ib tug qeeb teb.
Cov hauv qab no qhia txog qhov sib txawv ntawm endocrine thiab paracrine hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Endocrine vs Paracrine
Cells feem ntau sib txuas lus los ntawm cov cim tshuaj. Endocrine thiab paracrine yog ob hom kev taw qhia tshuaj. Endocrine signals siv cov hlab ntsha los thauj cov ligands los ntawm cov ntshav mus rau cov hlwb nyob deb. Ntawm qhov tod tes, paracrine signaling ua rau cov hlwb nyob sib ze. Cov kab mob endocrine yog tsim los ntawm ntau cov qog, uas tso cov tshuaj hormones. Cov tshuaj hormones no tso tawm ncaj qha rau hauv cov ntshav ncig thiab tswj cov kab mob nyob deb. Cov txheej txheem no hu ua endocrine signaling. Paracrine signals txav los ntawm diffusion los ntawm extracellular matrix. Cov kab mob endocrine ua rau cov lus teb qeeb qeeb, tab sis lawv muaj qhov cuam tshuam ntev, thaum cov kab mob paracrine feem ntau teb sai sai tab sis kav ntev rau lub sijhawm luv. Yog li, qhov no qhia txog qhov sib txawv ntawm endocrine thiab paracrine.
