Qhov sib txawv tseem ceeb ntawm Gilman thiab Grignard reagent yog Gilman reagent yog ib qho reagent ntawm tooj liab thiab lithium, whereas Grignard reagent yog reagent ntawm magnesium.
A reagent yog ib yam khoom uas peb tuaj yeem ntxiv rau cov tshuaj tiv thaiv sib xyaw kom ua rau muaj tshuaj lom neeg lossis sim tshuaj yog tias muaj tshuaj lom neeg tshwm sim hauv ib lub cev. Gilman reagent thiab Grignard reagent yog ob hom tshuaj.
Gilman Reagent yog dab tsi?
Gilman reagent yog ib qho reagent ntawm tooj liab thiab lithium hlau. Yog li ntawd, peb tuaj yeem hu nws ua cov tshuaj diorganocopper. Cov tshuaj formula ntawm cov tshuaj no yog R2CuLi. Hauv cov tshuaj no, R yog ib qho alkyl lossis aryl pawg. Cov reagent no muaj txiaj ntsig zoo vim tias tsis zoo li lwm cov hlau reagents, Gilman reagent tuaj yeem cuam tshuam nrog cov organic halides los hloov halide pawg nrog R pawg. Cov tshuaj tiv thaiv no muaj npe hu ua Corey-House cov tshuaj tiv thaiv. Cov kev hloov pauv no yog qhov tseem ceeb hauv kev sib xyaw ntawm cov khoom lag luam los ntawm cov tsev yooj yim.
Daim duab 01: Cov qauv dav dav ntawm Gilman Reagent
Cov tshuaj reagent no tau tshawb pom los ntawm tus kws tshawb fawb Henry Gilman thiab nws cov neeg ua haujlwm. Ib hom Gilman reagent yog Lithium dimethylcopper muaj cov tshuaj formula (CH3) 2CuLi. Peb tuaj yeem npaj cov reagent no los ntawm kev sib ntxiv ntawm tooj liab (I) iodide rau methyllithium nyob rau hauv lub xub ntiag ntawm tetrahydrofuran ntawm qhov kub thiab txias. Cov khoom ntawm cov tshuaj tiv thaiv no tshwm sim raws li ib tug dimer nyob rau hauv diethyl ether, tsim ib tug yim-ntiv nplhaib qauv.
Grignard Reagent yog dab tsi?
Lub Grignard reagent yog ib qho reagent uas muaj magnesium hlau. Cov tshuaj formula rau cov tshuaj no yog R-Mg-X. Hauv cov qauv no, R yog hais txog cov tshuaj organic, Mg hais txog magnesium, thiab X yog hais txog halogen. Feem ntau, pawg R hauv cov tshuaj no yog ib pawg alkyl lossis aryl pawg. Muaj ob qho piv txwv rau Grignard reagent; methylmagnesium chloride thiab phenylmagnesium bromide.
Hauv cov tshuaj tiv thaiv organic, Grignard reagents yog cov tshuaj nrov. Cov reagents no yuav pab tau tsim cov pa roj carbon-carbon tshiab. E.g. Nyob rau hauv cov tshuaj tiv thaiv ntawm halogenated compound R'-X' thiab Grignard reagent nyob rau hauv lub xub ntiag ntawm ib tug haum catalyst, cov khoom kawg yog R-R' thiab cov byproduct ntawm cov tshuaj tiv thaiv yog MgXX'.
Daim duab 02: Cov Lus Teb Ntawm Grignard Reagent thiab Carbonyl Compounds
Ntxiv mus, cov ntshiab Grignard reagents yog cov khoom muaj zog heev. Yog li ntawd, peb yuav tsum tuav cov tshuaj no raws li kev daws teeb meem hauv cov kuab tshuaj xws li diethyl ether lossis THF. Cov reagents no ruaj khov rau qee lub sijhawm yog tias cov dej tsis suav nrog cov tshuaj.
Qhov txawv ntawm Gilman thiab Grignard Reagent yog dab tsi?
Qhov sib txawv tseem ceeb ntawm Gilman thiab Grignard reagent yog tias Gilman reagent yog ib qho reagent ntawm tooj liab thiab lithium whereas Grignard reagent yog ib qho reagent ntawm magnesium. Tsis tas li ntawd, Gilman reagents tshwm sim nyob rau hauv cov kua hauv lub xeev thaum lub Grignard reagents, thaum ntshiab, tshwm sim nyob rau hauv lub solid-state.
Cov infographic hauv qab no qhia txog qhov sib txawv ntawm Gilman thiab Grignard reagent.
Summary – Gilman vs Grignard Reagent
A reagent yog ib yam khoom uas peb tuaj yeem ntxiv rau cov tshuaj tiv thaiv sib xyaw kom ua rau muaj tshuaj lom neeg lossis sim tshuaj yog tias muaj tshuaj lom neeg tshwm sim hauv ib lub cev. Qhov sib txawv tseem ceeb ntawm Gilman thiab Grignard reagent yog Gilman reagent yog ib qho reagent ntawm tooj liab thiab lithium whereas Grignard reagent yog ib qho reagent ntawm magnesium.
