Qhov sib txawv tseem ceeb ntawm LPS thiab LOS yog tias LPS muaj qhov hnyav molecular heev, qhov LOS muaj qhov hnyav molecular.
Ob leeg LPS thiab LOS yog cov kab mob lipopolysaccharides. Lo lus LPS sawv cev rau lipopolysaccharide thaum lub sij hawm LOS yog lipooligosaccharide. Peb tuaj yeem pom cov organic molecules nyob rau hauv daim nyias nyias ntawm cov kab mob gram-negative. Cov molecules no yog cov loj molecules uas muaj ib tug lipid tivthaiv thiab ib tug polysaccharide tivthaiv, ib tug txheej core thiab ib tug puab core uas tau koom ua ke nrog ib tug covalent daim ntawv cog lus.
LPS yog dab tsi?
LPS sawv cev rau lipopolysaccharides. Lawv kuj muaj npe li lipoglycans thiab endotoxins. Cov no yog cov molecules loj heev uas muaj qhov hnyav molecular. Ib qho LPS molecule muaj cov lipid tivthaiv thiab cov khoom siv polysaccharide uas muaj O-antigen, cov tub ntxhais sab nraud thiab cov tub ntxhais sab hauv. Cov tub ntxhais sab nraud thiab cov tub ntxhais sab hauv no tau khi rau ib leeg ntawm covalent tshuaj sib txuas. Peb tuaj yeem pom cov molecules hauv daim nyias nyias ntawm cov kab mob gram-negative.
Daim duab 01: Tus qauv ntawm LPS Molecule
Peb tuaj yeem pom LPS ua cov khoom tseem ceeb hauv cov kab mob sab nrauv, thiab nws tuaj yeem tiv thaiv daim nyias nyias los ntawm qee yam tshuaj tua kab mob. Ntxiv mus, LPS tuaj yeem ua rau kom tsis zoo ntawm cov cell membrane ntawm cov kab mob, thiab nws pab kom ruaj khov ntawm tag nrho cov membrane qauv. Yog tias cov qauv ntawm LPS hloov pauv lossis yog tias LPS raug tshem tawm ntawm lub cell membrane ntawm cov kab mob, nws tuaj yeem ua rau cov kab mob tuag. Txawm li cas los xij, peb tuaj yeem lees paub LPS tsis yog qhov tseem ceeb hauv qee cov kab mob gram-tsis zoo. LPS tuaj yeem cuam tshuam cov lus teb muaj zog los ntawm cov tsiaj tiv thaiv kab mob.
Daim duab 2: Kev sib xyaw ntawm LPS; core hauv xim liab, glucosamine residues xiav xim, thiab phosphate pawg hauv ntsuab xim
LOS yog dab tsi?
Lo lus LOS yog lipooligosaccharide. Cov no yog glycolipids peb tuaj yeem pom hauv daim nyias nyias ntawm qee hom kab mob gram-tsis zoo. E.g. Neisseria swb. Nws yog cov kab mob qis molecular hnyav LPS. Cov tshuaj no ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ncaj ncees thiab kev ua haujlwm ntawm cov txheej txheem ntawm lub hnab ntawv gram-negative cell. Ntxiv mus, cov molecules no tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tsim cov kab mob ntawm qee yam kab mob vim tias lawv tuaj yeem ua raws li immunostimulators thiab immunomodulators. Tsis tas li ntawd, cov molecules no yog lub luag haujlwm rau lub peev xwm ntawm qee cov kab mob los tso saib cov molecular mimicry thiab antigenic ntau haiv neeg. Qhov no pab rau kev khiav tawm ntawm tus tswv tsev tiv thaiv kab mob thiab yog li ua rau muaj kev phom sij ntawm cov kab mob no.
Qhov txawv ntawm LPS thiab LOS yog dab tsi?
LPS thiab LOS yog cov roj ntsha molecules uas tuaj yeem pom nyob rau hauv daim nyias nyias ntawm cov kab mob gram-tsis zoo. Lo lus LPS sawv cev rau lipopolysaccharide thaum lub sij hawm LOS yog lipooligosaccharide. Qhov sib txawv tseem ceeb ntawm LPS thiab LOS yog tias LPS muaj qhov hnyav molecular hnyav, qhov LOS muaj qhov hnyav molecular.
Ntxiv mus, LPS muaj ntau cov glucosamine residues, core, thiab phosphate pawg, thaum LOS muaj ib qho me me ntawm glucosamine, core thiab phosphate pawg.
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv ntawm LPS thiab LOS hauv daim ntawv teev npe.
Summary – LPS vs LOS
LPS thiab LOS yog cov roj ntsha molecules uas tuaj yeem pom nyob rau hauv daim nyias nyias ntawm cov kab mob gram-tsis zoo. Lo lus LPS sawv cev rau lipopolysaccharide. Lo lus LOS yog lipooligosaccharide. Hauv cov ntsiab lus, qhov sib txawv tseem ceeb ntawm LPS thiab LOS yog tias LPS muaj qhov hnyav heev molecular, qhov LOS muaj qhov hnyav molecular.
