Qhov sib txawv tseem ceeb ntawm basophilic stippling thiab pappenheimer lub cev yog tias cov granules hauv basophilic stippling tsis muaj hlau thaum pappenheimer lub cev muaj hlau thiab lawv stain nrog Prussian xiav.
Erythrocyte suav nrog yog tshwm sim los ntawm ntau hom ntshav ntshav thiab lwm yam mob. Basophilic stippling thiab pappenheimer lub cev yog ob qho piv txwv ntawm ntau qhov chaw kho mob tseem ceeb erythrocyte suav nrog. Basophilic stippling yog muaj ntau basophilic granules nyob rau hauv cytoplasm ntawm erythrocytes. Pappenheimer lub cev kuj yog erythrocyte granules uas muaj hlau.
Basophilic Stippling yog dab tsi?
Basophilic stippling yog muaj ntau basophilic granules nyob rau hauv cytoplasm ntawm erythrocytes. Nws tseem hu ua punctate basophilia. Nws yog ib qho kev tshwm sim ntau zaus ntawm cov kab mob hematologic hauv cov ntshav peripheral. Qhov tseeb, nws yog tshwm sim los ntawm kev cuam tshuam erythrocyte txheej txheem los yog cuam tshuam erythropoiesis thiab erythrocyte maturation. Cov basophilic granules yog RNA residues uas muaj aggregates ntawm ribosomes, degenerating mitochondria thiab siderosomes. Txawm li cas los xij, tsis zoo li pappenheimer lub cev, granules tsis muaj hlau. Li no, lawv tsis zoo nrog Perls' acid ferrocyanide stain rau hlau.
Daim duab 01: Basophilic Stippling
Nyob rau hauv tshuaj lom tshuaj lom neeg, basophilic stippling tuaj yeem pom. Hauv kev lom tshuaj lom, RNase lossis ribonuclease tsis degrade ribosomes. Yog li, tsis tiav lossis tsis ua tiav ntawm ribosomal degradation ua rau nag lossis daus ntawm ribosomes lossis ribosomal seem nyob rau hauv circulating erythrocytes, ua rau basophilic stippling. Sib nrug los ntawm cov hlau lead, basophilic stippling tuaj yeem yog qhov qhia txog ntau yam hnyav hlau toxicities. Ntxiv mus, basophilic stippling yog txuam nrog Thalassemia, Hemolytic anemia, megaloblastic anemia, myelodysplastic syndrome.
Pappenheimer Lub Cev yog dab tsi?
Pappenheimer lub cev yog ib hom erythrocyte suav nrog uas muaj hlau. Lawv yog cov khib nyiab me me lossis cov granules uas muaj hlau uas feem ntau raug rhuav tshem ua ntej erythrocytes nkag mus rau hauv cov hlab ntsha hauv cov neeg noj qab haus huv nrog tus po ib txwm. Yog li, pappenheimer lub cev tau pom hauv cov neeg mob uas tsis muaj tus po (post-splenectomy),. Ntxiv mus, pappenheimer lub cev tuaj yeem pom hauv cov neeg mob uas muaj mob ntshav qab zib mellitus, myelodysplastic syndrome (MDS), congenital dyserythropoietic anemia thiab thalassemia.
Daim duab 02: Pappenheimer Lub cev
Prussian xiav (hlau stain) tuaj yeem paub meej tias muaj lub cev pappenheimer hauv peb cov ntshav peripheral smear. Lawv tshwm raws li me me xiav granular thiab irregularly zoo li inclusions. Wright-Giemsa stained blood smear kuj tuaj yeem pom lub cev pappenheimer.
Dab tsi yog qhov zoo sib xws ntawm Basophilic Stippling thiab Pappenheimer Lub Cev?
- Erythrocytes muaj basophilic granules nyob rau hauv ob qho tib si basophilic stippling thiab pappenheimer lub cev.
- Ob leeg yog erythrocyte inclusions.
- Cov aggregates precipitate hauv cytoplasm ntawm erythrocytes.
- Ob leeg tuaj yeem kuaj tau hauv cov ntshav peripheral smears.
- Lead toxins thiab thalassemia yog ib qho laj thawj rau ob qho tib si suav nrog.
Qhov txawv ntawm Basophilic Stippling thiab Pappenheimer Lub Cev yog dab tsi?
Basophilic stippling yog qhov muaj ntau basophilic granules thoob plaws hauv cytoplasm ntawm erythrocytes hauv cov ntshav peripheral smear. Pappenheimer lub cev, ntawm qhov tod tes, yog qhov txawv txav basophilic granules ntawm hlau pom hauv cov qe ntshav liab. Basophilic granules hauv basophilic stippling tsis muaj hlau thaum lub cev pappenheimer muaj hlau. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm basophilic stippling thiab pappenheimer lub cev.
Basophilic stippling qhia pom qhov tsis zoo rau Perls' acid ferrocyanide stain test, thaum lub cev pappenheimer qhia tau zoo. Erythrocyte inclusions ntawm basophilic stippling yog aggregates ntawm ribosomes thiab fragments ntawm ribosomal RNA / ribonuclear proteins thaum pappenheimer lub cev yog ferritin aggregates, los yog mitochondria los yog phagosomes uas muaj aggregated ferritin. Yog li, qhov no kuj yog qhov sib txawv ntawm basophilic stippling thiab pappenheimer lub cev.
Cov hauv qab no qhia txog qhov sib txawv ntawm basophilic stippling thiab pappenheimer lub cev.
Summary – Basophilic Stippling vs Pappenheimer Lub cev
Basophilic stippling yog muaj ntau cov basophilic granules faib los ntawm cytoplasm ntawm erythrocytes. Cov granules no yeej ib txwm sib sau ua ke ntawm ribosomes thiab fragments ntawm ribosomal RNA / ribonuclear proteins. Ntawm qhov tod tes, pappenheimer lub cev yog basophilic granules uas muaj hlau. Lawv feem ntau yog ferritin aggregates, lossis mitochondria lossis phagosomes uas muaj cov ferritin sib xyaw. Qhov sib txawv tseem ceeb ntawm basophilic stippling thiab pappenheimer lub cev yog tias basophilic granules tsim nyob rau hauv basophilic stippling tsis muaj hlau thaum lub cev pappenheimer muaj hlau.
