Qhov sib txawv tseem ceeb ntawm TATA thiab CAAT lub thawv yog tias TATA lub thawv yog thaj chaw khaws cia nucleotide uas muaj qhov kev pom zoo ntawm TATAWAW thaum lub thawv CAAT yog thaj chaw khaws cia nucleotide nrog qhov kev pom zoo ntawm GGCCCAATCT.
TATA lub thawv thiab CAAT lub thawv yog ob thaj chaw ntawm nucleotides uas cuam tshuam rau kev hloov pauv ntawm cov noob eukaryotic. Lawv yog cov tsis-coding DNA sequences pom nyob rau hauv lub transcription pib qhov chaw. Qhov tseeb, lawv pom nyob rau hauv cheeb tsam tswj hwm, uas yog hu ua tus txhawb nqa. Ob lub thawv TATA thiab CAAT lub thawv yog lub luag haujlwm rau kev ua haujlwm ntawm kev sau ntawv. Lawv yog cov kev pom zoo ua ntu zus uas tsis tau hloov pauv thoob plaws hauv cov txheej txheem evolutionary.
TATA Box yog dab tsi?
TATA lub thawv lossis lub thawv Goldberg-Hogness yog qhov kev pom zoo ib ntus pom nyob hauv thaj tsam txhawb nqa ntawm cov noob caj noob ces eukaryotic. TATA lub thawv yog lub hauv paus tseem ceeb ntawm tus txhawb nqa. Nws yog nyob rau hauv 25 lub hauv paus khub upstream ntawm qhov chaw pib transcription. Nws yog khaws cia thoob plaws hauv cov txheej txheem evolutionary. Qhov kev pom zoo ua ntu zus ntawm TATA lub thawv yog TATAWAW, qhov twg W yog A lossis T. Nws yog qhov tsis yog-coding DNA ntu. Txawm li cas los xij, TATA lub thawv yog qhov tseem ceeb rau kev hloov pauv ntawm cov noob. Nws yog qhov chaw khi ntawm TATA-binding protein (TBP) thiab lwm yam kev hloov pauv. Thaum lawv khi rau hauv lub thawv TATA, kev nrhiav neeg ua haujlwm ntawm RNA polymerase II thiab kev tswj xyuas kom zoo ntawm kev sau ntawv yuav tshwm sim hauv cov noob eukaryotic.
Daim duab 01: TATA Box
Vim TATA lub thawv koom nrog kev tswj hwm ntawm kev hloov pauv, kev hloov pauv ntawm TATA lub thawv tuaj yeem ua rau muaj kev hloov pauv phenotypic ua rau cov kab mob xws li mob plab, spinocerebellar ataxia, Huntington's kab mob, dig muag, β-thalassemia, kev tiv thaiv kab mob, Gilbert's syndrome, thiab HIV-1, thiab lwm yam.
CAAT Box yog dab tsi?
CAAT lub thawv yog thaj tsam ntawm nucleotides nrog qhov kev pom zoo ntawm GGCCAATCT. Zoo ib yam li TATA lub thawv, CAAT lub thawv tseem nyob hauv thaj tsam txhawb nqa ntawm cov noob. Yog li ntawd, nws nyob li ntawm 75-80 lub hauv paus khub nce mus rau qhov chaw sau npe.
Daim duab 02: CAAT Box
Txoj kev hloov pauv tshwj xeeb khi rau lub thawv CAAT. Qhov kev khi no ruaj khov rau qhov ua ntej ua ntej kom yooj yim khi ntawm enzyme RNA polymerase. Ib yam li ntawd, CAAT lub thawv ua haujlwm raws li kev tswj hwm ib ntus. Kev hloov pauv hauv cheeb tsam CAAT lub thawv muaj feem cuam tshuam rau kev txhawb nqa cov lus teb thiab kev tswj hwm ntawm kev sau ntawv.
Qhov Zoo sib xws ntawm TATA thiab CAAT Box yog dab tsi?
- TATA thiab CAAT yog ob thaj chaw ntawm nucleotides pom nyob rau hauv cov txheej txheem tswj hwm ntawm cov noob eukaryotic.
- Lawv tau pom ntws mus rau qhov chaw pib sau npe.
- Ob leeg yog kev pom zoo DNA ib ntus.
- Lawv yog qhov tseem ceeb rau txoj cai ntawm kev sau ntawv, yog li lawv yog cov kev cai ua ntu zus.
Qhov txawv ntawm TATA thiab CAAT Box yog dab tsi?
TATA lub thawv yog thaj chaw khaws cia nucleotide pom txog 25-30 lub hauv paus khub nce mus rau qhov chaw pib pib. Ntawm qhov tod tes, CAAT lub thawv yog thaj chaw khaws cia ntawm nucleotides pom txog 75-80 lub hauv paus khub nce mus rau qhov chaw pib pib. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm TATA thiab CAAT lub thawv. Dhau li ntawd, TATA lub thawv muaj qhov kev pom zoo ntawm TATAWAW thaum GGCCAATCT yog qhov kev pom zoo ntawm CAAT lub thawv.
Ntxiv mus, lwm qhov sib txawv tseem ceeb ntawm TATA thiab CAAT lub thawv yog tias TATA lub thawv muab qhov chaw sib khi rau TBP thiab cov ntaub ntawv hloov pauv thiab koom nrog kev tswj hwm kev hloov pauv thaum lub thawv CAAT qhia qhov chaw sib khi rau RNA qhov kev hloov pauv.
Hauv qab infographic qhia txog qhov sib txawv ntawm TATA thiab CAAT lub thawv.
Summary – TATA vs CAAT Box
TATA lub thawv thiab CAAT lub thawv yog ob feem ntawm thaj chaw khaws cia ntawm eukaryotic gene promoters. Lawv nyob rau sab sauv mus rau qhov chaw pib transcription. Ob qho tib si cuam tshuam rau kev hloov pauv ntawm cov noob los ntawm kev muab cov chaw rau kev khi TATA-binding proteins thiab cov txheej txheem pib pib. TATA lub thawv nyob ntawm 25-35 lub hauv paus khub ntawm qhov chaw pib hloov pauv thaum lub thawv CAAT nyob ntawm 75-80 lub hauv paus khub nce mus rau qhov chaw pib hloov pauv. Qhov kev pom zoo ua ntu zus ntawm TATA lub thawv yog TATAWAW thaum qhov kev pom zoo ntawm CAAT lub thawv yog GGCCAATCT. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm TATA thiab CAAT lub thawv.
