Qhov sib txawv tseem ceeb ntawm proteoglycans thiab glycosaminoglycans yog tias proteoglycans yog cov organic tebchaw uas muaj protein ntau khi rau mucopolysaccharide whereas glycosaminoglycans yog mucopolysaccharides uas muaj ib tug xov tooj ntawm disaccharide repeating units.
Proteoglycans thiab glycosaminoglycans yog cov tshuaj biochemical uas tuaj yeem pom hauv peb lub cev. Cov no yog cov tebchaw loj heev uas muaj ntau cov atoms ib lub molecule.
YProteoglycans yog dab tsi?
Proteoglycans yog cov khoom sib xyaw uas muaj cov protein thiab mucopolysaccharide ua ke nrog ib leeg. Yog li, cov tebchaw no muaj npe ua cov proteins, thiab lawv muaj glycosylated heev. Cov protein nyob hauv cov molecule no hu ua "core protein". Feem ntau, cov core protein muaj ib lossis ntau dua glycosaminoglycan units txuas rau nws. Qhov kev txuas no yog covalent daim ntawv cog lus, thiab nws tshwm sim los ntawm serine residue. Ntawm no, ib qho glycosaminoglycan txuas los ntawm tus choj tetrasaccharide (plaub monosaccharide units tsim tus choj). Cov glycosaminoglycan molecules tshwm sim raws li ntev, linear polymer chains. Tsis tas li ntawd, cov saw hlau polymer no yog cov tshuaj tsis zoo vim muaj cov sulfate thiab uronic acid pawg. Feem ntau, peb tuaj yeem soj ntsuam pom muaj cov proteoglycans hauv cov ntaub so ntswg ntawm tib neeg lub cev.
Daim duab 01: Protein Structure
Tsis tas li ntawd, proteoglycans tuaj yeem raug cais raws li hom glycosaminoglycan tam sim no hauv cov molecule thiab qhov loj ntawm proteoglycan. Piv txwv li, muaj cov proteoglycans me thiab loj thaum lawv categorized nyob ntawm qhov loj ntawm cov molecule thiab qee cov chav kawm ntawm proteoglycan cais raws li glycosaminoglycan muaj xws li keratin sulfate, chondroitin sulfate, dermatan sulfate, thiab lwm yam.
Thaum xav txog kev ua haujlwm ntawm proteoglycans hauv tib neeg lub cev, peb tuaj yeem pom lawv ua cov khoom tseem ceeb hauv cov tsiaj txhu extracellular matrix. Thiab, lawv tsim cov pob txha mos thaum sib xyaw nrog collagen thiab koom nrog hauv kev khi cations thiab dej nrog cov hlwb.
Glycosaminoglycans yog dab tsi?
Glycosaminoglycans yog ib hom mucopolysaccharide uas muaj ntau cov disaccharide units ua ke nrog ib leeg nyob rau hauv ib tug linear qauv. Feem ntau, cov chav rov ua dua no muaj cov suab thaj amino, uronic qab zib, thiab galactose (tshwj tsis yog keratin). Glycosaminoglycans yog ib qho tseem ceeb nyob rau hauv tib neeg lub cev raws li lubricants thiab shock absorbers.
Daim duab 02: Disaccharide Repeating Unit
Vim tias kev tsim cov glycosaminoglycans tsis yog tswj hwm los ntawm tus qauv raws li cov proteins, cov molecules no sib txawv heev hauv kev tsim cov khoom siv disaccharide thiab sulfation. Cov txheej txheem ntau lawm yog hloov pauv tas li los ntawm kev ua enzyme. Peb tuaj yeem faib cov glycosaminoglycans ua plaub pawg loj xws li heparin, dermatan sulfate, keratan sulfate, thiab hyaluronic acid.
Thaum xav txog kev ua haujlwm ntawm glycosaminoglycans, lawv tseem ceeb hauv kev cuam tshuam nrog heparin-binding proteins rau kho qhov txhab, tu cov ntaub so ntswg hydration, khi hlwb ua ke (hyaluronic acid), lubricating pob qij txha, pab tswj cov duab ntawm lub qhov muag, thiab lwm yam..
Qhov txawv ntawm Proteoglycans thiab Glycosaminoglycans yog dab tsi?
Proteoglycans thiab glycosaminoglycans yog cov tshuaj biochemical uas tuaj yeem pom hauv peb lub cev. Cov no yog cov tebchaw loj heev uas muaj ntau cov atoms ib lub molecule. Qhov sib txawv tseem ceeb ntawm proteoglycans thiab glycosaminoglycans yog tias proteoglycans yog cov organic tebchaw uas muaj protein ntau khi rau mucopolysaccharide hos glycosaminoglycans yog mucopolysaccharides uas muaj ib tug xov tooj ntawm disaccharide repeating units.
Ntxiv mus, lwm qhov sib txawv tseem ceeb ntawm proteoglycans thiab glycosaminoglycans yog lawv txoj haujlwm. Cov proteoglycans yog cov khoom tseem ceeb hauv tus tsiaj lub cev matrix. Thiab, lawv tsim cov pob txha mos thaum ua ke nrog collagen thiab koom nrog hauv kev khi cations thiab dej nrog cov hlwb. Lub caij no, glycosaminoglycans tseem ceeb hauv kev cuam tshuam nrog heparin-binding proteins rau kho qhov txhab, kho cov ntaub so ntswg hydration, khi hlwb ua ke (hyaluronic acid), lubricating pob qij txha, pab tswj cov duab ntawm lub qhov muag, thiab lwm yam.
Hauv qab infographic tabulates qhov sib txawv ntawm proteoglycans thiab glycosaminoglycans.
Summary – Proteoglycans vs Glycosaminoglycans
Proteoglycans thiab glycosaminoglycans yog cov tshuaj biochemical uas tuaj yeem pom hauv peb lub cev. Cov no yog cov tebchaw loj heev uas muaj ntau cov atoms ib molecule. Qhov sib txawv tseem ceeb ntawm proteoglycans thiab glycosaminoglycans yog tias proteoglycans yog cov organic tebchaw uas muaj protein ntau khi rau mucopolysaccharide hos glycosaminoglycans yog mucopolysaccharides uas muaj ib tug xov tooj ntawm disaccharide repeating units.
