Qhov sib txawv tseem ceeb ntawm cov proteoglycans thiab glycoproteins yog tias cov proteoglycans muaj cov hlua txuas ntev nrog cov disaccharide units ua cov qauv rov ua dua thaum cov glycoproteins muaj luv luv glycan chains uas tsis muaj rov ua dua.
Glycoproteins thiab proteoglycans yog ob hom molecules uas muaj cov proteins thiab carbohydrate units. Cov carbohydrate units tau khi covalently rau cov proteins molecules, sib txawv ntawm qhov loj ntawm monosaccharides mus rau polysaccharides.
YProteoglycans yog dab tsi?
Proteoglycans yog tsim los ntawm cov tub ntxhais protein nrog ib los yog ntau dua covalently txuas glycosaminoglycan (GAG) chains. Cov ntaub so ntswg sib txuas muaj pProteoglycans, thiab lawv pab txhawb rau lub koom haum thiab lub cev lub cev ntawm cov khoom siv ntxiv. Raws li qhov xwm txheej ntawm cov saw glycosaminoglycan, proteoglycans tuaj yeem muab faib ua ntau pawg, suav nrog chondroitin sulfate / demean sulfate, heparin sulfate, chondroitin sulfate, thiab keratan sulfate. Proteoglycans kuj tuaj yeem muab faib raws li lawv qhov loj me thiab loj proteoglycans.
Daim duab 01: Extracellular Matrix Cheebtsam ntawm pob txha mos
YGlycoproteins yog dab tsi?
Glycoproteins yog cov proteins uas cov carbohydrates yog covalently khi los ntawm glycosidic bonds. Glycoproteins feem ntau pom nyob rau hauv lub cev thiab yog ib feem tseem ceeb ntawm daim nyias nyias thiab Golgi apparatus hauv hlwb. Ntxiv rau qhov ntawd, lawv kuj ua haujlwm raws li kev paub txog cellular molecules xws li receptors, adhesion molecules, thiab lwm yam.
Daim duab 02: Glycoproteins hauv Cell Membrane
Ob hom glycosylation yog N-glycosylation thiab O-glycosylation. Cov ntsiab lus carbohydrates hauv tib neeg glycoproteins yog qabzib, mannose, fucose, acetylgalactosamine, acetylglucosamine, acetyleuraminic acid, thiab xylose. Qee cov tshuaj hormones kuj suav tias yog glycoproteins, piv txwv li; FSH, LH, TSH, EPO, etc.
Qhov txawv ntawm Proteoglycans thiab Glycoproteins yog dab tsi?
Proteoglycans yog suav tias yog ib pawg ntawm glycoproteins. Qhov sib txawv tseem ceeb ntawm proteoglycans thiab glycoproteins yog tias glycoproteins muaj luv heev ceg glycan chains uas tsis muaj rov qab units thaum lub proteoglycans muaj ntev unbranched chains nrog disaccharide units raws li rov ua qauv. Ntxiv mus, cov ntsiab lus carbohydrate ntawm proteoglycans yog kwv yees li 10 - 15%, thaum glycoproteins yog 50 - 60% los ntawm qhov hnyav.
Tsis tas li ntawd, cov glycoproteins feem ntau pom nyob rau hauv cov cellular membrane ntawm cov hlwb thaum cov proteoglycans pom nyob rau hauv cov ntaub so ntswg sib txuas. Hais txog kev ua haujlwm, qhov sib txawv ntawm proteoglycans thiab glycoproteins yog tias cov proteoglycans yog qhov tseem ceeb hauv kev hloov pauv ntawm cov txheej txheem kev loj hlob ntawm tes, whereas glycoproteins ua haujlwm hauv cellular paub.
Cov hauv qab no infographic tabulates qhov sib txawv ntawm proteoglycans thiab glycoproteins rau ib sab ntawm kev sib piv.
Summary – Proteoglycans vs Glycoproteins
Glycoproteins thiab proteoglycans yog ob hom molecules uas muaj cov proteins thiab carbohydrate units. Proteoglycans raug suav hais tias yog ib pawg ntawm glycoproteins. Glycoproteins muaj luv luv glycan chains uas tsis muaj rov ua dua tshiab thaum proteoglycans muaj cov saw ntev ntev nrog cov disaccharide units ua cov qauv rov ua dua. Ntxiv mus, cov ntsiab lus carbohydrate ntawm proteoglycans yog li 10 - 15%, thaum cov ntsiab lus carbohydrate ntawm glycoproteins yog 50 - 60% los ntawm qhov hnyav. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm proteoglycans thiab glycoproteins.
Image Courtesy:
1. "Extracellular Matrix Cheebtsam ntawm pob txha mos" Los ntawm Kassidy Veasaw - Tus kheej ua haujlwm (CC BY-SA 4.0) ntawm Commons Wikimedia
2. "0303 Lipid Bilayer Nrog Ntau Yam" Los ntawm OpenStax - (CC BY 4.0) ntawm Commons Wikimedia
