Qhov sib txawv tseem ceeb ntawm mastocytosis thiab MCAS yog mastocytosis yog ib yam mob tshwm sim los ntawm ntau cov mast hlwb sib sau ua ke nyob rau hauv cov ntaub so ntswg ntawm lub cev, thaum MCAS yog ib tug mob uas mast hlwb nyob rau hauv lub cev tso tawm tsis tsim nyog. Cov tshuaj lom neeg rau hauv lub cev.
Mastocytosis thiab MCAS yog ob hom kab mob mast cell sib txawv. Cov kab mob mast cell yog cov mob tsis tshua muaj. Cov neeg uas muaj kab mob mast cell yuav hnov qhov tsis tau piav qhia, mob plab, tsam plab, tshwm sim hnyav rau zaub mov, tshuaj, lossis kab kab. Cov neeg no yuav hnov qhov kub txawm tias nyob hauv ib chav nrog qhov kub thiab txias. Cov tsos mob no tseem tuaj yeem qhia tias muaj kev tsis haum tshuaj.
Y Mastocytosis yog dab tsi?
Mastocytosis yog ib yam mob uas tshwm sim los ntawm ntau cov mast hlwb sib sau ua ke hauv cov ntaub so ntswg ntawm lub cev. Muaj ob hom mastocytosis: cutaneous mastocytosis thiab systematic mastocytosis. Cutaneous mastocytosis feem ntau cuam tshuam rau menyuam yaus. Nyob rau hauv cutaneous mastocytosis, mast hlwb sib sau ua ke nyob rau hauv daim tawv nqaij, tab sis tsis pom nyob rau hauv loj lwm qhov chaw ntawm lub cev. Ntawm qhov tod tes, systematic mastocytosis feem ntau cuam tshuam rau cov neeg laus. Nyob rau hauv lub cev mastocytosis, mast hlwb sib sau ua ke nyob rau hauv lub cev nqaij daim tawv, nrog rau cov tawv nqaij, sab hauv, thiab pob txha.
Daim duab 01: Mastocytosis
Cov tsos mob ntawm cov nqaij mos mastocytosis muaj xws li kev loj hlob txawv txav (qhov txhab) ntawm daim tawv nqaij xws li pob, pob, lossis pob khaus. Cov tsos mob ntawm cov kab mob mastocytosis muaj xws li dej ntws, khaus, khaus, mob plab, raws plab, xeev siab, ntuav, anemia, los ntshav, mob pob txha thiab cov leeg, mob siab, spleen, los yog qog nqaij hlav, kev nyuaj siab, kev xav hloov, lossis teeb meem hauv kev xav. Cov neeg uas muaj mastocytosis kuj muaj kev pheej hmoo ntawm kev tsim cov tshuaj tiv thaiv kab mob hnyav hu ua anaphylaxis.
Qhov ua rau mastocytosis yog KIT gene mutation, uas ua rau mast hlwb rhiab heev rau cov teebmeem ntawm cov signaling protein hu ua qia cell factor (SCF). SCF ua lub luag haujlwm txhawb kev tsim khoom thiab muaj sia nyob ntawm mast hlwb hauv cov pob txha pob txha. Ntxiv mus, tus mob no tuaj yeem kuaj tau los ntawm kev kuaj tawv nqaij, kuaj ntshav, ultrasound, DEXA scans los ntsuas cov pob txha ntom ntom, thiab kuaj pob txha pob txha. Tsis tas li ntawd, mastocytosis tuaj yeem kho nrog cov tshuaj steroid, tshuaj tiv thaiv kab mob, epinephrine, lwm yam tshuaj (ua raws plab thiab mob plab), thiab lub teeb ultraviolet.
MCAS (Mast Cell Activation Syndrome) yog dab tsi?
MCAS (mast cell activation syndrome) yog ib yam mob uas mast hlwb hauv lub cev tso cov tshuaj tsis tsim nyog rau hauv lub cev. Tus kab mob no yuav ua rau muaj kev tsis haum tshuaj hnyav thiab lwm yam tsos mob. MCAS feem ntau yog idiopathic. Tab sis MCAS tuaj yeem tshwm sim vim muaj kev hloov pauv caj ces xws li kev hloov pauv ntawm somatic hauv KIT, MC tswj cov noob caj noob ces, thiab tau txais ntau daim ntawv luam ntawm TPSAB1 noob.
Figure 02: MCAS
Cov tsos mob ntawm tus mob no muaj xws li khaus, tawm, khaus, khaus khaus, khaus khaus, khaus khaus, khaus khaus, khaus khaus, kiv taub hau, presyncope, syncope, arrhythmia, tachycardia, raws plab, xeev siab, ntuav, cramping, plab hnyuv tsis xis nyob, cem quav, nqos nyuaj, caj pas nruj, congestion, hnoos, hawb pob, thiab anaphylaxis. Qhov mob no feem ntau yog kuaj los ntawm kev kuaj ntshav rau qib mast cell tryptase thiab kuaj zis rau qib N-methylhistamine, 11B-prostaglandin F2 α, lossis leukotriene E4. Tsis tas li ntawd, kev kho mob rau MCAS suav nrog H1 thiab H2 tshuaj tiv thaiv kab mob, tshuaj aspirin, mast cell stabilizers, antileukotrienes, thiab corticosteroids.
Qhov Zoo sib xws ntawm Mastocytosis thiab MCAS yog dab tsi?
- Mastocytosis thiab MCAS yog ob hom kab mob mast cell.
- Ob leeg yog yam tsis tshua muaj.
- Cov tshuaj tsis haum hnyav xws li anaphylaxis tuaj yeem tshwm sim hauv ob qho xwm txheej.
- Ob qho xwm txheej no kho tau nrog tshuaj tiv thaiv.
Qhov txawv ntawm Mastocytosis thiab MCAS yog dab tsi?
Mastocytosis yog ib yam mob tshwm sim los ntawm ntau tshaj ntawm mast hlwb sib sau ua ke nyob rau hauv cov ntaub so ntswg ntawm lub cev, thaum MCAS (mast cell activation syndrome) yog ib tug mob uas mast hlwb nyob rau hauv lub cev tso ib tug tsis tsim nyog cov tshuaj mus rau hauv. lub cev. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm mastocytosis thiab MCAS. Tsis tas li ntawd, tus kab mob tshwm sim ntawm mastocytosis yog 5-10 rau 1,000,000 tus neeg, thaum tus kab mob tshwm sim ntawm MCAS yog 2.7 rau 1,000,000 tus neeg.
Cov duab hauv qab no nthuav tawm qhov sib txawv ntawm mastocytosis thiab MCAS hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Mastocytosis vs MCAS
Peb hom kab mob mast cell yog mastocytosis, mast cell activation syndrome (MCAS), thiab alpha tryptasemia (HAT). Mastocytosis yog ib yam mob uas tshwm sim los ntawm ntau cov mast hlwb sib sau ua ke hauv cov ntaub so ntswg ntawm lub cev, thaum MCAS (mast cell activation syndrome) yog ib yam mob uas mast hlwb hauv lub cev tso cov tshuaj tsis tsim nyog rau hauv lub cev.. Yog li, qhov no qhia txog qhov sib txawv ntawm mastocytosis thiab MCAS.
