Qhov sib txawv tseem ceeb ntawm quinoline thiab isoquinoline yog nyob rau hauv quinolone, nitrogen atom yog nyob rau hauv thawj txoj hauj lwm ntawm lub nplhaib qauv whereas, nyob rau hauv isoquinoline, nitrogen atom nyob rau hauv lub thib ob txoj hauj lwm ntawm lub nplhaib qauv.
Isoquinoline yog tus qauv isomer ntawm quinolone. Qhov no txhais tau hais tias ob lub tebchaw no muaj tib cov tshuaj formula tab sis sib txawv ntawm cov atoms. Tshwj xeeb, txoj haujlwm ntawm nitrogen atom hauv lub nplhaib qauv sib txawv hauv ob lub tebchaw.
YQuinoline yog dab tsi?
Quinolone yog cov organic compound nrog cov qauv heterocyclic aromatic nplhaib uas muaj cov tshuaj formula C9H7N. Nws yog me ntsis yellowish, oily kua. Cov kua no muaj ntxhiab tsw, thiab nws yog hygroscopic heev nyob rau hauv cov xwm. Thaum raug huab cua, cov kua no ua daj thiab tom qab ntawd tig xim av.
Daim duab 01: Cov Qauv Tshuaj ntawm Quinolone
Thaum xav txog cov tshuaj thiab lub cev ntawm quinolone, nws yog me ntsis soluble hauv dej txias tab sis yooj yim yaj hauv dej kub thiab feem ntau lwm cov kuab tshuaj organic. E.g. cawv, ether, carbon disulfide, thiab lwm yam.
Quinolone yog thawj zaug muab rho tawm los ntawm thee tar, thiab thee tar tseem yog qhov tseem ceeb ntawm quinolone. Peb tuaj yeem tsim cov quinolone siv cov tshuaj aniline yooj yim. Muaj ntau txoj hauv kev rau qhov kev sib txuas no, suav nrog combes quinolone synthesis, Conrad-Limpach synthesis, Doebner cov tshuaj tiv thaiv, thiab lwm yam.
Muaj ntau daim ntawv thov ntawm quinolone: hauv kev tsim cov dyes, ua cov kuab tshuaj rau cov resins thiab terpenes, ua tus thawj coj los tsim 8-hydroxyquinoline, tsim cov quinolinic acid, tsim cov tshuaj tiv thaiv kab mob malarial derivatives, thiab lwm yam.
Isoquinoline yog dab tsi?
Isoquinoline yog ib qho isomer ntawm quinolone uas muaj cov tshuaj formula C
9H7N. Nws kuj tshwm sim raws li ib tug oily kua uas yog heev hygroscopic. Nws muaj zog thiab tsis kaj siab tsw. Cov kua tuaj yeem tig mus rau xim daj lossis xim av vim muaj cov impurities. Thaum crystallization, cov tshuaj no crystallizes li platelets. Cov platelets no muaj cov dej solubility tsawg, tab sis lawv yaj hauv cov kuab tshuaj organic xws li ether, ethanol, acetone, diethyl ether, carbon disulfide, thiab lwm yam. Nws kuj yog soluble hauv qee cov kua qaub.
Daim duab 02: Cov Qauv Tshuaj ntawm Isoquinoline
Ua ntej, isoquinoline tau muab rho tawm los ntawm cov thee tar, los ntawm kev faib ua feem. Isoquinoline yog qhov yooj yim dua li nws cov qauv isomer quinolone. Nws yog vim qhov sib txawv ntawm txoj haujlwm ntawm nitrogen atom hauv cov qauv no. Vim yog cov cuab yeej yooj yim no, peb tuaj yeem tau txais isoquinoline los ntawm cov thee tar los ntawm kev faib cov fractional distillation.
Muaj ntau cov ntawv thov tseem ceeb ntawm isoquinoline: ua cov tshuaj loog, ua cov tshuaj tiv thaiv kab mob, ua cov tshuaj tua kab mob, tshuaj tua kab mob, ua vasodilators, thiab lwm yam.
Qhov txawv ntawm Quinoline thiab Isoquinoline yog dab tsi?
Quinolone thiab isoquinoline yog isomers ntawm ib leeg. Cov qauv no tsim los ntawm kev sib xyaw ntawm lub nplhaib benzene thiab lub nplhaib pyridine. Qhov sib txawv tseem ceeb ntawm quinoline thiab isoquinoline yog nyob rau hauv quinolone, nitrogen atom nyob rau hauv thawj txoj hauj lwm ntawm lub nplhaib qauv, whereas nyob rau hauv isoquinoline, nitrogen atom nyob rau hauv lub thib ob txoj hauj lwm ntawm lub nplhaib qauv.
Muaj ntau daim ntawv thov ntawm quinoline, xws li hauv kev tsim cov dyes, ua cov kuab tshuaj rau cov resins thiab terpenes, ua tus thawj coj los tsim 8-hydroxyquinoline, tsim cov quinolinic acid, tsim cov tshuaj tiv thaiv kab mob malarial, thiab lwm yam. Cov ntawv thov ntawm isoquinoline suav nrog kev siv nws ua tshuaj loog, ua cov tshuaj tua kab mob, ua cov tshuaj tua kab mob, ua tshuaj tua kab mob, ua vasodilators, thiab lwm yam.
Hauv qab infographic qhia txog qhov sib txawv ntawm quinoline thiab isoquinoline.
Summary – Quinoline vs Isoquinoline
Quinolone thiab isoquinoline yog isomers ntawm ib leeg. Cov qauv no tsim los ntawm kev sib xyaw ntawm lub nplhaib benzene thiab lub nplhaib pyridine. Qhov sib txawv tseem ceeb ntawm quinoline thiab isoquinoline yog nyob rau hauv quinolone, nitrogen atom yog nyob rau hauv thawj txoj hauj lwm ntawm lub nplhaib qauv, whereas nyob rau hauv isoquinoline, lub nitrogen atom nyob rau hauv lub thib ob txoj hauj lwm ntawm lub nplhaib qauv.
