Qhov sib txawv tseem ceeb ntawm ANP thiab BNP yog qhov chaw zais cia tseem ceeb ntawm ANP yog lub atria thaum lub chaw zais cia tseem ceeb ntawm BNP yog lub ventricles.
Natriuretic peptides yog peptide cov tshuaj hormones secreted los ntawm lub plawv, hlwb thiab lwm yam kabmob. Atrial thiab ventricular distension thiab neurohumoral stimuli txhawb kev tso tawm ntawm cov tshuaj hormones natriuretic peptide los ntawm lub plawv. Atrial natriuretic peptide (ANP) thiab hlwb natriuretic peptide (BNP) yog ob hom natriuretic peptides. Lub luag haujlwm tseem ceeb ntawm natriuretic peptides yog txo qis ntshav siab los ntawm kev txo cov ntshav ntim thiab cov kab mob vascular tsis kam. Tsis tas li ntawd, lawv txo qis hauv nruab nrab venous siab, pulmonary capillary wedge siab, thiab cardiac output. Ob qho tib si ANP thiab BNP yog cov cim kev kuaj mob zoo rau cov neeg mob plawv. Lawv raug tso tawm nyob rau hauv teb rau mob plawv, sympathetic stimulation thiab angiotensin 2.
ANP yog dab tsi?
Lub atrial natriuretic peptide yog peptide hormone synthesized thiab khaws cia los ntawm atrial myocytes. Nws yog 28 amino acid peptide. ANPs yog synthesized nyob rau hauv teb rau atrial distension, angiotensin II stimulation, endothelin, thiab sympathetic stimulation. Yog li ntawd, theem ntawm ANP nce thaum lub sij hawm nce ntshav ntim vim yog lub plawv tsis ua hauj lwm. Atrial myocytes synthesize prepro-ANP thiab tom qab ntawd cleave rau pro-ANP thiab thaum kawg mus rau biologically active ANP.
Daim duab 01: ANP Structure
BNP yog dab tsi?
Brain natriuretic peptide lossis BNP yog lwm peptide-protein secreted los ntawm ventricles. Lub hlwb kuj tsim BNP hauv me me. BNP yog 32 amino acid peptide. Zoo ib yam li ANP synthesis, BNP kuj yog thawj synthesized li prepro-BNP. Tom qab ntawd nws yog cleaved rau pro-BNP thiab ces mus rau BNP.
Daim duab 02: BNP Structure
BNP tsim cov kev xaiv afferent arteriolar vasodilation, inhibits sodium reabsorption nyob rau hauv proximal convoluted tubule thiab inhibits renin thiab aldosterone tso tawm. Piv rau ANP, BNP muaj qhov tseem ceeb rau kev kuaj mob, kho, thiab kev cuam tshuam txog kev cuam tshuam.
Dab tsi yog qhov zoo sib xws ntawm ANP thiab BNP?
- ANP thiab BNP yog cov tshuaj lom neeg peptide cov tshuaj hormones.
- Lawv yog endogenously tsim los ntawm cardiomyocytes cardiac cov ntaub so ntswg raws li cardiac hormones.
- Plasma qib ntawm ANP thiab BNP nce siab hauv lub plawv tsis ua haujlwm ntev.
- Ob leeg khi rau natriuretic peptide receptor-A.
- Ventricles yog qhov chaw tseem ceeb rau BNP thiab ANP.
- Myocardial stretch yog qhov tseem ceeb hauv kev txhawb nqa kev tso tawm ntawm ANP thiab BNP.
- Ntxiv mus, ob qho tib si qhia txog kev cuam tshuam ntawm vasodilation, natriuresis, thiab inhibition ntawm renin-angiotensin-aldosterone (RAA) thiab lub paj hlwb sympathetic.
- ANP thiab BNP kuj inhibit aldosterone ntau lawm.
- Ob leeg yog cov cim tseem ceeb ntawm lub plawv thaum kho mob plawv.
- Dhau li ntawd, lawv cov synthesis pib ua prepro-ANP lossis BNP thiab tom qab ntawd zais rau hauv pro-ANP lossis BNP thiab thaum kawg mus rau ANP lossis BNP.
- BNP raug tso tawm los ntawm tib lub tswv yim uas tso tawm ANP, thiab nws muaj qhov ua haujlwm zoo sib xws.
Qhov txawv ntawm ANP thiab BNP yog dab tsi?
ANP thiab BNP yog cov tshuaj hormones plawv. ANP feem ntau yog synthesized nyob rau hauv thiab secreted los ntawm lub plawv atrium thaum BNP yog feem ntau secreted nyob rau hauv lub plawv ventricle. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ANP thiab BNP. Raws li txoj cai, ANP yog tsim los ntawm 28 amino acid peptide, thaum BNP yog tsim los ntawm 32 amino acid peptide. Ntxiv mus, ANP raug cais thiab txheeb xyuas thawj zaug, thiab tom qab ntawd BNP raug txheeb xyuas. Tsis tas li ntawd, qhov hnyav ntawm ANP yog 3078 Da thaum qhov hnyav ntawm BNP yog 3462 Da.
Cov lus hauv qab no qhia txog qhov sib txawv ntawm ANP thiab BNP.
Summary – ANP vs BNP
Muaj peb hom natriuretic peptides li ANP, BNP thiab CNP. ANP thiab BNP yog zais los ntawm lub plawv thiab ua raws li cov tshuaj hormones plawv. Qhov chaw ntawm kev zais ntawm ANP yog atria thaum lub chaw ntawm BNP secretion yog ventricles. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ANP thiab BNP. Ntxiv mus, ANP yog peptide muaj li ntawm 28 amino acid ib ntus thaum BNP yog peptide muaj li ntawm 32 amino acid sequence.
