Qhov Tseem Ceeb Qhov txawv - Agonist vs Antagonist Tshuaj
Opioids yog cov tshuaj uas suav nrog cov tshuaj tsis raug cai thiab cov tshuaj tau sau tseg. Opioids ua raws li kev kho mob tab sis muaj ntau yam kev mob tshwm sim tsis zoo yog tias noj ntau dhau. Cov txheej txheem ntawm opioids tuaj yeem piav qhia los ntawm ob lub tswv yim - agonistic mechanism thiab antagonistic mechanism. Yog li, cov tshuaj tuaj yeem muab faib ua cov tshuaj Agonist thiab cov tshuaj Antagonist. Agonist tshuaj yog cov tshuaj uas muaj peev xwm ua kom cov receptors nyob rau hauv lub hlwb thaum khi rau cov receptor uas ua rau tag nrho cov nyhuv ntawm opioids. Cov tshuaj antagonist khi rau cov receptors hauv lub hlwb thiab thaiv kev khi ntawm opioids rau cov receptors yog li inhibiting cov nyhuv ntawm opioid. Qhov sib txawv tseem ceeb ntawm agonists thiab antagonists yog lawv cov txheej txheem tiv thaiv. Agonists tsim kev nqis tes ua thaum antagonists inhibit qhov kev ua.
Tshuaj Agonist yog dab tsi?
Ib qho tshuaj agonist yog ib yam tshuaj uas ua rau lub cev ligand ntawm lub hlwb receptor tshwj xeeb. Yog li kev khi ntawm cov tshuaj agonist ua rau cov nyhuv lom neeg zoo ib yam li cov ligand ntuj. Tus agonist khi rau tib qhov chaw sib txuas raws li cov ligand ntuj. Yog li, thaum tsis muaj lub ntuj ligand, cov tshuaj agonist muaj peev xwm muab tag nrho lossis ib nrab cov lus teb. Piv txwv ntawm cov tshuaj agonist muaj xws li heroin, oxycodone, methadone, hydrocodone, morphine, thiab opium. Qee qhov uas nyiam tus heroin tau tshaj tawm tias tsis raug cai. Cov tshuaj no pab txo qhov mob. Cov koob tshuaj muaj zog tuaj yeem muaj ntau yam kev mob tshwm sim ntsig txog kev ua pa, lub cev tsis ua haujlwm, tsaug zog, thiab loog.
Daim duab 01: Mechanism ntawm Agonist thiab Antagonist tshuaj
Type of Agonist Drugs
Muaj ob hom tshuaj agonist;
- Direct binding agonist tshuaj
- Indirect binding agonist tshuaj
Direct binding agonist tshuaj los yog ua tiav agonists muaj peev xwm los khi ncaj qha mus rau qhov chaw tshwj xeeb khi ntawm cov receptor. Qhov chaw khi no yog qhov chaw uas lub ntuj ligand khi nyob rau hauv ib txwm muaj. Qhov no ua rau cov lus teb sai dua thaum nws txuas ncaj qha rau lub receptor thiab ua kom lub hlwb ua haujlwm. Piv txwv yog morphine thiab nicotine.
Indirect binding agonist tshuaj kuj tseem hu ua agonists ib nrab, yog cov tshuaj uas txhim kho txoj kev khi ntawm ntuj ligand rau cov receptor kom muaj txiaj ntsig. Cov tshuaj no muab cov lus teb qeeb. Ib qho piv txwv ntawm kev sib khi tsis ncaj agonist yog yeeb tshuaj.
Dab tsi yog tshuaj antagonist?
Cov tshuaj tiv thaiv kab mob yog cov tshuaj uas inhibit qhov cuam tshuam ntawm ntuj ligand. Lub ntuj ligand tuaj yeem yog cov tshuaj hormones, neurotransmitter lossis agonist.
Yam tshuaj tiv thaiv kab mob
Cov tshuaj tiv thaiv kab mob tuaj yeem yog peb hom tseem ceeb.
- sib tw antagonists
- Tsis yog - kev sib tw antagonists
- Irreversible antagonists
Daim duab 02: Mechanism of Antagonist tshuaj
Cov tshuaj sib tw antagonist yog cov tshuaj uas muaj peev xwm los khi rau ntawm qhov chaw khi qub thiab inhibit qhov kev khi ntawm ntuj ligand. Qhov no yog vim cov duab ntawm tus antagonist uas ua rau lub ntuj ligand. Ua kom cov ligand concentration tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev sib tw antagonist.
Cov tshuaj tiv thaiv tsis sib haum xeeb ua allosterically, qhov twg nws khi rau lwm qhov chaw uas tsis yog qhov chaw sib khi tiag. Kev sib khi ntawm cov tsis muaj kev sib tw antagonist yuav ua rau muaj kev hloov pauv hauv cov receptor uas yuav cuam tshuam kev khi ntawm ligand tseeb.
Irreversible agonist tshuaj khi rau cov receptor los ntawm covalent linkages. Qhov no yuav hloov mus tas li hloov kho cov receptor tiv thaiv kev khi ntawm ligand. Piv txwv ntawm cov tshuaj antagonist muaj xws li n altrexone thiab naloxone. Feem ntau cov tshuaj no yog siv los tiv thaiv cov teebmeem ntawm cov tshuaj phem xws li yeeb tshuaj yeeb thiab tshuaj yeeb dawb uas yog tshuaj agonist.
Dab tsi zoo sib xws ntawm Agonist thiab antagonist tshuaj?
- Ob leeg yog tshuaj lom neeg uas tuaj yeem khi rau receptors hauv lub hlwb.
- Ob leeg ua haujlwm hauv kev tawm tsam.
- Ob leeg tuaj yeem yog ob hom - tshuaj txhaum cai lossis tshuaj kho mob.
- Ob leeg yog tshwj xeeb rau cov receptors.
- Ob leeg raug hu ua tshuaj txo qhov mob.
- Ob leeg tuaj yeem ua rau muaj kev phom sij rau kev noj qab haus huv yog tias noj ntau dhau.
Qhov txawv ntawm Agonist thiab antagonist tshuaj yog dab tsi?
Agonist vs Antagonist tshuaj |
|
| Agonist tshuaj yog cov tshuaj uas muaj peev xwm ua kom cov receptors nyob rau hauv lub hlwb thaum khi rau cov receptor uas ua rau tag nrho cov nyhuv ntawm ligand. | Cov tshuaj tiv thaiv kab mob yog cov tshuaj uas khi rau cov receptors hauv lub hlwb thiab thaiv kev khi ntawm ligands rau cov receptors yog li inhibiting cov nyhuv ligand. |
| feeb | |
| tshuaj Agonist txhawb kev ua haujlwm. | Cov tshuaj tiv thaiv kab mob inhibit qhov kev ua. |
| Response | |
| Cov lus teb yog tshwm sim thaum tus agonist khi rau qhov chaw khi. | Cov lus teb raug tiv thaiv thaum tus antagonist khi rau ntawm qhov chaw khi. |
| Type | |
| Muaj ob hom tshuaj agonist; Direct binding agonist tshuaj thiab Indirect binding agonist tshuaj. | Muaj peb hom tshuaj tiv thaiv kab mob; Cov tshuaj sib tw antagonist, Tsis yog - cov tshuaj tiv thaiv kev sib tw, thiab cov tshuaj tiv thaiv tsis tuaj yeem. |
Summary – Agonist vs Antagonist Tshuaj
Agonist thiab antagonist tshuaj ua haujlwm hauv cov txheej txheem tiv thaiv. Cov tshuaj Agonist ua haujlwm hauv kev txhim kho cov txiaj ntsig ntawm lub ntuj ligand khi yog li nce- tswj cov nyhuv ntawm ligand. Hauv qhov sib piv, cov tshuaj Antagonist txo qis- tswj cov nyhuv ntawm ligand los ntawm kev khi rau cov receptor thiab thaiv cov receptor los ntawm kev khi rau nws cov receptor. Qhov no yog qhov sib txawv tseem ceeb ntawm cov tshuaj Agonistic thiab cov tshuaj Antagonistic. Ob qhov xwm txheej cuam tshuam rau kev txo qhov mob thiab yog li ua raws li cov tshuaj tua kab mob. Qee cov tshuaj xws li morphine tau raug sau tseg thiab raug cai siv los ntawm kev saib xyuas kev kho mob, qee qhov tsis raug cai siv (heroin).
Download the PDF Version of Agonist vs Antagonist Drugs
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Agonist thiab Antagonist Tshuaj
