Qhov Tseem Ceeb Qhov txawv - Glucocorticoids vs Corticosteroids
Cov corticosteroids yog cov chav kawm tshwj xeeb ntawm cov tshuaj hormones steroids uas tsim los ntawm adrenal cortex ntawm cov vertebrates. Niaj hnub no, hluavtaws analogues rau cov tshuaj hormones steroid no muaj nyob hauv khw. Muaj ob hom corticosteroids tseem ceeb xws li Glucocorticoids thiab Mineralcorticoids. Cov tshuaj hormones no muaj ntau yam kev ua haujlwm ntawm lub cev hauv tib neeg lub cev. Cov no suav nrog kev ntxhov siab, kev tiv thaiv kab mob, kev tswj cov txheej txheem o, carbohydrate metabolism, thiab protein metabolism, ntsuas cov ntshav electrolyte thiab tswj tus cwj pwm coj cwj pwm. Cortisol (C21H30O5), corticosterone (C21 H30O4) thiab cortisone (C21H28 O5) yog qee qhov tshwm sim ntawm glucocorticoids. Ntawm qhov tod tes, aldosterone (C21H28O5) yog ib qho tshwm sim ib txwm muaj mineralcorticoid. Txawm hais tias cortisone thiab aldosterone muaj tib cov tshuaj formula, lawv pom tias muaj qhov sib txawv. Yog li, qhov sib txawv tseem ceeb ntawm glucocorticoids thiab corticosteroids yog, glucocorticoids raug xa mus rau tsuas yog ib hom corticosteroids. Ntawm qhov tod tes, corticosteroids raug xa mus rau ob qho tib si glucocorticoids thiab mineralcorticoids ua ke.
Glucocorticoids yog dab tsi?
Glucocorticoids yog cov chav kawm ntawm cov tshuaj hormones steroids uas tau tsim los ntawm Zona Fasciculata ntawm adrenal cortex ntawm vertebrate. Cov tshuaj hormones no khi rau glucocorticoid receptor (GR-receptor) hauv vertebrate tsiaj hlwb. Qhov kev khi tshwj xeeb no (GR complex) ua kom muaj cov tshuaj tiv thaiv kab mob hauv lub cev. Thiab represses cov pro anti-inflammatory proteins nyob rau hauv lub cytosol los ntawm kev tiv thaiv translocation ntawm lwm yam transcription yam ntawm lub cytosol rau hauv lub nucleus.
Daim duab 01: Glucocorticoids tso tawm los ntawm Adrenals
Cov glucocorticoids txawv ntawm mineralocorticoids thiab kev sib deev steroids vim lawv qhov txawv receptors, lub hom phiaj hlwb, thiab kev ua haujlwm ntawm lub cev. Cortisol, cortisone, thiab corticosterone yog qee qhov tshwm sim ntawm glucocorticoids. Glucocorticoids nyob rau hauv kev tswj nruj ntawm ACTH ntawm adenohypophysis. Dexamethasone (siv rau cov kab mob ntawm daim tawv nqaij, mob hawb pob) thiab Hydrocortisone (siv nyob rau hauv adrenal insufficiency thiab congenital adrenal hyperplasia) yog cov ntshiab derivatives ntawm glucocorticoids.
Glucocorticoids tau qhia raws li cov haujlwm tshwj xeeb,
- Cov tshuaj hormones no tswj cov carbohydrates, rog thiab protein metabolism.
- YLawv txhawb nqa gluconeogenesis.
- Lawv txhawb kev tiv thaiv kab mob thiab tiv thaiv kev ua xua.
- Cov tshuaj hormones no koom nrog kho kev raug mob thiab tswj kev ntxhov siab.
- Lawv feem ntau npau taws mob.
Corticosteroids yog dab tsi?
Corticosteroids yog chav kawm ntawm cov tshuaj hormones steroids uas tau tsim los ntawm Zona Fasciculata thiab Zona glomerulosa ntawm adrenal cortex. Cov no suav nrog glucocorticoids thiab mineralocorticoids.
YGlucocorticoids
Glucocorticoids (Cortisol, cortisone, thiab corticosterone) txhawb thiab tswj cov carbohydrate, rog thiab protein metabolism. Lawv kuj muaj anti-inflammatory, antiproliferative, immunosuppressive thiab vasoconstrictive teebmeem. Anti-inflammatory nyhuv yog kho los ntawm inducing anti-inflammatory mediators.
Daim duab 02: Corticosteroids
Cov nyhuv tiv thaiv kab mob yog kho los ntawm inhibition ntawm DNA synthesis. Cov nyhuv immunosuppressive yog kho los ntawm suppressing qeeb hypersensitivity tshwm sim. Cov nyhuv vasoconstrictive yog kho los ntawm inhibiting inflammatory mediators xws li histidine.
Mineralocorticoids
Mineralocorticoids xws li aldosterone tswj thiab tswj cov electrolytes thiab dej sib npaug ntawm tib neeg lub cev los ntawm kev hloov pauv cov ion thauj hauv cov hlwb epithelial ntawm lub raum hlab ntawm lub raum.
Fludrocortisone (uas yog siv rau hauv adrenogenital syndrome thiab postural hypotension) yog ib qho derivative ntawm mineralocorticoids. Prednisone (uas yog siv rau hauv cov kab mob autoimmune thiab kev tsis haum tshuaj) muaj ob lub cim ntawm glucocorticoids thiab mineralocorticoids.
Dab tsi yog qhov zoo sib xws ntawm Glucocorticoid thiab Corticosteroid?
- Glucocorticoid thiab corticosteroid yog ob qho tshuaj steroids.
- Lawv yog tsim los ntawm adrenal cortex ntawm vertebrates.
- Glucocorticoid thiab corticosteroid yog ob qho tib si pab kho kev raug mob thiab tswj kev ntxhov siab.
- Glucocorticoid thiab corticosteroid yog ob qho tib si muaj "Sterane" nplhaib.
Qhov txawv ntawm Glucocorticoid thiab Corticosteroid yog dab tsi?
YGlucocorticoid vs Corticosteroid |
|
| Glucocorticoid tsuas yog ib hom corticosteroid uas tsim los ntawm Zona Fasciculata ntawm adrenal cortex ntawm vertebrate. | Corticosteroid xa mus rau ob qho tib si glucocorticoid thiab mineralocorticoid uas yog tsim los ntawm Zona Fasciculata thiab Zona glomerulosa ntawm adrenal cortex ntawm vertebrate. |
| Lub cev muaj nuj nqi | |
| Glucocorticoid tswj cov carbohydrates, rog, thiab cov metabolism hauv protein. | Corticosteroids tswj tag nrho cov txheej txheem metabolic hais txog cov carbohydrates, rog, protein thiab tswj cov electrolytes thiab dej sib npaug ntawm tib neeg lub cev. |
| Specific Function | |
| Glucocorticoids yog tshuaj tiv thaiv kab mob thiab tiv thaiv kev ua xua. | Corticosteroids yog tshuaj tiv thaiv kab mob, tiv thaiv kev loj hlob, tiv thaiv kab mob thiab vasoconstrictive. |
| Synthetic Derivatives | |
| Dexamethasone, Hydrocortisone yog cov khoom siv hluavtaws ntawm glucocorticoids. | Fludrocortisone yog ib qho khoom siv ntawm corticosteroids. |
Summary - Glucocorticoids vs Corticosteroids
Glucocorticoids tsuas yog ib hom corticosteroid xwb. Ntawm qhov tod tes, corticosteroids yog ob hom, 1. Glucocorticoid 2. Mineralocorticoid. Lawv txawv raws li kev ua haujlwm physiological. Glucocorticoids tswj cov carbohydrate, rog thiab protein metabolism. Corticosteroids sib nrug los ntawm kev tswj cov metabolism, lawv kuj tswj cov electrolytes thiab dej sib npaug hauv tib neeg lub cev. Ob leeg glucocorticoids thiab corticosteroids qhia cov lus teb los tiv thaiv. Qhov no tuaj yeem txheeb xyuas qhov txawv ntawm Glucocorticoids thiab Corticosteroids.
Download PDF Version ntawm Glucocorticoids vs Corticosteroid
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Glucocorticoids thiab Corticosteroids
