Qhov Tseem Ceeb - Kupffer Cells vs Hepatocytes
Lub siab yog ib qho tseem ceeb ntawm peb lub cev uas nyob rau sab xis ntawm lub plab thiab tiv thaiv los ntawm kab laug sab. Nws ua haujlwm ua ke nrog cov txiav thiab cov hnyuv kom zom, nqus thiab ua cov zaub mov uas peb noj. Lub luag haujlwm tseem ceeb ntawm daim siab yog qhov pom cov ntshav los ntawm lub plab zom mov, ua ntej xa mus rau lwm qhov ntawm lub cev. Tsis tas li ntawd, daim siab ua haujlwm hauv detoxification ntawm cov tshuaj, metabolism ntawm cov tshuaj, thiab synthesis ntawm cov proteins uas yog ib qho tseem ceeb rau cov ntshav coagulation thiab secretion ntawm cov kua tsib. Lub siab yog tsim los ntawm plaub hom cell loj xws li hepatocytes, kupffer cells, stellate (star-shaped) fat-storing cells thiab daim siab endothelial cells. Kupffer hlwb yog cov tshwj xeeb stellate macrophages uas ua haujlwm hauv lub siab kom tshem tawm cov kab mob uas nkag los ntawm plab mus rau cov ntshav. Hepatocytes yog feem ntau ntawm daim siab hlwb uas muaj li ntawm 80% ntawm cov hlwb hauv daim siab thiab lawv tso cov kua tsib. Qhov no yog qhov sib txawv tseem ceeb ntawm Kupffer hlwb thiab Hepatocytes.
Kupffer hlwb yog dab tsi?
Kupffer hlwb yog hom kab mob siab uas yog cov macrophages tshwj xeeb uas tau tawg nyob rau hauv sinusoidal endothelium ntawm daim siab. Lawv yog cov hnub qub zoo li lub hlwb. Lub luag haujlwm tseem ceeb ntawm kupffer hlwb yog tshem tawm cov kab mob uas tau nkag mus rau hauv cov ntshav portal ntawm lub plab. Kupffer hlwb muaj peev xwm phagocytize cov kab mob nkag los ntawm lub portal lossis hlab ntsha. Thiab kuj kupffer hlwb ua raws li antigen nthuav tawm cov hlwb hauv kev tiv thaiv kab mob. Cov hlwb no secrete chemokines thiab cytokines uas pab nyob rau hauv inflammatory tshuaj. Thiab tseem kupffer hlwb tau koom nrog hauv kev tshem tawm cov laus lossis cov laus erythrocytes los ntawm cov kab mob hauv lub cev thiab tso cov pab pawg heme rau rov siv dua. Kupffer hlwb ua raws li tus neeg kho mob tseem ceeb ntawm lub siab raug mob thiab kho lub siab.
Daim duab 01: Kupffer Cells
Kev ua haujlwm tsis zoo lossis kev hloov pauv hauv kupffer cell functions tuaj yeem ua rau lub siab raug mob thiab tshuaj lom neeg mob fibrosis uas tuaj yeem ua rau mob ntev hauv daim siab, suav nrog cov kab mob cawv thiab tsis muaj cawv. Kev kho mob ntawm kupffer hlwb tuaj yeem txhawb qhov kev daws teeb meem ntawm qhov mob thiab txhim kho qhov txhab kho ntawm daim siab kab mob.
Hepatocytes yog dab tsi?
Hepatocytes yog ib hom parenchymal hlwb uas nyob hauv daim siab. Lawv yog cov hlwb ntau tshaj plaws hauv daim siab uas suav txog 80% ntawm lub siab hlwb. Hepatocytes yog cov cell loj polyhedral nrog loj puag ncig hauv nruab nrab nuclei. Hepatocytes yog lub luag haujlwm rau ntau lub luag haujlwm ntawm lub siab. Lawv yog cov hlwb uas ua lub luag haujlwm tseem ceeb hauv cov metabolism, detoxification, thiab protein synthesis hauv peb lub cev. Thiab lawv kuj ua kom lub cev tiv thaiv kab mob hauv peb lub cev los ntawm kev sib txuas cov kab mob hauv lub cev tiv thaiv kab mob tiv thaiv kab mob. Hepatocytes tsim cov proteinase inhibitors nrog rau cov tshuaj antitrypsin, antichymotrypsin, α1-cysteine proteinase inhibitor (thiostain), thiab α2-macroglobulin los rhuav tshem cov proteases secreted los ntawm cov kab mob los yog cov kab mob tuag los yog tuag thiab txhawb kev ua kom lub cev tiv thaiv kab mob. Ntxiv mus, hepatocytes tsim ntau chemokines los qhib lub cev tiv thaiv kab mob.
Fibrinogen yog qhov tseem ceeb uas yog lub luag haujlwm rau cov ntshav coagulation. Fibrinogen feem ntau yog tsim los ntawm hepatocytes nyob rau hauv daim siab thiab kuj los ntawm cov ntshav albumin, prothrombin pawg clotting yam yog tsim los ntawm hepatocytes. Lwm lub luag haujlwm tseem ceeb ntawm hepatocytes yog detoxification ntawm exogenous thiab endogenous tebchaw. Tshuaj, tshuaj tua kab, cawv, ammonia, thiab steroids yog metabolized thiab detoxified los ntawm hepatocytes. Raws li qhov tshwm sim ntawm detoxification ntawm ammonia, ammonia hloov mus rau hauv urea rau excretion. Hepatocytes yog cov hlwb tseem ceeb uas tsim cov lipoproteins, ceruloplasmin, transferrin, ntxiv, thiab glycoproteins. Cov hlwb no koom nrog kev tswj hwm qib roj cholesterol hauv cov ntshav thiab tso cov kua tsib hauv peb lub cev. Qee cov tshuaj tiv thaiv kab mob kuj tau pom los ntawm hepatocytes hauv daim siab.
Daim duab 02: Hepatocytes
Kev ua haujlwm tsis zoo ntawm hepatocytes tuaj yeem ua rau lub siab tsis ua haujlwm thiab lub siab tsis ua haujlwm ntev. Lub siab yog lub cev zoo nkauj rau kev kho noob txij li lub hepatocytes muaj lub tshuab los qhia cov noob tshuaj uas pab txhawb kev tsim cov nplooj siab bioartificial los txhawb cov neeg mob lub siab tsis ua haujlwm.
Dab tsi zoo sib xws ntawm Kupffer Cells thiab Hepatocytes?
- Ob hom cell yog lub siab hlwb uas txhawb lub siab ua haujlwm.
- Ob lub hlwb ua haujlwm raws li cov hlwb txhawb peb lub cev tiv thaiv kab mob.
- Ob hom cell secrete chemokines.
- Ob lub hlwb koom nrog kev mob.
Qhov txawv ntawm Kupffer Cells thiab Hepatocytes yog dab tsi?
Kupffer Cells vs Hepatocytes |
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| Kupffer cells yog cov hlwb tshwj xeeb hauv macrophage hauv siab. | Hepatocytes yog cov hlwb parenchamal hauv siab. |
| Kupffer hlwb yog lub hnub qub zoo li (stellate). | Hepatocytes yog polygonal hauv cov duab. |
| Kupffer hlwb ua lub luag haujlwm tseem ceeb hauv kev tshem cov ntshav los ntawm kev noj cov kab mob kab mob. | Hepatocytes ua lub luag haujlwm tseem ceeb hauv kev tshem tawm cov co toxins, protein synthesis, kev tiv thaiv hauv lub cev thiab tso kua tsib. |
| Kupffer hlwb yog cov macrophages ntau tshaj plaws hauv peb lub cev. | Hepatocytes yog cov hlwb uas muaj parenchymal tshaj plaws hauv peb lub siab. |
Summary – Kupffer Cells vs Hepatocytes
Kupffer cells thiab hepatocytes yog ob hom kab mob siab uas cuam tshuam rau lub siab ua haujlwm. Hepatocytes yog hom cell ntau tshaj plaws hauv tib neeg lub siab thiab ua lub luag haujlwm tseem ceeb hauv ntau lub luag haujlwm ntawm lub siab xws li detoxification, protein synthesis, tshuaj thiab lipid metabolism, innate tiv thaiv kab mob thiab ntshav coagulation. Kupffer hlwb yog cov tshwj xeeb stellate macrophages hauv lub siab uas tshem cov ntshav los ntawm kev noj cov kab mob hauv plab. Qhov no yog qhov txawv ntawm kupffer hlwb thiab hepatocytes.
Download the PDF Version of Kupffer Cells vs Hepatocytes
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Kupffer Cells thiab Hepatocytes
