Qhov sib txawv tseem ceeb ntawm desmosomes thiab hemidesmosomes yog tias cov desmosomes ncaj qha tsim cov cell mus rau cell adhesions, thaum lub hemidesmosomes tsim adhesions ntawm hlwb thiab hauv qab daus membrane.
Cell to cell adhesions thiab cell junctions yog ib qho tseem ceeb kom muaj kev ncaj ncees ntawm cov ntaub so ntswg thiab ua kom lub cell rau cell signaling mechanisms. Muaj ntau hom cellular adhesions nyob rau hauv txhua hom ntawm eukaryotes siab dua. Nws yog ib qho tseem ceeb rau kev sib txawv ntawm cov cellular adhesions sib txawv kom nkag siab ntau ntxiv txog lawv cov txheej txheem lom neeg. Desmosomes thiab hemidesmosomes yog ob lub cell adhesion qauv sib tham hauv kab lus no.
Dab tsi yog Desmosomes?
Desmosomes, tseem hu ua macula adherens, yog cell rau cell adhesion qauv. Lawv faib yog random nyob rau hauv cov xwm. Txawm li cas los xij, lawv feem ntau yog teem ib ncig ntawm lub dav hlau sab nraud ntawm plasma membrane. Ntxiv mus, lawv muaj zog heev nyob rau hauv cov xwm. Yog li, desmosomes tuaj yeem tiv taus siab thiab kev ntxhov siab. Desmosomes muaj nyob rau hauv cov ntsiab lus sib txuas ntawm cov hlwb ntawm cov leeg plawv, cov ntaub so ntswg ntawm lub zais zis, txheej mucosal ntawm txoj hnyuv thiab cov epithelium.
Daim duab 01: Desmosome
Structurally, desmosomes yog complex filamentous qauv. Lawv nyob rau hauv lub cell adhesion protein tsev neeg: cadherin. Yog li ntawd, lawv muaj cov proteins xws li desmoglein thiab desmocollin hauv lawv cov qauv. Lawv yog cov qauv nruj heev, thiab cov proteins no pab tswj lawv cov rigidity. Qhov chaw sab nrauv ntawm desmosome tsim cov plaque uas muaj qhov ntom ntom ntom ntom. Lawv muaj desmoplakin hauv nws cov qauv.
Kev puas tsuaj rau desmosomes thiab kev hloov pauv hauv desmosomes ua rau muaj mob xws li arrhythmogenic cardiomyopathy thiab ntau yam kab mob autoimmune.
Hemidesmosomes yog dab tsi?
Hemidesmosomes yog hom kev sib txuas ntawm tes. Lawv yog cov me me thiab cov qauv zoo li stud, feem ntau pom nyob rau hauv cov epidermis ntawm daim tawv nqaij. Yog li, feem ntau keratinocytes muaj hemidesmosomes nyob nruab nrab ntawm lawv. Lawv muaj nyob rau hauv cov chaw uas cov epidermis tau txuas mus rau lub extracellular matrix. Yog li, hemidesmosome txuas rau ob qhov chaw ib txhij. Hemidesmosome faib kuj pom nyob rau hauv lub epithelial hlwb. Lawv tsim kev sib txuas ntawm cov hlwb epithelial thiab lamina lucida. Tsis tas li ntawd, hemidesmosomes kuj tau koom nrog hauv cov kev taw qhia ntawm tes.
Daim duab 02: Hemidesmosome
Muaj ob hom hemidesmosomes xws li hom I hemidesmosome thiab hom II hemidesmosome. Hom I hemidesmosomes muaj nyob rau hauv stratified thiab pseudostratified epithelium. Hom II hemidesmosomes muaj integrin thiab plectin hauv lawv. Ob leeg cov proteins no yog qhov tseem ceeb hauv kev tsim kev sib koom ua ke ntawm keratin. Tsis tas li ntawd, hemidesmosomes kuj muaj ntau receptors nyob rau hauv nws daim nyias nyias. Nws ua rau lub xov tooj ntawm tes taw qhia mechanisms.
Yog li, kev puas tsuaj hemidesmosome tuaj yeem ua rau poob ntawm cov tawv nqaij thiab ua rau cov leeg nqaij dystrophy. Tsis tas li ntawd, kev hloov pauv hauv cov lus qhia hemidesmosome kuj tuaj yeem ua rau epidermolysis bullosa.
Dab tsi yog qhov zoo sib xws ntawm Desmosomes thiab Hemidesmosomes?
- Desmosomes thiab hemidesmosomes yog cov membrane-bound organelles.
- Ntxiv mus, ob qho tib si yog puag ncig.
- Lawv muaj nyob rau hauv ntau lub cellular eukaryotes.
- ob leeg yog hom adhesion molecules.
- Functionally, lawv muab kev ncaj ncees rau ntau yam ntaub so ntswg thiab kabmob.
- Ob leeg yog ib qho tseem ceeb hauv kev ua raws li xov tooj ntawm tes taw qhia molecules rau kev taw qhia txoj hauv kev.
Qhov txawv ntawm Desmosomes thiab Hemidesmosomes yog dab tsi?
Qhov sib txawv tseem ceeb ntawm desmosomes thiab hemidesmosomes yog lub hauv paus ntawm lawv txoj haujlwm. Thaum desmosomes tsim cell rau cell adhesions, hemidesmosomes tsim adhesions ntawm hlwb thiab hauv qab daus daim nyias nyias. Yog li, cov proteins uas koom nrog hauv cov haujlwm ua haujlwm sib txawv ntawm desmosomes thiab hemidesmosomes. Desmoglein thiab desmocollin yog cov proteins koom nrog hauv desmosomes, thaum integrin thiab plectin yog cov proteins koom nrog hauv hemidesmosomes.
Cov hauv qab no nthuav tawm cov ntaub ntawv ntxiv txog qhov sib txawv ntawm desmosomes thiab hemidesmosomes.
Summary – Desmosomes vs Hemidesmosomes
Desmosomes thiab hemidesmosomes yog cov txheej txheem membrane uas ua raws li cov qauv adhesion. Desmosomes ua raws li cov cell rau cell adhesions thaum hemidesmosomes ua raws li adhesions uas tsim ntawm cov hlwb thiab hauv qab daus daim nyias nyias. Yog li, desmosomes yog cov hlwv nruj uas muaj nyob rau hauv cov nqaij mos ntawm lub plawv los yog lub plab hnyuv mucosa. Hauv kev sib piv, hemidesmosomes feem ntau pom muaj nyob hauv keratinocytes. Yog li, lawv pab txhawb cov adhesion ntawm keratinocytes rau hauv qab daus daim nyias nyias. Yog li, qhov no qhia txog qhov sib txawv ntawm desmosomes thiab hemidesmosomes.
