Qhov sib txawv tseem ceeb ntawm focal adhesion thiab hemidesmosomes yog qhov focal adhesion mediates lub adhesion ntawm cov hlwb thiab cov extracellular matrix thaum hemidesmosomes kho cov anchoring ntawm epidermal keratin filament cytoskeleton mus rau extracellular matrix.
Focal adhesion thiab hemidesmosomes yog ob hom kev sib cuam tshuam ntawm cov nplaum. Lawv tseem ceeb heev rau cov neeg kho tshuab kev ncaj ncees ntawm daim tawv nqaij. Focal adhesion thiab hemidesmosomes txuas ntxiv los ntawm lub cell rov qab mus rau lub cell pem hauv ntej. Ntxiv mus, lawv kuj ua lub luag haujlwm tseem ceeb hauv kev tsiv teb tsaws keratinocyte. Epidermal keratinocyte tsiv teb tsaws yog txuas rau qhov txhab kho qhov txhab ntawm rov epithelialization, uas pab kaw qhov txhab.
Focal Adhesion yog dab tsi?
Focal adhesion yog qhov chaw nplaum uas cov hlwb txuas mus rau cov matrix extracellular. Nws muaj pawg ntawm transmembrane integrin receptors tethered ntawm ib kawg mus rau extracellular matrix thiab lwm yam rau actin stress fibers. Focal adhesion yog lub luag haujlwm rau cell traction thiab extracellular matrix reorganization. Nws kho qhov kev sib txuas nruj ntawm cov hlwb thiab cov matrix extracellular, ua rau cov hlwb sib txuas lus nrog ib puag ncig sab nraud. Nws kuj tseem pab cell adhesion, migration, diffusion, sib txawv, thiab apoptosis.
Daim duab 01: Focal Adhesion
Focal adhesion feem ntau hu ua cell-matrix adhesion. Cov integrin receptors yog lub hauv paus ntawm focal adhesions. Integrins ncua lub plasma daim nyias nyias thiab txuas cov khoom sib txawv ntawm cov khoom sib txawv rau hauv lub cell. Cov integrins tsim cov heterodimers uas muaj alpha thiab beta subunits. Qhov no heterodimer khi rau lub extracellular matrix ntawm nws extracellular ligand-binding domain thiab anchors rau actin cytoskeleton ntawm nws cytosolic domain. Lwm cov proteins xws li talin, alpha-actinin, vinculin, paxillin, thiab focal adhesion kinase kuj tau raug xaiv los ua kom cov focal adhesion. Tsis tas li ntawd, qhov kev hloov pauv ntawm qhov focal adhesion uas tsis muaj suab nrov tuaj yeem ua rau mob qog noj ntshav thiab metastasis.
Hemidesmosomes yog dab tsi?
Hemidesmosomes kho kom haum rau kev thauj mus los ntawm cov kab mob epidermal keratin filament cytoskeleton mus rau extracellular matrix. Feem ntau, hemidesmosomes yog cov qauv me me zoo li pom nyob rau hauv keratinocytes ntawm cov epidermis ntawm daim tawv nqaij uas txuas mus rau lub extracellular matrix. Hemidesmosomes muaj ob hom: hom 1 thiab 2. Hom 1 hemidesmosomes muaj nyob rau hauv stratified thiab pseudo-stratified epithelium. Hom 1 hemidesmosomes muaj tsib lub ntsiab lus tseem ceeb: integrin α6β4, plectin 1a, tetraspanin protein CD151, BPAG1e, thiab BPAG2. Hom 2 hemidesmosomes muaj integrin α6β4 thiab plectin tsis muaj Bp antigens.
Daim duab 02: Hemidesmosomes
Cov kab mob caj ces lossis kis tau ua rau muaj kev cuam tshuam ntawm hemidesmosome Cheebtsam, ua rau cov tawv nqaij hlwv ntawm cov tawv nqaij sib txawv. Lawv raug hu ua epidermolysis bullosa (EB). Cov tsos mob ntawm tus kab mob no muaj xws li tawv nqaij tawv, hlwv kev loj hlob, thiab yaig los ntawm kev ntxhov siab ntawm lub cev me. Kev hloov pauv hauv 12 cov noob sib txawv uas cov cai rau qhov chaw ntawm hemidesmosomes tau coj mus rau epidermolysis bullosa. Raws li kev hloov pauv sib txawv, epidermolysis bullosa tau muab faib ua peb hom: EB simplex, dystrophic EB, thiab junctional EB.
Dab tsi zoo sib xws ntawm Focal Adhesion thiab Hemidesmosomes?
- Focal adhesion thiab hemidesmosomes yog ob hom kev sib cuam tshuam.
- Lawv tseem ceeb heev rau cov neeg kho tshuab kev ncaj ncees ntawm daim tawv nqaij
- Ob leeg ua lub luag haujlwm tseem ceeb hauv kev taw qhia ntawm tes.
- Lawv ua lub luag haujlwm tseem ceeb hauv kev tsiv teb tsaws keratinocyte.
- Ob leeg tseem ceeb heev rau daim tawv nqaij homeostasis.
- Integrins suav nrog hauv cov qauv ntawm ob qho tib si.
- Kev hloov pauv ntawm ob qho kev sib cuam tshuam tuaj yeem ua rau muaj kab mob sib txawv.
Qhov txawv ntawm Focal Adhesion thiab Hemidesmosomes yog dab tsi?
Focal adhesion mediates qhov adhesion ntawm cov hlwb thiab cov matrix extracellular thaum hemidesmosomes kho kom haum xeeb ntawm cov epidermal keratin filament cytoskeleton mus rau extracellular matrix. Qhov no yog qhov sib txawv tseem ceeb ntawm focal adhesion thiab hemidesmosomes. Tsis tas li ntawd, focal adhesion yog tsim los ntawm integrins heterodimers uas muaj alpha thiab beta subunits, talin, alpha-actinin, vinculin, paxillin, thiab focal adhesion kinase. Ntawm qhov tod tes, hemidesmosomes yog tsim los ntawm integrin α6β4, plectin 1a, tetraspanin protein CD151, BPAG1e thiab BPAG2.
Cov lus hauv qab no nthuav tawm qhov sib txawv ntawm focal adhesion thiab hemidesmosomes.
Summary – Focal Adhesion vs Hemidesmosomes
Focal adhesion thiab hemidesmosomes yog ob hom kev sib cuam tshuam nplaum uas tseem ceeb heev rau daim tawv nqaij homeostasis. Focal adhesion mediates lub adhesion ntawm cov hlwb thiab cov extracellular matrix, thaum hemidesmosomes mediate anchoring ntawm epidermal keratin filament cytoskeleton mus rau extracellular matrix. Qhov no yog qhov sib txawv tseem ceeb ntawm focal adhesion thiab hemidesmosomes
