Qhov sib txawv tseem ceeb ntawm kev tsis sib haum xeeb thiab genomic imprinting yog tias kev tsis sib haum xeeb yog hais txog ntau txheej txheej txheem xws li tau txais ob daim ntawv theej ntawm chromosome lossis ib feem ntawm chromosome thaum genomic imprinting yog hais txog cov txheej txheem uas ib daim ntawv luam ntawm tus noob yog inactivated.
Kev tsis sib haum xeeb tsis sib xws thiab genomic imprinting yog qhov tsis tshua muaj tshwm sim uas tshwm sim ntawm qib molecular. Cov txheej txheem no tswj cov noob qhia hauv eukaryotes. Ntxiv mus, cov txheej txheem tam sim no ua lub luag haujlwm tseem ceeb hauv kev kuaj kab mob thiab cov noob caj noob ces.
Kev tsis sib haum xeeb yog dab tsi?
Uniparental disomy yog qhov tshwm sim uas tus neeg tau txais ob daim ntawv theej ntawm chromosome. Nws kuj tseem tuaj yeem xa mus rau qhov tshwm sim ntawm kev txais ib feem ntawm chromosome los ntawm ib tus niam txiv. Uniparental Disomy yog ib qho tshwm sim tshwm sim thaum lub sij hawm kev loj hlob ntawm gametes. Cov txiaj ntsig ntawm kev tsis sib haum xeeb feem ntau yog nyob ntawm qhov qub txeeg qub teg thiab kev qhia ntawm cov noob tshwj xeeb. Yog li, qee zaus, kev tsis sib haum xeeb tsis zoo yuav cuam tshuam rau cov xeeb ntxwv. Yog li ntawd, nws tuaj yeem ua rau muaj kev nthuav tawm ntau dhau ntawm cov noob tshwj xeeb lossis tsis ua haujlwm ntawm cov noob.
Daim duab 01: Kev Tsis Pom Zoo Tsis Pom Zoo
Kev tsis sib haum xeeb tsis sib xws yuav ua rau chromosomal aberrations thiab qee yam kev tsis sib haum xeeb. Qee tus ntawm lawv suav nrog Prader-Willi syndrome thiab Angelman Syndrome. Prader-Willi syndrome yog txuam nrog kev rog rog thiab kev noj zaub mov tsis zoo, thaum Angelman syndrome ua rau muaj kev tsis taus ntawm cov neeg txawj ntse thiab kev hais lus tsis zoo. Txawm li cas los xij, uniparental disomy kuj tseem tuaj yeem ua rau qhov pib mob qog noj ntshav thiab nthuav tawm cov qog. Yog li, qhov no yog ib qho kev tsis zoo tshaj plaws ntawm kev tsis sib haum xeeb.
Genomic Imprinting yog dab tsi?
Genomic imprinting feem ntau tshwm sim thaum pib theem ntawm kev loj hlob ntawm lub cev. Txawm hais tias txhua tus neeg tau txais ob daim ntawv theej ntawm cov noob, feem ntau, tsuas yog ib daim ntawv theej yog nyob rau hauv nws daim ntawv nquag, thiab lwm yam yog nyob rau hauv daim ntawv tsis ua haujlwm. Tsis tas li ntawd, nws yuav tshwm sim nyob rau hauv qee cov noob, qhov twg ib daim ntawv qhib "rau", thiab lwm qhov yog "tawm".
Daim duab 02: Genome Imprinting
Genomic imprinting yog ib qho tseem ceeb los tswj cov noob caj noob ces hauv cov xeeb ntxwv. Kev yooj yim ntawm genomic imprinting tshwm sim los ntawm cov txheej txheem methylation. Methylation ntawm qee lub hauv paus lossis histone methylation yuav ua rau kev hloov pauv ntawm genome. Thiab, qhov no yuav ua rau genomic imprinting.
Meanwhile, tsis yog txhua tus noob muaj peev xwm ua rau muaj genomic imprinting. Txawm li cas los xij, qhov no tseem pab txhawm rau txheeb xyuas cov qauv kev sib raug zoo evolutionary. Ntxiv mus, cov imprinted noob feem ntau yog ua ke nyob rau hauv chromosome cheeb tsam.
Dab tsi yog qhov zoo sib xws ntawm Uniparental Disomy thiab Genomic Imprinting?
- Ob yam txheej txheem tshwm sim hauv eukaryotes.
- Ntxiv mus, ob qho tib si tshwm sim ntawm qib molecular.
- Ob txheej txheem cuam tshuam nrog caj ces thiab cov tswv yim qub txeeg qub teg.
- Cov txheej txheem no tuaj yeem kuaj tau nrog kev pab ntawm cov txheej txheem molecular xws li Polymerase saw cov tshuaj tiv thaiv, thiab lwm yam.
- Qhov tshwm sim tuaj yeem ua rau muaj kev cuam tshuam loj lossis nyob twj ywm yam tsis muaj kev cuam tshuam nyob ntawm txoj haujlwm gene.
Qhov txawv ntawm Uniparental Disomy thiab Genomic Imprinting yog dab tsi?
Kev tsis sib haum xeeb tsis sib haum xeeb thiab kev luam genomic yog ob lub ntsiab lus sib txawv. Uniparental disomy tsuas yog ib leeg niam txiv kab mob xwb, thaum genomic imprinting muaj ob leeg niam txiv. Uniparental disomy tshwm sim ntawm qhov chaw ntawm meiosis tsim gametes. Nyob rau hauv sib piv, genomic imprinting tshwm sim nyob rau hauv cov me nyuam tom qab fertilization txheej txheem. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm uniparental disomy thiab genomic imprinting.
Cov hauv qab no nthuav tawm cov ntaub ntawv ntau ntxiv txog qhov sib txawv ntawm kev tsis sib haum xeeb thiab genomic imprinting.
Summary – Uniparental Disomy vs Genomic Imprinting
Nyob rau hauv cov ntsiab lus sib txawv ntawm uniparental disomy thiab genomic imprinting; txoj kev tsis sib haum xeeb yog qhov tshwm sim uas ib leej niam leej txiv muab ob daim ntawv luam ntawm ib daim ntawv rau cov xeeb ntxwv. Yog li, qhov no yuav cuam tshuam ncaj qha rau cov qauv qub txeeg qub teg ntawm lub cev. Hauv qhov sib piv, genomic imprinting yog hais txog qhov tshwm sim ntawm inactivating ib daim qauv ntawm cov noob hauv cov xeeb ntxwv. Yog li ntawd, genomic imprinting tshwm sim tom qab fertilization txheej txheem. Txawm li cas los xij, ob qho xwm txheej no tseem ceeb hauv kev tswj hwm cov noob hauv eukaryotes.
