Qhov sib txawv tseem ceeb ntawm cov ntshav hlwb teeb meem thiab cov ntshav CSF barrier yog cov ntshav hlwb barrier yog lub barrier uas cais cov ntshav cov ntaub so ntswg thiab lub hlwb cov ntaub so ntswg thaum cov ntshav CSF barrier yog ib tug functional barrier uas cais cov ntshav cov ntaub so ntswg thiab lub cerebrospinal. dej.
Ntshav hlwb barrier thiab ntshav CSF barrier yog ob qho kev tiv thaiv hauv lub hlwb. Tsis tas li ntawd, lawv tseem ceeb hauv kev thauj cov molecules hla lub hlwb thiab cov hlab ntsha peripheral. Tsis tas li ntawd, ob qho tib si muaj kev sib tshuam nruj kom yooj yim rau kev hloov cov tshuaj tsis muaj tshuaj lom mus rau lub hlwb.
Ntshav Brain Barrier yog dab tsi?
Cov ntshav hlwb thaiv yog cov qauv uas cais cov hlwb thiab cov ntaub so ntswg. Nws muaj qhov tseem ceeb morphological. Muaj peb qhov tseem ceeb ntawm cov ntshav hlwb barrier. Lawv yog cov txheej ntawm endothelial hlwb, basal membrane, thiab astrocytes. Cov hlwb endothelial interconnect lub hlwb cov ntaub so ntswg thiab cov ntshav cov ntaub so ntswg los ntawm ib tug nruj hlws ris. Lub basal membrane pab kom cov astrocytes nyob rau hauv kev sib cuag. Cov astrocytes yog cov pedicles anneal rau basal membrane.
Cov hlab ntsha hlwb thaiv yog cov qauv xaiv permeable, tso cai rau cov khoom xaiv nkag mus rau hauv lub hlwb. Yog li ntawd, nws tsuas yog tso cai rau kev nkag mus ntawm cov khoom tsis muaj tshuaj lom, tsis muaj teeb meem rau hauv lub hlwb. Tsis tas li ntawd, cov hlab ntsha hauv cov hlab ntsha hla cov molecules xws li ions, ethanol thiab steroid cov tshuaj hormones los ntawm kev sib kis raws li lawv yog lipophilic. Muaj cov khoom thauj tam sim no nyob rau hauv cov ntshav hlwb teeb meem uas tso cai rau cov piam thaj thiab cov amino acids. Nws tshwm sim los ntawm kev thauj mus los. Tsis tas li ntawd, pinocytosis kuj tshwm sim nyob rau hauv cov ntshav hlwb thaiv kom dhau ib co macromolecules mus rau hauv lub hlwb cov ntaub so ntswg.
Daim duab 01: Kev Tiv Thaiv Kev Tiv Thaiv ntawm Lub Hlwb
Thaum thauj cov tshuaj hla cov hlab ntsha hauv lub hlwb, yuav tsum muaj cov txheej txheem ua ntej. Nws yuav tso cai rau kev nkag mus rau cov tshuaj tshwj xeeb rau hauv lub hlwb. Thaum tsis muaj precursors, tshuaj thiab tshuaj tua kab mob yuav tsis hla cov ntshav hlwb barrier.
Ntshav CSF Barrier yog dab tsi?
Ntshav CSF teeb meem, raws li lub npe qhia, cais cov kua cerebrospinal thiab cov ntshav. Cov kua dej cerebrospinal yog cov kua dej tiv thaiv ncig lub hlwb. Nws tiv thaiv lub hlwb los ntawm kev raug mob sab nraud thiab kev poob siab. Tsis tas li ntawd, CSF kuj muab cov kev ua haujlwm metabolic. Nws tswj kev nkag thiab tawm ntawm cov as-ham thiab cov khoom pov tseg rau lub hlwb. Zoo ib yam li cov hlab ntsha hlwb barrier, cov ntshav CSF barrier kuj muaj peb ntu: choroid epithelial hlwb, basal membrane thiab endothelium ntawm pia mater capillaries. Cov hlwb choroid epithelial tsim ib qho kev sib tshuam ntawm cov ntshav thiab CSF, thiab nws muaj microvilli hauv ob sab phlu.
Daim duab 02: Cerebrospinal Fluid
Lub luag haujlwm tseem ceeb ntawm cov ntshav CSF barrier yog xaiv kev nqus thiab nkag ntawm cov as-ham rau lub hlwb cawv (CSF). Nws permeability yog ntau dua li cov ntshav hlwb barrier. Cov as-ham ntws hla qhov concentration gradient mus rau CSF. Qhov tseem ceeb tshaj plaws, kev thauj mus los hauv cov ntshav CSF barrier yog bidirectional. Yog li, kev tshem tawm cov tshuaj lom metabolic pov tseg kuj tshwm sim hauv cov ntshav CSF teeb meem.
Dab tsi zoo sib xws ntawm Ntshav Brain Barrier thiab Ntshav CSF Barrier?
- Ntshav hlwb barrier thiab ntshav CSF barrier yog ob qho kev tiv thaiv ntawm lub hlwb.
- Ob lub qauv muaj peb ntu.
- Tseem, ob leeg muaj lub hauv paus membrane.
- Dhau li ntawd, ob qho tib si cov qauv yog xaiv permeable.
- Tsis tas li ntawd, cov kev sib tshuam nruj tam sim no nyob rau hauv ob qho kev thaiv.
Qhov txawv ntawm Ntshav Brain Barrier thiab Ntshav CSF Barrier yog dab tsi?
Cov ntshav hlwb barrier yog lub cev barrier thaum cov ntshav CSF barrier yog ib tug functional barrier. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cov ntshav hlwb barrier thiab ntshav CSF barrier. Tsis tas li ntawd, muaj qhov sib txawv ntawm cov ntshav hlwb barrier thiab ntshav CSF barrier nyob rau hauv cov nqe lus ntawm cov qauv. Lub endothelium nyob rau hauv cov ntshav hlwb barrier yog ua los ntawm cerebral capillary. Hauv qhov sib piv, cov ntshav CSF teeb meem yog ua los ntawm choroid plexus ntawm lub hlwb.
Ntxiv mus, qhov permeability ntawm cov ntshav hlwb teeb meem yog siab, thaum lub permeability ntawm cov ntshav CSF yog tsawg. Nws yog vim cov ntshav hlwb barrier muaj thaj tsam loj dua li cov ntshav CSF barrier. Yog li ntawd, peb tuaj yeem txiav txim siab qhov no kuj yog qhov sib txawv ntawm cov ntshav hlwb barrier thiab ntshav CSF barrier.
Summary – Blood Brain Barrier vs Blood CSF Barrier
Ntshav hlwb teeb meem thiab ntshav CSF teeb meem yog cov qauv tseem ceeb ntawm lub hlwb. Ntshav hlwb teeb meem yog ib qho kev sib cais ntawm lub cev ntawm cov ntshav thiab cov ntaub so ntswg ntawm lub hlwb. Nyob rau hauv sib piv, cov ntshav CSF barrier yog ib tug functional barrier uas nqa tawm lub nqus ntawm cov as-ham. Ob qho kev thaiv yog xaiv permeable thiab cia tsuas yog cov khoom tsis muaj tshuaj lom dhau los ntawm lawv. Txawm li cas los xij, cov ntshav hlwb barrier yog permeable ntau dua li cov ntshav CSF barrier. Nws kuj muaj qhov chaw siab dua. Yog li, qhov no qhia txog qhov sib txawv ntawm cov ntshav hlwb barrier thiab ntshav CSF barrier.
