Qhov sib txawv tseem ceeb ntawm coenzyme thiab cofactor yog cov coenzymes yog cov organic molecules, whereas cov cofactors tuaj yeem yog cov organic lossis inorganic molecules.
Enzymes yog qhov tseem ceeb ntawm cov roj ntsha macromolecules. Lawv yog cov lom catalysts, uas nce tus nqi ntawm cov tshuaj lom lom nyob rau hauv cov mob me heev. Ntxiv mus, enzymes yog cov proteins; Yog li, thaum lawv raug kub siab, ntsev concentrations, mechanical force, organic solvents thiab concentrated acid lossis base solutions, lawv zoo li denaturize. Qee zaum, enzymes xav tau kev txhawb nqa ntawm lwm cov molecule lossis ib qho ion kom muaj cov haujlwm tshwj xeeb. Coenzymes thiab cofactors yog cov molecules.
YCoenzyme yog dab tsi?
Coenzymes yog cov organic molecules me dua li cov enzyme (uas yog cov protein). Lawv feem ntau yog cov organic molecules, thiab ntau ntawm lawv muab los ntawm cov vitamins. Piv txwv li, niacin tsim cov coenzyme NAD + uas yog lub luag haujlwm rau cov tshuaj tiv thaiv oxidation.
Daim duab 01: Cov mis mos ntawm 3-methylglutaconyl-coenzyme A. Coenzymes yog Organic Molecules
Ntxiv mus, coenzyme A yog tsim los ntawm pantothenic acid, thiab lawv koom nrog cov tshuaj tiv thaiv raws li acetyl pab pawg neeg nqa khoom. Coenzymes yog ib hom cofactors. Txawm li cas los xij, coenzymes khi xoob nrog cov enzyme thaum muaj qee qhov cofactors, uas khi nruj rau cov enzyme.
Cofactor yog dab tsi?
Cofactors yog cov tshuaj pab hom (mob los yog ib qho ion), uas khi nrog cov enzymes txhawm rau coj tawm cov enzyme kev ua haujlwm lom neeg. Feem ntau ntawm cov enzymes xav tau cofactors los ua kom lawv cov haujlwm, thaum qee cov enzymes yuav tsis xav tau lawv. Ib qho enzyme uas tsis muaj cofactor yog apoenzyme. Thaum ib qho apoenzyme ua ke nrog nws cov cofactor, peb hu nws ua holoenzyme. Tsis tas li ntawd, qee cov enzymes tuaj yeem koom nrog ib cofactor thaum qee tus tuaj yeem koom nrog ntau cofactors.
Daim duab 02: Kev khi ntawm Coenzyme lossis Cofactor
Yog tsis muaj cov cofactors, cov haujlwm enzyme yuav ploj mus. Peb tuaj yeem faib cov molecules dav rau hauv ob pawg ua cov organic cofactors thiab inorganic cofactors. Cov inorganic feem ntau suav nrog cov hlau ions. Txawm li cas los xij, cov hlau ions no feem ntau xav tau nyob rau hauv kab. Piv txwv li, magnesium yog qhov tseem ceeb rau hexokinase, DNA polymerase thiab Glucose-6-phosphate enzymes thaum zinc yog ib qho tseem ceeb hlau ion rau cawv dehydrogenase, carbonic anhydrase thiab DNA polymerase muaj nuj nqi.
Qhov tseem ceeb
Lwm yam tshaj li magnesium thiab zinc, muaj lwm yam hlau ions xws li cupric, ferrous, ferric, manganese, nickel thiab lwm yam, uas koom nrog ntau hom enzymes. Cov hlau ions hauv enzymes tuaj yeem koom nrog cov txheej txheem catalytic hauv peb txoj hauv kev loj.
- Los ntawm khi rau lub substrate kom taw qhia nws kom zoo rau cov tshuaj tiv thaiv
- Thiab, los ntawm electrostatically stabilizing lossis tiv thaiv tus nqi tsis zoo
- Los ntawm kev txhawb oxidation, txo cov tshuaj tiv thaiv los ntawm kev hloov pauv ntawm cov hlau ions 'oxidation xeev
Ntxiv mus, cov organic cofactors feem ntau yog cov vitamins thiab lwm yam tsis yog vitamin organic molecules xws li ATP, glutathione, heme, CTP, coenzyme B, thiab lwm yam. Prosthetic pawg khi nruj nreem nrog cov enzyme thiab koom nrog cov enzyme catalysis cov tshuaj tiv thaiv. Thaum lub sij hawm cov tshuaj tiv thaiv, cov enzyme-prosthetic pawg complex tej zaum yuav raug hloov cov qauv, tab sis lawv tab tom los rau hauv lub xeev qub thaum cov tshuaj tiv thaiv lawm. FAD yog ib pawg prosthetic ntawm succinate dehydrogenase enzyme, uas txo rau FADH2 hauv cov txheej txheem ntawm hloov succinate rau fumarate.
Qhov txawv ntawm Coenzyme thiab Cofactor yog dab tsi?
Ib coenzyme yog cov organic uas tsis yog-protein compound uas khi nrog ib qho enzyme los catalyze cov tshuaj tiv thaiv thaum lub cofactor yog ib yam khoom (tshwj tsis yog cov substrate) uas nws muaj qhov tseem ceeb rau kev ua haujlwm ntawm enzyme. Yog li, Coenzymes yog ib hom cofactors. Qhov sib txawv tseem ceeb ntawm coenzyme thiab cofactor yog cov coenzymes yog cov organic molecules, whereas cov cofactors tuaj yeem yog cov organic lossis inorganic molecules.
Ntxiv mus, cov coenzymes tau khi nrog cov enzymes, tab sis muaj qee qhov cofactors, uas tau khi nruj rau cov enzyme. Tsis tas li ntawd, coenzyme tuaj yeem raug tshem tawm los ntawm cov enzyme yooj yim thaum cofactor tsuas yog tshem tawm los ntawm denaturing enzyme. Yog li, qhov no yog lwm qhov sib txawv ntawm coenzyme thiab cofactor.
Cov hauv qab no qhia txog qhov sib txawv ntawm coenzyme thiab cofactor hauv daim ntawv tabular.
Summary – Coenzyme vs Cofactor
Coenzymes yog ib hom cofactors. Txawm li cas los xij, muaj qhov sib txawv ntawm lawv. Qhov sib txawv tseem ceeb ntawm coenzyme thiab cofactor yog cov coenzymes yog cov organic molecules, whereas cov cofactors tuaj yeem yog cov organic lossis inorganic molecules.
