Qhov sib txawv tseem ceeb ntawm kev colonization thiab kev kis kab mob yog kev colonization yog txheej txheem tsim cov microbe hauv cov ntaub so ntswg hauv lub cev thaum kis kab mob yog cov txheej txheem ntawm kev nkag mus rau hauv lub cev cov ntaub so ntswg los ntawm microbe los ua cov tsos mob ntawm tus kab mob.
Cov kab mob ntawm cov kab mob microbes yog ua tiav biochemical thiab txheej txheem txheej txheem uas tau txhais los ntawm kev ua tiav cov txheej txheem uas cov kab mob ua rau tus kab mob. Piv txwv li, cov kab mob pathogenic tuaj yeem cuam tshuam nrog cov khoom sib txawv ntawm cov kab mob ntawm tes xws li tshuaj ntsiav, fimbriae, lipopolysaccharides (LPS) thiab lwm yam ntawm cov phab ntsa ntawm tes. Peb kuj tuaj yeem koom nrog nws nrog kev tso tawm ntawm cov tshuaj uas ua rau cov ntaub so ntswg puas tsuaj lossis tiv thaiv cov kab mob los ntawm kev tiv thaiv tus tswv. Colonization thiab kab mob yog ob nqe lus hauv microbial pathogenicity. Thawj theem ntawm microbial pathogenicity yog colonization. Nws yog lub npe hu ua qhov tseeb tsim ntawm cov kab mob hauv cov ntaub so ntswg. Ntawm qhov tsis sib xws, kev kis kab mob yog kev cuam tshuam ntawm cov ntaub so ntswg ntawm lub cev los ntawm cov kab mob ua rau tus kab mob.
Colonization yog dab tsi?
Nov yog thawj kauj ruam ntawm microbial thiab kab mob colonization. Nws yog qhov tsim nyog ntawm cov kab mob ntawm txoj cai portal ntawm kev nkag ntawm tus tswv tsev. Cov kab mob feem ntau yog colonized nrog cov ntaub so ntswg ntawm tus tswv tsev uas muaj kev sib cuag nrog ib puag ncig sab nraud. Lub portal ntawm kev nkag rau hauv tib neeg yog urogenital ib ntsuj av, digestive ib ntsuj av, ua pa ib ntsuj av tau, daim tawv nqaij, thiab conjunctiva. Cov kab mob ib txwm muaj uas colonize cov cheeb tsam no muaj cov ntaub so ntswg adherence mechanisms. Cov kev ua raws li cov txheej txheem no muaj peev xwm kov yeej thiab tiv taus lub siab tas li uas tau hais los ntawm tus tswv tsev tiv thaiv. Nws tuaj yeem piav qhia yooj yim los ntawm kev ua raws li cov txheej txheem uas tau pom los ntawm cov kab mob thaum txuas mus rau qhov chaw mucosal hauv tib neeg.
Daim duab 01: Colonization of a Pathogen
Cov kab mob txuas mus rau qhov chaw eukaryotic xav tau ob yam, xws li receptor thiab ligand. Cov receptors feem ntau yog cov carbohydrates los yog peptides residues nyob rau ntawm eukaryotic cell nto. Cov kab mob ligands hu ua adhesions. Nws feem ntau yog ib qho macromolecular tivthaiv ntawm cov kab mob ntawm tes. Cov adhesions yog cuam tshuam nrog cov tswv tsev cell receptors. Cov adhesions thiab tus tswv tsev cell receptors feem ntau cuam tshuam rau hauv ib qho kev sib txuas ntxiv. Qhov tshwj xeeb no yog piv rau hom kev sib raug zoo ntawm enzyme thiab substrate lossis antibody thiab antigen. Ntxiv mus, qee cov ligands hauv cov kab mob tau piav qhia xws li, Hom 1 fimbriae, Hom 4 pili, S-txheej, Glycocalyx, capsule, lipopolysaccharide (LPS), teichoic acid thiab lipoteichoic acid (LTA).
Kab mob yog dab tsi?
Kev kis kab mob yog kev cuam tshuam ntawm cov ntaub so ntswg hauv lub cev los ntawm cov kab mob sib kis xws li cov kab mob, kab mob, lawv cov kev sib npaug thiab cov lus teb los ntawm cov tswv rau cov kab mob tshwj xeeb lossis cov co toxins. Cov kab mob sib kis thiab kis kab mob yog lwm lub npe rau cov kab mob sib kis. Cov tswv tsev zoo li tib neeg tuaj yeem kov yeej kev kis kab mob los ntawm kev siv lawv lub cev tsis muaj zog thiab hloov kho lub cev. Lub cev tiv thaiv kab mob hauv lub cev muaj cov hlwb xws li dendritic cells, neutrophils, mast cells thiab macrophages uas tuaj yeem tiv thaiv kab mob. Ntxiv mus, receptors zoo li TLR'S (Xov-zoo li receptors) nyob rau hauv lub cev tiv thaiv kab mob yooj yim paub cov kab mob. Cov tshuaj tua kab mob zoo li lysosomes enzymes tseem ceeb heev hauv lub cev tiv thaiv kab mob.
Nyob rau hauv cov ntaub ntawv ntawm lub cev tiv thaiv kab mob, cov antigen nthuav tawm cov hlwb (APS), B hlwb thiab T lymphocytes yog sib sau ua ke inducing antigen-antibody cov tshuaj tiv thaiv kom tshem tawm cov kab mob ntawm tib neeg lub cev tag nrho. Txawm li cas los xij, tus kab mob muaj ntau yam txheej txheem txhawm rau txhawm rau kov yeej lub cev tsis muaj zog thiab hloov pauv ntawm tib neeg. Tsis tas li ntawd, cov kab mob muaj evading mechanisms xws li tiv thaiv los ntawm kev txuas rau tib neeg macrophages thiab lysosomes. Tsis tas li ntawd, cov kab mob tsim cov co toxins xws li endotoxins, enterotoxins, Shiga toxins, cytotoxins, cov co toxins uas muaj cua sov, thiab cov co toxins uas kub-labile. Qee cov kab mob uas paub zoo xws li Salmonella, E-coli tsim cov co toxins hauv cov txheej txheem kis tau zoo. Tsis tas li ntawd, kev kis tus kab mob ua tiav tsuas yog nce los ntawm kev kov yeej cov txheej txheem tiv thaiv kab mob molecular ntawm cov tswv.
Dab tsi yog qhov Zoo sib xws ntawm Colonization thiab Kab Mob?
- Colonization thiab kab mob yog cov kauj ruam tseem ceeb ntawm microbial pathogenicity.
- Lawv sib koom ua tus kab mob.
- Ntxiv mus, ob kauj ruam no tseem ceeb heev rau qhov tshwm sim ntawm tus kab mob lossis cov tsos mob.
- Ob leeg yog qhov tseem ceeb sib npaug rau kev sib kis kab mob.
Qhov txawv ntawm Colonization thiab Kab Mob yog dab tsi?
Colonization yog txheej txheem ntawm kev tsim cov microbe hauv lub cev cov ntaub so ntswg. Nyob rau hauv sib piv, tus kab mob yog invasion ntawm lub cev nqaij daim tawv los ntawm ib tug pathogen, lawv multiplication thiab, cov lus teb los ntawm cov tswv rau tej yam kis kab mob los yog co toxins ntawm cov kab mob. Adhesins zoo li pili, fimbriae, thiab LPS yog qhov tseem ceeb heev rau kev colonization thaum kis kab mob tsis xav tau adhesions. Ntxiv mus, Cov cell receptors tseem ceeb hauv kev txuas mus rau cov kab mob kom ua tiav txoj kev colonization; Txawm li cas los xij, cov cell receptors tsis tseem ceeb rau kev kis kab mob.
Lwm qhov sib txawv ntawm kev colonization thiab kab mob yog lawv cov tshuaj lom ntau lawm. Colonization tsis tsim cov co toxins thaum kis kab mob. Tsis tas li ntawd, tus qub tsis ua rau tus kab mob lossis cov tsos mob tshwm sim thaum yav tas los. Lwm qhov sib txawv ntawm colonization thiab kab mob yog mob o. Colonization tsis ua rau mob hnyav lossis ua mob rau tus tswv thaum kis kab mob ua rau mob hnyav thiab ua mob rau cov ntaub so ntswg.
Summary – Colonization vs Infection
Cov kab mob tshwm sim hauv cov kab mob muaj feem cuam tshuam nrog cov khoom sib txawv ntawm cov kab mob ntawm tes xws li tshuaj ntsiav, fimbriae, lipopolysaccharides (LPS), pili thiab lwm yam ntawm cov phab ntsa ntawm tes xws li teichoic acid, glycocalyx, thiab lwm yam. mus rau lub active secretion ntawm cov tshuaj uas ua puas lub tsev ntaub so ntswg los yog tiv thaiv cov kab mob los ntawm tus tswv tsev tiv thaiv. Colonization thiab kab mob yog ob kauj ruam tseem ceeb hauv microbial pathogenicity. Thawj theem ntawm microbial pathogenicity yog colonization. Nws yog qhov tsim nyog ntawm cov kab mob hauv cov ntaub so ntswg los yog txoj cai portal ntawm kev nkag ntawm tus tswv tsev. Ntawm qhov tsis sib xws, kev kis kab mob yog kev cuam tshuam ntawm cov ntaub so ntswg ntawm lub cev los ntawm cov kab mob los ua tus kab mob. Qhov no yog qhov txawv ntawm colonization thiab kab mob.
Download PDF Version of Colonization vs Infection
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Colonization thiab Kab Mob
